@article{637cffe73dfd470290626bcf380ab4a9,
title = "Aβ42 oligomers can seed the fibrillization of Aβ40 peptides",
abstract = "Aggregation of Aβ40 and Aβ42 are considered as pivotal players in the pathogenic mechanism of Alzheimer's disease. In this work, we applied reverse micelles formed by sodium bis(2-ethylhexyl) sulfosuccinate (AOT) to prepare oligomeric aggregates of Aβ40 or Aβ42 peptides. The resultant globular aggregates were approximately 22 nm in diameter and they were capable to form mature fibrils upon self-aggregation. Furthermore, we found that the Aβ42 oligomeric aggregates can seed the fibrillization of Aβ40 monomers. Solid-state NMR results revealed that the Aβ40 fibrils seeded by Aβ40 or Aβ42 oligomers adopt a similar molecular structure for the residues near the C-terminus.",
keywords = "beta amyloid, cross seeding, reverse micelles, solid-state NMR",
author = "Wu, {Yi Shan} and Huang, {Shing Jong} and Wu, {Meng Hsin} and Tu, {Ling Hsien} and Lee, {Ming Che} and Chan, {Jerry Chun Chung}",
note = "Funding Information: This work was financially supported by the Ministry of Science and Technology (MOST 108‐2113‐M‐002‐001). The TMV samples were kindly provided by Dr. Hsin‐Hung Yeh and Dr. Yi‐Shu Chiu (Agricultural Biotechnological Research Center, Academia Sinica). The NMR, TEM, and STEM measurements were carried out at the Instrumentation Center of National Taiwan University, supported by the Ministry of Science and Technology. The assistance of Ya‐Yun Yang in STEM measurements is gratefully acknowledged. Funding Information: Ministry of Science and Technology, Grant/Award Number: MOST 108‐2113‐M‐002‐001 Funding information Funding Information: This work was financially supported by the Ministry of Science and Technology (MOST 108-2113-M-002-001). The TMV samples were kindly provided by Dr. Hsin-Hung Yeh and Dr. Yi-Shu Chiu (Agricultural Biotechnological Research Center, Academia Sinica). The NMR, TEM, and STEM measurements were carried out at the Instrumentation Center of National Taiwan University, supported by the Ministry of Science and Technology. The assistance of Ya-Yun Yang in STEM measurements is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2022 Chemical Society Located in Taipei and Wiley-VCH GmbH.",
year = "2022",
month = aug,
doi = "10.1002/jccs.202200136",
language = "English",
volume = "69",
pages = "1318--1325",
journal = "Journal of the Chinese Chemical Society",
issn = "0009-4536",
publisher = "Chinese Chemical Society",
number = "8",
}