A genetic model for cardiac pattern formation and cell fate determination

Wendy K. Lockwood, Margaret Liu, Ming Tsan Su, Rolf Bodmer

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

The Drosophila heart shares many embryological and molecular similarities with those of vertebrates despite the morphological differences of the final products. For example, their mesodermal origin and initial assembly into a linear heart tube are comparable in many respects. Moreover, numerous gene functions have been identified that are utilized by both vertebrates and Drosophila for the specification and differentiation of the heart progenitor cells. Because of the simplicity in structure and the wealth of genetic tools available, the Drosophila heart has emerged as a pioneering model system for elucidating the molecular basis of heart development.

Original languageEnglish
Title of host publicationGenetic Models in Cardiorespiratory Biology
PublisherCRC Press
Pages179-202
Number of pages24
ISBN (Electronic)9780824746056
ISBN (Print)9780824705121
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lockwood, W. K., Liu, M., Su, M. T., & Bodmer, R. (2001). A genetic model for cardiac pattern formation and cell fate determination. In Genetic Models in Cardiorespiratory Biology (pp. 179-202). CRC Press. https://doi.org/10.1201/b14019