Herein, we have developed a new7-diethylamino-4-hydroxycoumarin appended acylhydrazone (L) probe using a simple condensation reaction. The structure of the probeLwas characterizedviasingle crystal X-ray analysis. This probeLcan selectively detect Al3+metal ionsviaa colorimetric as well as fluorescence turn-on strategy over other metal ions. Besides, the probe can also detect the aluminium ions in pharmaceutical tablets. The resultingL-Al3+ensemble has been exploited as a turn-off fluorescence sensor for the detection of pyrophosphate (PPi) anion through metal displacement or by using a decomplexation approach. Based on reversible “off-on-off” emission characteristics, the probe was applied for the construction of molecular logic gates and the development of a paper strip kit for on-site detection applications. In addition, this ensemble can also be utilized to detect PPi released during DNA synthesis and biological extracts, and in live cells.
ASJC Scopus subject areas
- Materials Chemistry
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Mathivanan, M. (Contributor), Tharmalingam, B. (Contributor), Devaraj, T. (Contributor), Murugan, A. (Contributor), Lin, C. H. (Contributor), Jothi, M. (Contributor), Murugesapandian, B. (Contributor) & Jothi, M. (Contributor), The Cambridge Structural Database, 2021