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• 2020

  ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17

  Lin, C. W., Fan, C. H., Chang, Y. C. & Hsieh-Li, H. M., 2020 Nov 1, In: Neuroscience Letters. 738, 135337.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Purkinje Cells
  • Gliosis
  • TATA-Box Binding Protein
  • Cerebellum

• Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

  Liao, J. F., Cheng, Y. F., You, S. T., Kuo, W. C., Huang, C. W., Chiou, J. J., Hsu, C. C., Hsieh-Li, H. M., Wang, S. & Tsai, Y. C., 2020, (Accepted/In press) In: Brain, Behavior, and Immunity. 90, p. 26-46 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lactobacillus plantarum
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Parkinson Disease
  • Gastrointestinal Microbiome
  • Eating

• LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

  Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020, (Accepted/In press) In: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

  Research output: Contribution to journal › Article › peer-review

  • tropomyosin kinase
  • Alzheimer Disease
  • Brain-Derived Neurotrophic Factor
  • Neuronal Plasticity
  • Neurons

• Neuroimaging Spectrum at Pre-, Early, and Late Symptomatic Stages of SCA17 Mice

  Chen, C. C., Yao, N. W., Lin, C. W., Su, W. S., Wu, C. T., Chang, C. & Hsieh-Li, H. M., 2020 Aug 1, In: Cerebellum. 19, 4, p. 487-500 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroimaging
  • Cerebellum
  • Nervous System Heredodegenerative Disorders
  • Atrophy
  • Disease Progression

• Survival Motor Neuron Protein Participates in Mouse Germ Cell Development and Spermatogonium Maintenance

  Chang, W. F., Xu, J., Lin, T. Y., Hsu, J., Hsieh-Li, H. M., Hwu, Y. M., Liu, J. L., Lu, C. H. & Sung, L. Y., 2020 Jan 25, In: International journal of molecular sciences. 21, 3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells
  • Spermatogonia
  • stem cells
  • maintenance
  • mice
  1 Citation (Scopus)

• Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

  Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 Jan 1, (Accepted/In press) In: Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

  Research output: Contribution to journal › Article › peer-review

  • PHA 767491
  • Inflammation
  • Glycogen Synthase Kinase 3
  • tributyl phosphate
  • Proteins
  2 Citations (Scopus)
• 2019

  Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

  Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 Feb 14, In: Psychopharmacology. 236, 2, p. 763-773 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N-(4-hydroxyphenyl)arachidonylamide
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Neuroprotection
  • Hyperglycemia
  6 Citations (Scopus)

• Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

  Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In: Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

  Research output: Contribution to journal › Article › peer-review

  • tropomyosin kinase
  • Low Density Lipoprotein Receptor-Related Protein-1
  • indole
  • Neuroprotection
  • Alzheimer Disease
  4 Citations (Scopus)

• MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ _25-35 -induced anxiety and cognitive deficits in a mouse model

  Huang, H. J., Huang, H. Y. & Hsieh-Li, H. M., 2019 Feb 1, In: CNS Neuroscience and Therapeutics. 25, 2, p. 175-186 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mocetinostat
  • Histone Deacetylase Inhibitors
  • Anxiety
  • Alzheimer Disease
  • 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide
  7 Citations (Scopus)

• Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

  Chiu, Y. J., Hsieh, Y. H., Lin, T. H., Lee, G. C., Hsieh-Li, H. M., Sun, Y. C., Chen, C. M., Chang, K. H. & Lee-Chen, G. J., 2019 May 1, In: Neurochemistry International. 125, p. 175-186 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuronal Outgrowth
  • Alzheimer Disease
  • Inflammation
  • Green Fluorescent Proteins
  • Acetylcholinesterase
  3 Citations (Scopus)

• Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice under Oligomeric Aβ-Induced Stress

  Huang, H. J., Huang, C. Y., Lee, M., Lin, J. Y. & Hsieh-Li, H. M., 2019 Jan 1, In: American Journal of Chinese Medicine. 47, 7, p. 1459-1481 23 p.

