A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Wei Ming Chen; Herming Chiueh; Tsan Jieh Chen; Chia Lun Ho; Chi Jeng; Shun Ting Chang; Ming Dou Ker; Chun Yu Lin; Ya Chun Huang; Chia Wei Chou; Tsun Yuan Fan; Ming Seng Cheng; Sheng Fu Liang; Tzu Chieh Chien; Sih Yen Wu; Yu Lin Wang; Fu Zen Shaw; Yu Hsing Huang; Chia Hsiang Yang; Jin Chern Chiou; Chih Wei Chang; Lei Chun Chou; Chung Yu Wu

doi:10.1109/ISSCC.2013.6487737

A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

Wei Ming Chen^*, Herming Chiueh, Tsan Jieh Chen, Chia Lun Ho, Chi Jeng, Shun Ting Chang, Ming Dou Ker, Chun Yu Lin, Ya Chun Huang, Chia Wei Chou, Tsun Yuan Fan, Ming Seng Cheng, Sheng Fu Liang, Tzu Chieh Chien, Sih Yen Wu, Yu Lin Wang, Fu Zen Shaw, Yu Hsing Huang, Chia Hsiang Yang, Jin Chern ChiouChih Wei Chang, Lei Chun Chou, Chung Yu Wu

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

49 Citations (Scopus)

Abstract

Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.

Original language	English
Title of host publication	2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers
Pages	286-287
Number of pages	2
DOIs	https://doi.org/10.1109/ISSCC.2013.6487737
Publication status	Published - 2013
Externally published	Yes
Event	2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013 - San Francisco, CA, United States Duration: 2013 Feb 17 → 2013 Feb 21

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	56
ISSN (Print)	0193-6530

Other

Other	2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013
Country/Territory	United States
City	San Francisco, CA
Period	2013/02/17 → 2013/02/21

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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10.1109/ISSCC.2013.6487737

Cite this

Chen, W. M., Chiueh, H., Chen, T. J., Ho, C. L., Jeng, C., Chang, S. T., Ker, M. D., Lin, C. Y., Huang, Y. C., Chou, C. W., Fan, T. Y., Cheng, M. S., Liang, S. F., Chien, T. C., Wu, S. Y., Wang, Y. L., Shaw, F. Z., Huang, Y. H., Yang, C. H., ... Wu, C. Y. (2013). A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. In 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers (pp. 286-287). Article 6487737 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 56). https://doi.org/10.1109/ISSCC.2013.6487737

A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. / Chen, Wei Ming; Chiueh, Herming; Chen, Tsan Jieh et al.
2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers. 2013. p. 286-287 6487737 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 56).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chen, WM, Chiueh, H, Chen, TJ, Ho, CL, Jeng, C, Chang, ST, Ker, MD, Lin, CY, Huang, YC, Chou, CW, Fan, TY, Cheng, MS, Liang, SF, Chien, TC, Wu, SY, Wang, YL, Shaw, FZ, Huang, YH, Yang, CH, Chiou, JC, Chang, CW, Chou, LC & Wu, CY 2013, A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. in 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers., 6487737, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 56, pp. 286-287, 2013 60th IEEE International Solid-State Circuits Conference, ISSCC 2013, San Francisco, CA, United States, 2013/02/17. https://doi.org/10.1109/ISSCC.2013.6487737

Chen WM, Chiueh H, Chen TJ, Ho CL, Jeng C, Chang ST et al. A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control. In 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers. 2013. p. 286-287. 6487737. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). doi: 10.1109/ISSCC.2013.6487737

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abstract = "Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.",

author = "Chen, {Wei Ming} and Herming Chiueh and Chen, {Tsan Jieh} and Ho, {Chia Lun} and Chi Jeng and Chang, {Shun Ting} and Ker, {Ming Dou} and Lin, {Chun Yu} and Huang, {Ya Chun} and Chou, {Chia Wei} and Fan, {Tsun Yuan} and Cheng, {Ming Seng} and Liang, {Sheng Fu} and Chien, {Tzu Chieh} and Wu, {Sih Yen} and Wang, {Yu Lin} and Shaw, {Fu Zen} and Huang, {Yu Hsing} and Yang, {Chia Hsiang} and Chiou, {Jin Chern} and Chang, {Chih Wei} and Chou, {Lei Chun} and Wu, {Chung Yu}",

year = "2013",

doi = "10.1109/ISSCC.2013.6487737",

language = "English",

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AU - Chen, Wei Ming

AU - Chiueh, Herming

AU - Chen, Tsan Jieh

AU - Ho, Chia Lun

AU - Jeng, Chi

AU - Chang, Shun Ting

AU - Ker, Ming Dou

AU - Lin, Chun Yu

AU - Huang, Ya Chun

AU - Chou, Chia Wei

AU - Fan, Tsun Yuan

AU - Cheng, Ming Seng

AU - Liang, Sheng Fu

AU - Chien, Tzu Chieh

AU - Wu, Sih Yen

AU - Wang, Yu Lin

AU - Shaw, Fu Zen

AU - Huang, Yu Hsing

AU - Yang, Chia Hsiang

AU - Chiou, Jin Chern

AU - Chang, Chih Wei

AU - Chou, Lei Chun

AU - Wu, Chung Yu

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AB - Epilepsy is one of the most common neurological disorders. Around 1% of the world's population is affected, and nearly 25% of the patients cannot be treated by available therapies. Recently, seizure-triggered feedback electrical stimulation has been proved to effectively suppress pathological brain activities [1], but devices with accurate detection and effective stimulation for real-time seizure control are still unavailable. In this paper, a fully integrated 8-channel closed-loop seizure-control SoC with entropy-and-spectrum- aided seizure detection and adaptive neural stimulation is presented. This chip is powered wirelessly, aiming for implantable devices. The functionality of the fabricated chip is verified in animal tests.

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BT - 2013 IEEE International Solid-State Circuits Conference, ISSCC 2013 - Digest of Technical Papers

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ER -

A fully integrated 8-channel closed-loop neural-prosthetic SoC for real-time epileptic seizure control

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