A new approach for the prevention and treatment of Helicobacter pylori infection via upregulation of autophagy and downregulation of apoptosis

Jyh Chin Yang, Chiang Ting Chien

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Helicobacter pylori infection plays a crucial role in the pathogenesis of peptic ulcer and gastric cancer. The current proton pump inhibitor-based triple regimens or second-line therapies for the eradication of Helicobacter pylori face an increase in resistance problems, demanding a search for novel candidates. A new strategy for reduction of Helicobacter pylori infection is to interfere with the interaction between bacteria and target cells and to kill the bacteria but not target cells at the same time. By this approach, we found that the combination of anti-adhesion, antibacteria, antioxidant agents like sialic acid and catechins have a protective potential against Helicobacter pylori-induced gastric injury via a biphasic response in apoptosis and autophagy. The combination of sialic acid and catechins induced an upregulation in autophagy and a downregulation in apoptosis in the Helicobacter pylori-infected gastric epithelium and efficiently reduced gastric inflammation. It appears that a novel agent or a combination of several agents can be utilized to protect against Helicobacter pylori-induced gastric injury via the mechanism of upregulation of survival-related autophagy and downregulation of death-related apoptosis.

Original languageEnglish
Pages (from-to)413-414
Number of pages2
JournalAutophagy
Volume5
Issue number3
DOIs
Publication statusPublished - 2009 Apr 1

Fingerprint

Autophagy
Helicobacter Infections
Helicobacter pylori
Up-Regulation
Down-Regulation
Apoptosis
Stomach
Catechin
N-Acetylneuraminic Acid
Bacteria
Proton Pump Inhibitors
Wounds and Injuries
Peptic Ulcer
Stomach Neoplasms
Epithelium
Antioxidants
Inflammation

Keywords

  • Anti-adhesion
  • Antibacteria
  • Antioxidant
  • Apoptosis
  • Autophagy
  • Catechins
  • Helicobacter pylori
  • Sialic acid

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

A new approach for the prevention and treatment of Helicobacter pylori infection via upregulation of autophagy and downregulation of apoptosis. / Yang, Jyh Chin; Chien, Chiang Ting.

In: Autophagy, Vol. 5, No. 3, 01.04.2009, p. 413-414.

Research output: Contribution to journalArticle

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