A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Ching Hua Tsai, Yi Hsuan Tang, Hui Ting Chen, Yi Wen Yao, Tun Cheng Chien, Chai Lin Kao

Research output: Contribution to journalArticle

7 Citations (Scopus)


Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

Original languageEnglish
Pages (from-to)4577-4580
Number of pages4
JournalChemical Communications
Issue number36
Publication statusPublished - 2018 Jan 1


ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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