A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Ching Hua Tsai; Yi Hsuan Tang; Hui Ting Chen; Yi Wen Yao; Tun Cheng Chien; Chai Lin Kao

doi:10.1039/c8cc00914g

A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Ching Hua Tsai, Yi Hsuan Tang, Hui Ting Chen, Yi Wen Yao, Tun Cheng Chien^*, Chai Lin Kao

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

Original language	English
Pages (from-to)	4577-4580
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	36
DOIs	https://doi.org/10.1039/c8cc00914g
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.",

author = "Tsai, {Ching Hua} and Tang, {Yi Hsuan} and Chen, {Hui Ting} and Yao, {Yi Wen} and Chien, {Tun Cheng} and Kao, {Chai Lin}",

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AU - Tsai, Ching Hua

AU - Tang, Yi Hsuan

AU - Chen, Hui Ting

AU - Yao, Yi Wen

AU - Chien, Tun Cheng

AU - Kao, Chai Lin

N1 - Publisher Copyright: © The Royal Society of Chemistry 2018.

PY - 2018

Y1 - 2018

N2 - Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

AB - Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

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A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Abstract

ASJC Scopus subject areas

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