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2020
Copper-catalysed synthesis of 3-hydroxyisoindolin-1-ones from benzylcyanide 2-iodobenzamides
Kavala, V., Wang, C. Y., Wang, C. C., Patil, P. B., Fang, C. C., Kuo, C. W. & Yao, C. F., 2020 Jan 1, In: Organic and Biomolecular Chemistry. 18, 5, p. 988-998 11 p.Research output: Contribution to journal › Article › peer-review
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Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation
Chiu, Y. J., Lin, S. A., Chen, W. L., Lin, T. H., Lin, C. H., Yao, C. F., Lin, W., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 Dec, In: Aging. 12, 23, p. 23619-23646 28 p.Research output: Contribution to journal › Article › peer-review
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Synthesis of Pyrido[2,3-b]indoles via Brønsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates
Yang, T. H., Kavala, V., Kuo, C. W. & Yao, C. F., 2020 Jul 1, In: Asian Journal of Organic Chemistry. 9, 7, p. 1053-1058 6 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
2019
A Synthetic Strategy for the Construction of Functionalized Triphenylene Frameworks via Palladium Catalyzed Intramolecular Annulation/Decyanogenative C-H Bond Alkenylation
Ichake, S. S., Villuri, B. K., Reddy, S. R., Kavala, V. & Yao, C. F., 2019 Jan 1, In: Organic Letters. 21, 7, p. 2256-2260 5 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement
Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In: Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Microwave-Assisted Ruthenium(II)-Catalyzed C−H/N−O Activation of N-Methoxybenzamides with Alkynylsulfane
Sarathkumar, S., Kavala, V. & Yao, C. F., 2019 Oct 1, In: Asian Journal of Organic Chemistry. 8, 10, p. 1830-1833 4 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models
Wei, P. C., Lee-Chen, G. J., Chen, C. M., Wu, Y. R., Chen, Y. J., Lin, J. L., Lo, Y. S., Yao, C. F. & Chang, K. H., 2019, In: Oxidative medicine and cellular longevity. 2019, 5074367.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Synthesis of Polysubstituted Cyclopentene and Cyclopenta[ b]carbazole Analogues from Unsymmetrical 4-Arylidene-3,6-diarylhex-2-en-5-ynal and Indole Derivatives via an Iodine Mediated Electrocyclization Reaction
Bandi, V., Kavala, V., Konala, A., Hsu, C. H., Villuri, B. K., Reddy, S. R., Lin, L., Kuo, C. W. & Yao, C. F., 2019 Mar 15, In: Journal of Organic Chemistry. 84, 6, p. 3036-3044 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
2018
A triazole-conjugated benzoxazone induces reactive oxygen species and promotes autophagic apoptosis in human lung cancer cells
Hsieh, C. H., Wang, J. P., Chiu, C. C., Liu, C. Y., Yao, C. F. & Fang, K., 2018 Jan 1, In: Apoptosis. 23, 1Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Copper-Catalyzed Cascade Synthesis of 2-Aryl-3-cyanobenzofuran and Dibenzo[ b, f]oxepine-10-carbonitrile Derivatives
Villuri, B. K., Ichake, S. S., Reddy, S. R., Kavala, V., Bandi, V., Kuo, C. W. & Yao, C. F., 2018 Sep 7, In: Journal of Organic Chemistry. 83, 17, p. 10241-10247 7 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction
Kavala, V., Yang, Z., Konala, A., Yang, T. H., Kuo, C. W., Ruan, J. Y. & Yao, C. F., 2018 Mar 14, In: European Journal of Organic Chemistry. 2018, 10, p. 1241-1247 7 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice
Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In: NeuroToxicology. 67, p. 259-269 11 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
2017
A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[b,f]1,8-naphthyridine Derivatives
