A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones

Chintakunta Ramesh; Po Min Lei; Veerababurao Kavala; Chun Wei Kuo; Ching Fa Yao

doi:10.3390/molecules17055081

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones

Chintakunta Ramesh, Po Min Lei, Veerababurao Kavala, Chun Wei Kuo, Ching Fa Yao

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3- (phenylthiomethyl)quinolines were transformed into 2-methyl-3- (phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation

Original language	English
Pages (from-to)	5081-5094
Number of pages	14
Journal	Molecules
Volume	17
Issue number	5
DOIs	https://doi.org/10.3390/molecules17055081
Publication status	Published - 2012 May

Keywords

Fe/AcOH
Morita-Baylis-Hillman adducts
One-pot procedure
Quinolines
Reductive cyclization

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules17055081

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A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones. / Ramesh, Chintakunta; Lei, Po Min; Kavala, Veerababurao; Kuo, Chun Wei; Yao, Ching Fa.

In: Molecules, Vol. 17, No. 5, 05.2012, p. 5081-5094.

Research output: Contribution to journal › Article › peer-review

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abstract = "A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3- (phenylthiomethyl)quinolines were transformed into 2-methyl-3- (phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation",

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AU - Kavala, Veerababurao

AU - Kuo, Chun Wei

AU - Yao, Ching Fa

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A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones

Abstract

Keywords

ASJC Scopus subject areas

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