A new model for predicting the timing of leukapheresis on the basis of CD34+ cell and hematopoietic progenitor cell levels

Hao Wei Teng, Liang Tsai Hsiao, Shu Chou Chaou, Jyh Pyng Gau, Tzu Chi Lee, Ying Yih Shih, Chun Yu Liu, Ying Chung Hong, Ming Huang Chen, Mu Hsin Chang, Ya Hsu Yang, Po Min Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We developed a model (depending on peripheral CD34+ cell count and hematopoietic progenitor cell count) to determine the optimal timing of 3-day leukapheresis in patients pretreated with chemotherapy and G-CSF. Marrow potentials were identified on the basis of three patterns of leukapheretic yield. Pattern 1 predicted good marrow potential. The positive predictive value of a first-day leukapheretic yield of >1 × 106 CD34 + cells/kg (mean 3-day yield = 8.18 × 106 CD34 + cells/kg, n = 11) was 100%. Pattern 2 predicted poor marrow potential. The negative predictive value of a 3-day leukapheretic yield of >1 × 106 CD34+ cells/kg (3-day yield = 0.26 × 106 CD34+ cells/kg, n = 1) was 100%. Pattern 3 met neither of the above criteria (mean 3-day yield = 1.37 × 106 CD34 + cells/kg, n = 19). The marrow potential was borderline and patients could be further divided into two subgroups according to peripheral CD34 + cell counts when WBC reached >10,000/μ1. The mean yield differed significantly between pattern 1 and 3 (P < 0.001). For patients with good marrow potential, leukapheresis should begin as soon as the WBC count is >5,000/μ1. Patients with borderline marrow potential may benefit from delaying leukapheresis until the WBC level is >10,000/μ1 and leukapheresis extended more than 3 days.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalJournal of Clinical Apheresis
Volume22
Issue number4
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Antigens
  • CD34
  • Evaluation studies
  • Hematopoietic stem cells
  • Leukapheresis
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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