A new7-diethylamino-4-hydroxycoumarin based reversible colorimetric/fluorometric probe for sequential detection of Al3+/PPi and its potential use in biodetection and bioimaging applications

Moorthy Mathivanan, Balamurugan Tharmalingam, Thangaraj Devaraj, Abinayaselvi Murugan, Chia Her Lin, Mathivanan Jothi*, Balasubramanian Murugesapandian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Herein, we have developed a new7-diethylamino-4-hydroxycoumarin appended acylhydrazone (L) probe using a simple condensation reaction. The structure of the probeLwas characterizedviasingle crystal X-ray analysis. This probeLcan selectively detect Al3+metal ionsviaa colorimetric as well as fluorescence turn-on strategy over other metal ions. Besides, the probe can also detect the aluminium ions in pharmaceutical tablets. The resultingL-Al3+ensemble has been exploited as a turn-off fluorescence sensor for the detection of pyrophosphate (PPi) anion through metal displacement or by using a decomplexation approach. Based on reversible “off-on-off” emission characteristics, the probe was applied for the construction of molecular logic gates and the development of a paper strip kit for on-site detection applications. In addition, this ensemble can also be utilized to detect PPi released during DNA synthesis and biological extracts, and in live cells.

Original languageEnglish
Pages (from-to)6067-6079
Number of pages13
JournalNew Journal of Chemistry
Volume45
Issue number13
DOIs
Publication statusPublished - 2021 Apr 7

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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