A convenient preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose by enzymatic regioselective 5-O-deacetylation of the peracetylated ribofuranose

Tun Cheng Chien, Ji Wang Chern

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The lipase from Candida rugosa (Sigma) was used to catalyze the regioselective deacetylation at the 5-position of 1,2,3,5-tetra-O-acetyl-β- D-ribofuranose on a preparative scale. Enzymatic deacetylation provides a convenient one-step preparation of 1,2,3-tri-O-acetyl-β-D-ribofuranose.

Original languageEnglish
Pages (from-to)1215-1217
Number of pages3
JournalCarbohydrate Research
Volume339
Issue number6
DOIs
Publication statusPublished - 2004 Apr 28

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Keywords

  • Deacetylation
  • Deprotection
  • Lipase
  • Regioselective
  • Ribofuranose

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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