A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al3+/PPi and its potential use in biodetection and bioimaging applications

Moorthy Mathivanan; Balamurugan Tharmalingam; Thangaraj Devaraj; Abinayaselvi Murugan; Chia Her Lin; Mathivanan Jothi; Balasubramanian Murugesapandian

doi:10.1039/d0nj05718e

A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al³⁺/PPi and its potential use in biodetection and bioimaging applications

Moorthy Mathivanan, Balamurugan Tharmalingam, Thangaraj Devaraj, Abinayaselvi Murugan, Chia Her Lin, Mathivanan Jothi^*, Balasubramanian Murugesapandian

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Herein, we have developed a new7-diethylamino-4-hydroxycoumarin appended acylhydrazone (L) probe using a simple condensation reaction. The structure of the probeLwas characterizedviasingle crystal X-ray analysis. This probeLcan selectively detect Al³⁺metal ionsviaa colorimetric as well as fluorescence turn-on strategy over other metal ions. Besides, the probe can also detect the aluminium ions in pharmaceutical tablets. The resultingL-Al³⁺ensemble has been exploited as a turn-off fluorescence sensor for the detection of pyrophosphate (PPi) anion through metal displacement or by using a decomplexation approach. Based on reversible “off-on-off” emission characteristics, the probe was applied for the construction of molecular logic gates and the development of a paper strip kit for on-site detection applications. In addition, this ensemble can also be utilized to detect PPi released during DNA synthesis and biological extracts, and in live cells.

Original language	English
Pages (from-to)	6067-6079
Number of pages	13
Journal	New Journal of Chemistry
Volume	45
Issue number	13
DOIs	https://doi.org/10.1039/d0nj05718e
Publication status	Published - 2021 Apr 7

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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10.1039/d0nj05718e

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Mathivanan, M., Tharmalingam, B., Devaraj, T., Murugan, A., Lin, C. H., Jothi, M., & Murugesapandian, B. (2021). A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al³⁺/PPi and its potential use in biodetection and bioimaging applications. New Journal of Chemistry, 45(13), 6067-6079. https://doi.org/10.1039/d0nj05718e

A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al³⁺/PPi and its potential use in biodetection and bioimaging applications. / Mathivanan, Moorthy; Tharmalingam, Balamurugan; Devaraj, Thangaraj et al.
In: New Journal of Chemistry, Vol. 45, No. 13, 07.04.2021, p. 6067-6079.

Research output: Contribution to journal › Article › peer-review

Mathivanan, M, Tharmalingam, B, Devaraj, T, Murugan, A, Lin, CH, Jothi, M & Murugesapandian, B 2021, 'A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al³⁺/PPi and its potential use in biodetection and bioimaging applications', New Journal of Chemistry, vol. 45, no. 13, pp. 6067-6079. https://doi.org/10.1039/d0nj05718e

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abstract = "Herein, we have developed a new7-diethylamino-4-hydroxycoumarin appended acylhydrazone (L) probe using a simple condensation reaction. The structure of the probeLwas characterizedviasingle crystal X-ray analysis. This probeLcan selectively detect Al3+metal ionsviaa colorimetric as well as fluorescence turn-on strategy over other metal ions. Besides, the probe can also detect the aluminium ions in pharmaceutical tablets. The resultingL-Al3+ensemble has been exploited as a turn-off fluorescence sensor for the detection of pyrophosphate (PPi) anion through metal displacement or by using a decomplexation approach. Based on reversible “off-on-off” emission characteristics, the probe was applied for the construction of molecular logic gates and the development of a paper strip kit for on-site detection applications. In addition, this ensemble can also be utilized to detect PPi released during DNA synthesis and biological extracts, and in live cells.",

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A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al³⁺/PPi and its potential use in biodetection and bioimaging applications

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CCDC 2016035: Experimental Crystal Structure Determination

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A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al3+/PPi and its potential use in biodetection and bioimaging applications

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CCDC 2016035: Experimental Crystal Structure Determination

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A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al³⁺/PPi and its potential use in biodetection and bioimaging applications