A novel type of matrix for surface-assisted laser desorptioneionization mass spectrometric detection of biomolecules using metal-organic frameworks

Chien Ping Fu, Stephen Lirio, Wan Ling Liu, Chia Her Lin, Hsi Ya Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalAnalytica Chimica Acta
Volume888
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Biomolecules
  • Carbohydrates
  • Metal-organic frameworks
  • Peptides
  • Surface-assisted laser desorption eionization mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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