A bioinspired copper-based coordination polymer for the detection of pheochromocytoma biomarkers

Sivasankar Kulandaivel, Chia Her Lin, Yi-Chun Yeh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidase-mimicking (catechol oxidase/laccase) nanozymes provide outstanding specificity in the detection of epinephrine (Epi) for the assessment of pheochromocytoma; however, epinephrine (Epi) and norepinephrine (NE) co-existing in the same systems will reduce the selectivity of the biosensor. In the current study, we synthesized copper-based coordination polymer (Cu-CP) nanozymes capable of accelerating the oxidation of Epi with high specificity. Furthermore, the Cu-CP is able to detect Epi over a wide linear range of 0.5–100 μM with a low detection limit of 0.36 μM while providing excellent stability and recyclability. Furthermore, we employed colorimetric and fluorescence signals for sequential detection of the coexistence of Epi and NE for use in tracking the treatment outcomes of patients with pheochromocytoma. Experiments using artificial urine further confirmed the efficacy of the proposed system.

Original languageEnglish
Article number124206
JournalTalanta
Volume255
DOIs
Publication statusPublished - 2023 Apr 1

Keywords

  • Bio-inspired
  • Colorimetric detection
  • Epinephrine
  • Norepinephrine
  • Oxidase mimicking nanozyme

ASJC Scopus subject areas

  • Analytical Chemistry

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