Villuri, B. K., Konala, A., Kavala, V., Kotipalli, T., Kuo, C. W. & Yao, C. F., 2017 Sep 18, In: Advanced Synthesis and Catalysis. 359, 18, p. 3142-3153 12 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres
Ni, Y. L., Hsieh, C. H., Kim, S. H., Wang, J. P., Su, C. L., Yao, C. F. & Fang, K., 2017 Oct 1, In: Apoptosis. 22, 10, p. 1235-1245 11 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Palladium-catalyzed tandem C-H functionalization/cyclization strategy for the synthesis of 5-hydroxybenzofuran derivatives
Ichake, S. S., Konala, A., Kavala, V., Kuo, C. W. & Yao, C. F., 2017 Jan 6, In: Organic Letters. 19, 1, p. 54-57 4 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Regioselective switching approach for the synthesis of α and δ carboline derivatives
Yang, T. H., Kuo, C. W., Kavala, V., Konala, A., Huang, C. Y. & Yao, C. F., 2017, In: Chemical Communications. 53, 10, p. 1676-1679 4 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2-Iodobenzamide Derivatives and 2-Iodobenzylcyanides
Kavala, V., Yang, Z., Konala, A., Huang, C. Y., Kuo, C. W. & Yao, C. F., 2017 Jul 21, In: Journal of Organic Chemistry. 82, 14, p. 7280-7286 7 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction
Huang, C. Y., Kavala, V., Kuo, C. W., Konala, A., Yang, T. H. & Yao, C. F., 2017 Feb 17, In: Journal of Organic Chemistry. 82, 4, p. 1961-1968 8 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and their application in the synthesis of trisubstituted pyridines
Bandi, V., Kavala, V., Hsu, C. H., Konala, A., Villuri, B. K., Kotipalli, T., Kuo, C. W. & Yao, C. F., 2017, In: RSC Advances. 7, 74, p. 46704-46712 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1
Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 Jan 1, In: CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction
Su, C. L., Tseng, C. L., Ramesh, C., Liu, H. S., Huang, C. Y. F. & Yao, C. F., 2017, In: European Journal of Medicinal Chemistry. 132, p. 90-107 18 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2016
An indolylquinoline derivative activates DNA damage response and apoptosis in human hepatocellular carcinoma cells
Liu, C. Y., Hsieh, C. H., Kim, S. H., Wang, J. P., Ni, Y. L., Su, C-L., Yao, C. F. & Fang, K., 2016 Dec, In: International Journal of Oncology. 49, 6, p. 2431-2441 11 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Atriazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
Hsieh, C. H., Lee, L. C., Leong, W. Y., Yang, T. C., Yao, C. F. & Fang, K., 2016 Sep 14, In: Drug Design, Development and Therapy. 10, p. 2947-2957 11 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
N-Bromosuccinimide-Mediated Thiocyanation of Cyclohexene-Fused Isoxazoline N-Oxides
Ichake, S. S., Rajawinslin, R. R., Kavala, V., Villuri, B. K., Yang, H. T., Kuo, C. W. & Yao, C-F., 2016 Mar 1, In: Asian Journal of Organic Chemistry. 5, 3, p. 343-352 10 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4-Oxadiazole/1,3,4-Oxadiazoline and 1,2,4-Triazole Derivatives from N-Substituted Hydrazides
Kotipalli, T., Kavala, V., Konala, A., Janreddy, D., Kuo, C. W. & Yao, C. F., 2016 Aug 18, In: Advanced Synthesis and Catalysis. 358, 16, p. 2652-2660 9 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Syntheses of 2-Benzylbenzofuran Derivatives and 2-Aryl-nitrochroman Derivatives from Nitroalkene Precursors
Huang, C. Y., Kuo, C. W., Kavala, V. & Yao, C. F., 2016 May 1, In: European Journal of Organic Chemistry. 2016, 15, p. 2720-2734 15 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Synthesis of 2,3-Disubstituted Quinazolinone Derivatives through Copper Catalyzed C-H Amidation Reactions
