TY - JOUR
T1 - A nationwide population-based retrospective cohort study
T2 - Decreased risk of stroke in cervical cancer patients after receiving treatment
AU - Chang, Wei Chun
AU - Muo, Chih Hsin
AU - Chang, Shih Ni
AU - Sung, Fung Chang
AU - Chang, Yen Jung
AU - Kao, Chia Hung
N1 - Funding Information:
This study was partly supported by grants from the study hospital (DMR-101-061 and DMR-100-076), Taiwan Department of Health Clinical Trial and Research Center for Excellence (DOH102-TD-B-111-004), and Taiwan Department of Health Cancer Research Center for Excellence (DOH102-TD-C-111-005).
PY - 2013/10
Y1 - 2013/10
N2 - Objective: To evaluate risk of stroke in patients with cervical cancer using population-based data. Methods: Claims collected in the Taiwan National Health Insurance database were used to identify 20,286 cervical cancer patients receiving diagnosis and treatment during 2000-2008. A reference group of 81,144 non-cancer participants, matched for age, cervical cancer-month and cervical cancer-year, was used for comparison. Risk of stroke was further assessed at follow-up until the end of 2009. Results: Patients with cervical cancer had a 42 % lower risk of developing stroke compared with the cancer-free reference population. Increased risk of stroke was observed in patients receiving radiotherapy compared with the surgery treatment group (HR = 1.88, 95 % CI = 1.52-2.32). Conclusion: Results from this large retrospective cohort study indicate a lower risk of developing stroke in cervical cancer patients after receiving treatment compared with a reference population free of cancer after adjusted for age, sex, urbanization level, and stroke risk factors including hypertension and diabetes. Supplementation of estrogen after cancer treatment could explain this finding. Further prospective randomized controlled analysis is needed to confirm these findings and to elucidate the underlying biological mechanisms.
AB - Objective: To evaluate risk of stroke in patients with cervical cancer using population-based data. Methods: Claims collected in the Taiwan National Health Insurance database were used to identify 20,286 cervical cancer patients receiving diagnosis and treatment during 2000-2008. A reference group of 81,144 non-cancer participants, matched for age, cervical cancer-month and cervical cancer-year, was used for comparison. Risk of stroke was further assessed at follow-up until the end of 2009. Results: Patients with cervical cancer had a 42 % lower risk of developing stroke compared with the cancer-free reference population. Increased risk of stroke was observed in patients receiving radiotherapy compared with the surgery treatment group (HR = 1.88, 95 % CI = 1.52-2.32). Conclusion: Results from this large retrospective cohort study indicate a lower risk of developing stroke in cervical cancer patients after receiving treatment compared with a reference population free of cancer after adjusted for age, sex, urbanization level, and stroke risk factors including hypertension and diabetes. Supplementation of estrogen after cancer treatment could explain this finding. Further prospective randomized controlled analysis is needed to confirm these findings and to elucidate the underlying biological mechanisms.
KW - Cervical cancer
KW - Population-based study
KW - Stroke risk
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U2 - 10.1007/s00404-013-2827-7
DO - 10.1007/s00404-013-2827-7
M3 - Article
C2 - 23568013
AN - SCOPUS:84885380712
SN - 0932-0067
VL - 288
SP - 867
EP - 871
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 4
ER -
