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• 2020

  ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17

  Lin, C. W., Fan, C. H., Chang, Y. C. & Hsieh-Li, H. M., 2020 Nov 1, In: Neuroscience Letters. 738, 135337.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Purkinje Cells
  • Gliosis
  • TATA-Box Binding Protein
  • Cerebellum

• Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

  Liao, J. F., Cheng, Y. F., You, S. T., Kuo, W. C., Huang, C. W., Chiou, J. J., Hsu, C. C., Hsieh-Li, H. M., Wang, S. & Tsai, Y. C., 2020, (Accepted/In press) In: Brain, Behavior, and Immunity. 90, p. 26-46 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lactobacillus plantarum
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Parkinson Disease
  • Gastrointestinal Microbiome
  • Eating
  1 Citation (Scopus)

• Neuroimaging Spectrum at Pre-, Early, and Late Symptomatic Stages of SCA17 Mice

  Chen, C. C., Yao, N. W., Lin, C. W., Su, W. S., Wu, C. T., Chang, C. & Hsieh-Li, H. M., 2020 Aug 1, In: Cerebellum. 19, 4, p. 487-500 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroimaging
  • Cerebellum
  • Nervous System Heredodegenerative Disorders
  • Atrophy
  • Disease Progression

• Survival Motor Neuron Protein Participates in Mouse Germ Cell Development and Spermatogonium Maintenance

  Chang, W. F., Xu, J., Lin, T. Y., Hsu, J., Hsieh-Li, H. M., Hwu, Y. M., Liu, J. L., Lu, C. H. & Sung, L. Y., 2020 Jan 25, In: International journal of molecular sciences. 21, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells
  • Spermatogonia
  • stem cells
  • maintenance
  • mice
  3 Citations (Scopus)

• Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

  Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 Jan 1, (Accepted/In press) In: Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

  Research output: Contribution to journal › Article › peer-review

  • PHA 767491
  • Inflammation
  • Glycogen Synthase Kinase 3
  • tributyl phosphate
  • Proteins
  2 Citations (Scopus)
• 2019

  Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

  Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 Feb 14, In: Psychopharmacology. 236, 2, p. 763-773 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N-(4-hydroxyphenyl)arachidonylamide
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Neuroprotection
  • Hyperglycemia
  6 Citations (Scopus)

• Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

  Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In: Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

  Research output: Contribution to journal › Article › peer-review

  • tropomyosin kinase
  • Low Density Lipoprotein Receptor-Related Protein-1
  • indole
  • Neuroprotection
  • Alzheimer Disease
  4 Citations (Scopus)

• MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ _25-35 -induced anxiety and cognitive deficits in a mouse model

  Huang, H. J., Huang, H. Y. & Hsieh-Li, H. M., 2019 Feb 1, In: CNS Neuroscience and Therapeutics. 25, 2, p. 175-186 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mocetinostat
  • Histone Deacetylase Inhibitors
  • Anxiety
  • Alzheimer Disease
  • 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide
  7 Citations (Scopus)

• Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

  Chiu, Y. J., Hsieh, Y. H., Lin, T. H., Lee, G. C., Hsieh-Li, H. M., Sun, Y. C., Chen, C. M., Chang, K. H. & Lee-Chen, G. J., 2019 May 1, In: Neurochemistry International. 125, p. 175-186 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuronal Outgrowth
  • Alzheimer Disease
  • Inflammation
  • Green Fluorescent Proteins
  • Acetylcholinesterase
  5 Citations (Scopus)

• Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice under Oligomeric Aβ-Induced Stress

  Huang, H. J., Huang, C. Y., Lee, M., Lin, J. Y. & Hsieh-Li, H. M., 2019 Jan 1, In: American Journal of Chinese Medicine. 47, 7, p. 1459-1481 23 p.

  Research output: Contribution to journal › Article › peer-review

  • Pueraria
  • Alzheimer Disease
  • puerarin
  • Anxiety
  • Herbal Medicine
  5 Citations (Scopus)

• Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

  Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019 Jan 1, In: Aging. 11, 3, p. 986-1007 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • Neuroprotection
  • polyglutamine
  • nuclear factor Y
  7 Citations (Scopus)
• 2018

  Administration of Momordica charantia enhances the neuroprotection and reduces the side effects of LiCl in the treatment of Alzheimer’s disease

  Huang, H. J., Chen, S. L., Chang, Y. T., Chyuan, J. H. & Hsieh-Li, H. M., 2018 Dec, In: Nutrients. 10, 12, 1888.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Momordica charantia
  • Lithium Chloride
  • lithium chloride
  • Alzheimer disease
  • Neuroprotection
  7 Citations (Scopus)

• The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

  Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In: NeuroToxicology. 67, p. 259-269 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • indole
  • Neuronal Outgrowth
  • Agglomeration
  11 Citations (Scopus)
• 2017

  Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

  Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 Aug 1, In: Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Thermodynamics
  • Assays
  • Molecular Dynamics Simulation
  • Molecular dynamics
  • Phosphotransferases
  5 Citations (Scopus)

• Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease

  Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 Feb 1, In: Kidney International. 91, 2, p. 412-422 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipocalin-2
  • Polycystic Kidney Diseases
  • Longevity
  • Cysts
  • Kidney
  5 Citations (Scopus)

• The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

  Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 Jan 1, In: CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • fluorescent protein 583
  • Neuronal Outgrowth
  • Alzheimer Disease
  • Solubility
  10 Citations (Scopus)