Kotipalli, T., Kavala, V., Janreddy, D., Bandi, V., Kuo, C. W. & Yao, C. F., 2016 Feb 1, In: European Journal of Organic Chemistry. 2016, 6, p. 1182-1193 12 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Synthesis of 3-arylindole derivatives from nitroalkane precursors
Huang, C. Y., Kuo, C. W., Konala, A., Yang, T. H., Lin, L., Chen, Y. W., Kavala, V. & Yao, C. F., 2016 Jan 1, In: RSC Advances. 6, 98, p. 96049-96056 8 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Synthesis of benzo[: A] carbazole derivatives from 3-ethylindoles by exploiting the dual character of benzoquinone as an oxidizing agent and dienophile
Kuo, C. W., Konala, A., Lin, L., Chiang, T. T., Huang, C. Y., Yang, T. H., Kavala, V. & Yao, C. F., 2016 Jan 1, In: Chemical Communications. 52, 50, p. 7870-7873 4 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Synthesis of spiro isoindolinone-indolines and 1,2-disubstituted indoles from 2-iodobenzamide derivatives
Villuri, B. K., Kotipalli, T., Kavala, V., Ichake, S. S., Bandi, V., Kuo, C. W. & Yao, C. F., 2016 Jan 1, In: RSC Advances. 6, 78, p. 74845-74858 14 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity
Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C. H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C. F., Huang, H. J., Lee-Chen, G. J., Lee, M. C. & Hsieh-Li, H. M., 2016 Feb 1, In: Neuropharmacology. 101, p. 309-319 11 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2015
An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions
Liu, C. Y., Wu, P. T., Wang, J. P., Fan, P. W., Hsieh, C. H., Su, C. L., Chiu, C. C., Yao, C. F. & Fang, K., 2015 Nov 30, In: Apoptosis. 20, 11, p. 1471-1482 12 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo[b,j][1,7]phenanthroline derivatives via intramolecular reductive cyclization
Rajawinslin, R. R., Ichake, S. S., Kavala, V., Gawande, S. D., Huang, Y. H., Kuo, C. W. & Yao, C. F., 2015, In: RSC Advances. 5, 64, p. 52141-52153 13 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
One-pot synthesis of 2-arylquinazolines and tetracyclic isoindolo[1,2-a]quinazolines via cyanation followed by rearrangement of ortho-substituted 2-halo-N-arylbenzamides
Gawande, S. D., Zanwar, M. R., Kavala, V., Kuo, C. W., Rajawinslin, R. R. & Yao, C-F., 2015 Dec 4, In: Advanced Synthesis and Catalysis. 357, 1, p. 168-176 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl
Chen, W. C., Lin, C. C., Kavala, V., Kuo, C. W., Huang, C. Y. & Yao, C. F., 2015 Dec 15, In: Molecules. 20, 12, p. 22499-22519 21 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition
Chen, W. C., Kavala, V., Shih, Y. H., Wang, Y. H., Kuo, C. W., Yang, T. H., Huang, C. Y., Chiu, H. H. & Yao, C. F., 2015 Jun 1, In: Molecules. 20, 6, p. 10910-10927 18 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
2014
BF3·OEt2-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C-C bond formation
Kotipalli, T., Janreddy, D., Kavala, V., Kuo, C. W., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2014, In: RSC Advances. 4, 88, p. 47833-47840 8 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
FeCl3 catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes
Zanwar, M. R., Kavala, V., Gawande, S. D., Kuo, C. W., Huang, W. C., Kuo, T. S., Huang, H. N., He, C. H. & Yao, C. F., 2014 Feb 21, In: Journal of Organic Chemistry. 79, 4, p. 1842-1849 8 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
Kung, P. J., Tao, Y. C., Hsu, H. C., Chen, W. L., Lin, T. H., Janreddy, D., Yao, C. F., Chang, K. H., Lin, J. Y., Su, M. T., Wu, C. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2014 Oct 16, In: Drug Design, Development and Therapy. 8, p. 1929-1939 11 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Iron/acetic acid mediated intermolecular tandem C-C and C-N bond formation: An easy access to acridinone and quinoline derivatives
