A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks

Chien Ping Fu; Stephen Lirio; Wan Ling Liu; Chia Her Lin; Hsi Ya Huang

doi:10.1016/j.aca.2015.07.029

A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks

Chien Ping Fu, Stephen Lirio, Wan Ling Liu, Chia Her Lin, Hsi Ya Huang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	Analytica Chimica Acta
Volume	888
DOIs	https://doi.org/10.1016/j.aca.2015.07.029
Publication status	Published - 2015
Externally published	Yes

Keywords

Biomolecules
Carbohydrates
Metal-organic frameworks
Peptides
Surface-assisted laser desorption eionization mass spectrometry

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy

Access to Document

10.1016/j.aca.2015.07.029

Cite this

@article{4c42a3739c1d49cf8197e6d1e794ff18,

title = "A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks",

abstract = "A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.",

keywords = "Biomolecules, Carbohydrates, Metal-organic frameworks, Peptides, Surface-assisted laser desorption eionization mass spectrometry",

author = "Fu, {Chien Ping} and Stephen Lirio and Liu, {Wan Ling} and Lin, {Chia Her} and Huang, {Hsi Ya}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

doi = "10.1016/j.aca.2015.07.029",

language = "English",

volume = "888",

pages = "103--109",

journal = "Analytica Chimica Acta",

issn = "0003-2670",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks

AU - Fu, Chien Ping

AU - Lirio, Stephen

AU - Liu, Wan Ling

AU - Lin, Chia Her

AU - Huang, Hsi Ya

PY - 2015

Y1 - 2015

N2 - A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

AB - A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

KW - Biomolecules

KW - Carbohydrates

KW - Metal-organic frameworks

KW - Peptides

KW - Surface-assisted laser desorption eionization mass spectrometry

UR - http://www.scopus.com/inward/record.url?scp=84951152030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951152030&partnerID=8YFLogxK

U2 - 10.1016/j.aca.2015.07.029

DO - 10.1016/j.aca.2015.07.029

M3 - Article

C2 - 26320964

AN - SCOPUS:84951152030

SN - 0003-2670

VL - 888

SP - 103

EP - 109

JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

ER -

A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this