A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[b,f]1,8-naphthyridine Derivatives

Bharath Kumar Villuri, Ashok Konala, Veerababurao Kavala, Trimurtulu Kotipalli, Chun Wei Kuo, Ching-Fa Yao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The synthesis of some dibenzo[b,f]-[1,8]naphthyridine derivatives in a cascade manner is reported. The reaction includes a Knovenagel condensation, the insertion of a nitrile and an alkyne into an N–H bond and an oxidation/oxidative C–C bond cleavage sequence in the presence of copper iodide. The key 1,8-naphthyridine core was constructed in a cascade manner during the course of the reaction itself which allows diverse dibenzo[b,f]-[1,8]naphthyridine derivatives to be readily prepared. (Figure presented.).

Original languageEnglish
Pages (from-to)3142-3153
Number of pages12
JournalAdvanced Synthesis and Catalysis
Volume359
Issue number18
DOIs
Publication statusPublished - 2017 Sep 18

Fingerprint

Naphthyridines
Copper
Derivatives
Condensation
Nitriles
Alkynes
Iodides
Oxidation

Keywords

  • 1,8-naphthyridines
  • aurora kinase inhibitor
  • cascade reaction
  • hydroamination
  • tandem insertion

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[b,f]1,8-naphthyridine Derivatives. / Villuri, Bharath Kumar; Konala, Ashok; Kavala, Veerababurao; Kotipalli, Trimurtulu; Kuo, Chun Wei; Yao, Ching-Fa.

In: Advanced Synthesis and Catalysis, Vol. 359, No. 18, 18.09.2017, p. 3142-3153.

Research output: Contribution to journalArticle

Villuri, Bharath Kumar ; Konala, Ashok ; Kavala, Veerababurao ; Kotipalli, Trimurtulu ; Kuo, Chun Wei ; Yao, Ching-Fa. / A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[b,f]1,8-naphthyridine Derivatives. In: Advanced Synthesis and Catalysis. 2017 ; Vol. 359, No. 18. pp. 3142-3153.
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