Rajawinslin, R. R., Gawande, S. D., Kavala, V., Huang, Y. H., Kuo, C. W., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2014 Jan 1, In: RSC Advances. 4, 71, p. 37806-37811 6 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Iron(III) chloride catalyzed synthesis of highly substituted indolyl-tetrahydroquinoline derivatives by using indolylnitroalkene as dienophiles and its application to the synthesis of indolo-benzonaphthyridine derivatives
Zanwar, M. R., Gawande, S. D., Kavala, V., Kuo, C. W. & Yao, C. F., 2014 Dec 15, In: Advanced Synthesis and Catalysis. 356, 18, p. 3849-3860 12 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Molecular iodine-mediated reaction of 2-(2-phenylethynyl)-Morita-Baylis-Hillman adducts: An easy route to naphthyl ketones and iodo-substituted isochromenes
Janreddy, D., Kavala, V., Kotipalli, T., Rajawinslin, R. R., Kuo, C. W., Huang, W. C. & Yao, C. F., 2014 Nov 7, In: Organic and Biomolecular Chemistry. 12, 41, p. 8247-8256 10 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards triazole linker
Barange, D. K., Kavala, V., Kuo, C. W., Wang, C. C., Rajawinslin, R. R., Donala, J. & Yao, C. F., 2014 Oct 14, In: Tetrahedron. 70, 41, p. 7598-7605 8 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Selectfluor mediated one pot synthesis of cyclohexanone ring fused isoxazole derivatives
Rajawinslin, R. R., Raihan, M. J., Janreddy, D., Kavala, V., Kuo, C. W., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2014 Oct 14, In: Tetrahedron. 70, 41, p. 7505-7510 6 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C-H amidation
Kotipalli, T., Kavala, V., Janreddy, D., Kuo, C. W., Kuo, T. S., Huang, H. N., He, C. H. & Yao, C-F., 2014 Jan 1, In: RSC Advances. 4, 5, p. 2274-2283 10 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Synthesis, structures and electrochemical and photophysical properties of anilido-benzoxazole boron difluoride (ABB) complexes
Meesala, Y., Kavala, V., Chang, H. C., Kuo, T. S., Yao, C-F. & Lee, W-Z., 2014 Nov 24, In: Dalton Transactions. 44, 3, p. 1120-1129 10 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Synthesis of dibenzodiazepinones via tandem copper(I)-catalyzed C-N bond formation
Gawande, S. D., Kavala, V., Zanwar, M. R., Kuo, C. W., Huang, W. C., Kuo, T. S., Huang, H. N., He, C. H. & Yao, C-F., 2014 Aug 11, In: Advanced Synthesis and Catalysis. 356, 11-12, p. 2599-2608 10 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Synthesis of fused isoquinolinone and iminoisoindolinone derivatives via a copper-catalyzed regioselective switching process
Kavala, V., Wang, C. C., Wang, Y. H., Kuo, C. W., Janreddy, D., Huang, W. C., Kuo, T. S., He, C. H., Chen, M. L. & Yao, C-F., 2014 Aug 11, In: Advanced Synthesis and Catalysis. 356, 11-12, p. 2609-2626 18 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems
Lin, C. H., Wu, Y. R., Kung, P. J., Chen, W. L., Lee, L. C., Lin, T. H., Chao, C. Y., Chen, C. M., Chang, K. H., Janreddy, D., Lee-Chen, G. J. & Yao, C. F., 2014 Oct 15, In: ACS Chemical Neuroscience. 5, 10, p. 1063-1074 12 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2013
Copper(I)-catalyzed aerobic oxidative azide-alkene cyclo-addition: An efficient synthesis of substituted 1,2,3-triazoles
Janreddy, D., Kavala, V., Kuo, C. W., Chen, W. C., Ramesh, C., Kotipalli, T., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2013 Jan 1, In: Advanced Synthesis and Catalysis. 355, 14-15, p. 2918-2927 10 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus)