A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones

Chintakunta Ramesh, Po Min Lei, Veerababurao Kavala, Chun Wei Kuo, Ching Fa Yao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3- (phenylthiomethyl)quinolines were transformed into 2-methyl-3- (phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation

Original languageEnglish
Pages (from-to)5081-5094
Number of pages14
JournalMolecules
Volume17
Issue number5
DOIs
Publication statusPublished - 2012 May 1

Fingerprint

Quinolines
Sulfones
Oxidation
Cyclization
Sulfhydryl Compounds

Keywords

  • Fe/AcOH
  • Morita-Baylis-Hillman adducts
  • One-pot procedure
  • Quinolines
  • Reductive cyclization

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones. / Ramesh, Chintakunta; Lei, Po Min; Kavala, Veerababurao; Kuo, Chun Wei; Yao, Ching Fa.

In: Molecules, Vol. 17, No. 5, 01.05.2012, p. 5081-5094.

Research output: Contribution to journalArticle

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