A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose

Tun Cheng Chien; Ji Wang Chern

doi:10.1016/j.carres.2004.01.010

A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose

Tun Cheng Chien, Ji Wang Chern^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The lipase from Candida rugosa (Sigma) was used to catalyze the regioselective deacetylation at the 5-position of 1,2,3,5-tetra-O-acetyl-β- D-ribofuranose on a preparative scale. Enzymatic deacetylation provides a convenient one-step preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose.

Original language	English
Pages (from-to)	1215-1217
Number of pages	3
Journal	Carbohydrate Research
Volume	339
Issue number	6
DOIs	https://doi.org/10.1016/j.carres.2004.01.010
Publication status	Published - 2004 Apr 28
Externally published	Yes

Keywords

Deacetylation
Deprotection
Lipase
Regioselective
Ribofuranose

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.carres.2004.01.010

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title = "A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose",

abstract = "The lipase from Candida rugosa (Sigma) was used to catalyze the regioselective deacetylation at the 5-position of 1,2,3,5-tetra-O-acetyl-β- D-ribofuranose on a preparative scale. Enzymatic deacetylation provides a convenient one-step preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose.",

keywords = "Deacetylation, Deprotection, Lipase, Regioselective, Ribofuranose",

author = "Chien, {Tun Cheng} and Chern, {Ji Wang}",

note = "Funding Information: This investigation was supported by a research grant (NSC90-2321-B002-002) from the National Science Council of Taiwan.",

year = "2004",

month = apr,

day = "28",

doi = "10.1016/j.carres.2004.01.010",

language = "English",

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T1 - A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose

AU - Chien, Tun Cheng

AU - Chern, Ji Wang

N1 - Funding Information: This investigation was supported by a research grant (NSC90-2321-B002-002) from the National Science Council of Taiwan.

PY - 2004/4/28

Y1 - 2004/4/28

N2 - The lipase from Candida rugosa (Sigma) was used to catalyze the regioselective deacetylation at the 5-position of 1,2,3,5-tetra-O-acetyl-β- D-ribofuranose on a preparative scale. Enzymatic deacetylation provides a convenient one-step preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose.

AB - The lipase from Candida rugosa (Sigma) was used to catalyze the regioselective deacetylation at the 5-position of 1,2,3,5-tetra-O-acetyl-β- D-ribofuranose on a preparative scale. Enzymatic deacetylation provides a convenient one-step preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose.

KW - Deacetylation

KW - Deprotection

KW - Lipase

KW - Regioselective

KW - Ribofuranose

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DO - 10.1016/j.carres.2004.01.010

M3 - Article

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SN - 0008-6215

VL - 339

SP - 1215

EP - 1217

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 6

ER -

A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose

Abstract

Keywords

ASJC Scopus subject areas

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