Abstract
A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3- (phenylthiomethyl)quinolines were transformed into 2-methyl-3- (phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation
Original language | English |
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Pages (from-to) | 5081-5094 |
Number of pages | 14 |
Journal | Molecules |
Volume | 17 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2012 May |
Keywords
- Fe/AcOH
- Morita-Baylis-Hillman adducts
- One-pot procedure
- Quinolines
- Reductive cyclization
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry