A mild and convenient one-pot two-step synthesis of hydroxy- iminodihydrobenzofurans mediated by silica gel under microwave activation conditions

Deepak Kumar Barange, B. Rama Raju, Veerababurao Kavala, Chun Wei Kuo, Yu Chen Tu, Ching Fa Yao

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26 Citations (Scopus)


A convenient one-pot two-step procedure for the synthesis of hydroxyiminodihydrobenzofurans assisted by microwave irradiation in presence of silica gel is described herein. Cyclic 1,3-dicarbonyl compounds reacted smoothly with various nitroolefins to furnish hydroxyiminodihydrobenzofuran derivatives as the mixture of E and Z isomers. Clean reaction conditions, no work-up procedure, easy isolation and good yields of the products are the salient features of the methodology.

Original languageEnglish
Pages (from-to)3754-3760
Number of pages7
Issue number21
Publication statusPublished - 2010 May 22


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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