A novel synthetic approach to medium ring lactones via dienetricarbonyliron complexes

Ming Liang Lai, Shun Chi Chang, Chung Chen Hwu, Ming Chang P. Yeh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Reaction of lithium diisopropylamine (LDA) with (η4-1,3-buadiene)Fe(CO)3 complexes bearing carboester functionalized side chains at C-5 gives eight- to ten-membered lactones as the major products after electrophilic quenching. However, treatments of the complexes with LDA, under an atmosphere of carbon monoxide, furnish bridged bicyclo[5.2.1]decane and bicyclo[6.2.1]undecane lactone skeletons as the major products.

Original languageEnglish
Pages (from-to)6149-6152
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number34
DOIs
Publication statusPublished - 1996 Aug 19

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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