A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres

Yu Ling Ni, Chang Hung Hsieh, Seung Hun Kim, Jing Ping Wang, Chun Li Su, Ching Fa Yao, Kang Fang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To fight cancer at its roots by targeting cancer stem cells is a promising approach for therapy. Previously, an indolylquinoline derivative, 3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline (EMMQ), was reported effectively inhibiting the growth of lung cancer cells through impairment of cellular mitochondria functions. To address more on drug efficiency, the study further exploited if EMMQ can impede the propagation of tumorspheres stemmed from non-small cell lung cancer cells. EMMQ inhibited proliferation of spheroids in culture. In animal models, administration of the drug attenuated the spheroid tumorigenicity. The activated apoptosis alleviated growth of xenograft tumors in immune-deficient mice as established by the enriched tumorspheres. More evidence suggested that the reduced stemness of the spheroid tumors is attributed to apoptotic death. The findings supported that EMMQ is an eligible approach to eradicate the minor but tumorigenic lung cancer tumorspheres.

Original languageEnglish
Pages (from-to)1235-1245
Number of pages11
JournalApoptosis
Volume22
Issue number10
DOIs
Publication statusPublished - 2017 Oct 1

Fingerprint

Lung Neoplasms
Cells
Tumors
Growth
Neoplasms
Mitochondria
Neoplastic Stem Cells
Stem cells
Cell culture
Heterografts
Non-Small Cell Lung Carcinoma
Pharmaceutical Preparations
Animals
Animal Models
Apoptosis
Derivatives
Therapeutics
2-methylquinoline

Keywords

  • Apoptosis
  • Cancer stem cells
  • Indolylquinoline
  • Non-small cell lung cancer cells
  • Xenograft tumors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

Cite this

A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres. / Ni, Yu Ling; Hsieh, Chang Hung; Kim, Seung Hun; Wang, Jing Ping; Su, Chun Li; Yao, Ching Fa; Fang, Kang.

In: Apoptosis, Vol. 22, No. 10, 01.10.2017, p. 1235-1245.

Research output: Contribution to journalArticle

Ni, Yu Ling ; Hsieh, Chang Hung ; Kim, Seung Hun ; Wang, Jing Ping ; Su, Chun Li ; Yao, Ching Fa ; Fang, Kang. / A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres. In: Apoptosis. 2017 ; Vol. 22, No. 10. pp. 1235-1245.
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