A discrete five-coordinate NiIII complex resembling the active site of the oxidized form of nickel superoxide dismutase

Way Zen Lee; Chien Wei Chiang; Tsung Han Lin; Ting Shen Kuo

doi:10.1002/chem.201102690

A discrete five-coordinate Ni^III complex resembling the active site of the oxidized form of nickel superoxide dismutase

Way Zen Lee^*
, Chien Wei Chiang
, Tsung Han Lin
, Ting Shen Kuo

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Nickel biomimic: A pentadentate ligand, 2,6-bis(((S)-2- (diphenylhydroxymethyl)-1-pyrrolidinyl)methyl)pyridine (H₂BDPP), was deprotonated and subsequently reacted with [Ni(CH₃CN) ₆](ClO₄)₂ to give Ni(BDPP) (1). A square-pyramidal Ni^III complex, [Ni(BDPP)](PF₆) (2), was obtained via oxidation of 1. Complex 2 can oxidize O₂^- into O₂ and its EPR spectrum is similar to that of the oxidized form of NiSOD.

Original language	English
Pages (from-to)	50-53
Number of pages	4
Journal	Chemistry - A European Journal
Volume	18
Issue number	1
DOIs	https://doi.org/10.1002/chem.201102690
Publication status	Published - 2012 Jan 2

Keywords

biomimetic synthesis
nickel
pentadentate ligands
superoxide degradation
superoxide dismutase

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201102690

Cite this

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title = "A discrete five-coordinate NiIII complex resembling the active site of the oxidized form of nickel superoxide dismutase",

abstract = "Nickel biomimic: A pentadentate ligand, 2,6-bis(((S)-2- (diphenylhydroxymethyl)-1-pyrrolidinyl)methyl)pyridine (H2BDPP), was deprotonated and subsequently reacted with [Ni(CH3CN) 6](ClO4)2 to give Ni(BDPP) (1). A square-pyramidal NiIII complex, [Ni(BDPP)](PF6) (2), was obtained via oxidation of 1. Complex 2 can oxidize O2- into O2 and its EPR spectrum is similar to that of the oxidized form of NiSOD.",

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AU - Lin, Tsung Han

AU - Kuo, Ting Shen

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AB - Nickel biomimic: A pentadentate ligand, 2,6-bis(((S)-2- (diphenylhydroxymethyl)-1-pyrrolidinyl)methyl)pyridine (H2BDPP), was deprotonated and subsequently reacted with [Ni(CH3CN) 6](ClO4)2 to give Ni(BDPP) (1). A square-pyramidal NiIII complex, [Ni(BDPP)](PF6) (2), was obtained via oxidation of 1. Complex 2 can oxidize O2- into O2 and its EPR spectrum is similar to that of the oxidized form of NiSOD.

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KW - nickel

KW - pentadentate ligands

KW - superoxide degradation

KW - superoxide dismutase

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