  Research output: Contribution to journal › Article › peer-review

  • Pueraria
  • Alzheimer Disease
  • puerarin
  • Anxiety
  • Herbal Medicine
  4 Citations (Scopus)

• Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

  Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019 Jan 1, In: Aging. 11, 3, p. 986-1007 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • Neuroprotection
  • polyglutamine
  • nuclear factor Y
  5 Citations (Scopus)
• 2018

  Administration of Momordica charantia enhances the neuroprotection and reduces the side effects of LiCl in the treatment of Alzheimer’s disease

  Huang, H. J., Chen, S. L., Chang, Y. T., Chyuan, J. H. & Hsieh-Li, H. M., 2018 Dec, In: Nutrients. 10, 12, 1888.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Momordica charantia
  • Lithium Chloride
  • lithium chloride
  • Alzheimer disease
  • Neuroprotection
  7 Citations (Scopus)

• The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

  Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In: NeuroToxicology. 67, p. 259-269 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • indole
  • Neuronal Outgrowth
  • Agglomeration
  11 Citations (Scopus)
• 2017

  Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

  Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 Aug 1, In: Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Thermodynamics
  • Assays
  • Molecular Dynamics Simulation
  • Molecular dynamics
  • Phosphotransferases
  3 Citations (Scopus)

• Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease

  Wang, E., Chiou, Y. Y., Jeng, W. Y., Lin, H. K., Lin, H. H., Chin, H. J., Leo Wang, C. K., Yu, S. S., Tsai, S. C., Chiang, C. Y., Cheng, P. H., Lin, H. J., Jiang, S. T., Chiu, S. T. & Hsieh-Li, H. M., 2017 Feb 1, In: Kidney International. 91, 2, p. 412-422 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipocalin-2
  • Polycystic Kidney Diseases
  • Longevity
  • Cysts
  • Kidney
  5 Citations (Scopus)

• The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

  Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 Jan 1, In: CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • fluorescent protein 583
  • Neuronal Outgrowth
  • Alzheimer Disease
  • Solubility
  10 Citations (Scopus)
• 2016

  Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

  Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh, H. M., Lee, C. M. & Lee-Chen, G. J., 2016 Apr 1, In: CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Melibiose
  • Lactulose
  • Spinocerebellar Ataxias
  • polyglutamine
  • Cell Aggregation
  11 Citations (Scopus)

• Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels

  Chang, Y. C., Lin, C. W., Hsu, C. M., Lee-Chen, G. J., Su, M. T., Ro, L. S., Chen, C. M., Huang, H. J. & Hsieh-Li, H. M., 2016, In: Brain Research. 1639, p. 132-148 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Prodromal Symptoms
  • Granulocyte Colony-Stimulating Factor
  • Autophagy
  • TATA-Box Binding Protein
  8 Citations (Scopus)

• The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

  Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C. H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C. F., Huang, H. J., Lee-Chen, G. J., Lee, M. C. & Hsieh-Li, H. M., 2016 Feb 1, In: Neuropharmacology. 101, p. 309-319 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease
  • Neuronal Outgrowth
  • Synaptophysin
  • Long-Term Potentiation
  • Amyloid Plaques
  10 Citations (Scopus)

• Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

  Huang, D. S., Lin, H. Y., Lee-Chen, G. J., Hsieh-Li, H. M., Wu, C. H. & Lin, J. Y., 2016 Feb 18, In: Drug Design, Development and Therapy. 10, p. 723-731 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Ginkgo biloba extract
  • Animal Models
  • TATA-Box Binding Protein
  • Transgenic Mice
  7 Citations (Scopus)
• 2015

  SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice

  Chang, W. F., Xu, J., Chang, C. C., Yang, S. H., Li, H. Y., Hsieh-Li, H. M., Tsai, M. H., Wu, S. C., Cheng, W. T. K., Liu, J. L. & Sung, L. Y., 2015 May 1, In: Brain Structure and Function. 220, 3, p. 1539-1553 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Embryonic Stem Cells
  • Motor Neurons
  • Cell Differentiation
  • Maintenance
  • Spinal Muscular Atrophy
  8 Citations (Scopus)

• The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

  Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 May 1, In: NeuroToxicology. 48, p. 120-130 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Melibiose
  • Trehalase
  • Neurodegenerative diseases
  • Trehalose
  • Lactulose
  10 Citations (Scopus)

• Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

  Chen, Z. Z., Wang, C. M., Lee, G. C., Hsu, H. C., Wu, T. L., Lin, C. W., Ma, C. K., Lee-Chen, G. J., Huang, H. J. & Hsieh-Li, H. M., 2015 Jan 1, In: Neurochemical Research. 40, 4, p. 800-810 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Gait Ataxia
  • Trehalose
  • Gliosis
  • TATA-Box Binding Protein
  22 Citations (Scopus)
• 2014

  Deactivation of TBP contributes to SCA17 pathogenesis

  Hsu, T. C., Wang, C. K., Yang, C. Y., Lee, L. C., Hsieh-Li, H. M., Ro, L. S., Chen, C. M., Lee-Chen, G. J. & Su, M. T., 2014 Dec 20, In: Human molecular genetics. 23, 25, p. 6878-6893 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • polyglutamine
  • Diptera
  • Retinal Degeneration
  13 Citations (Scopus)

• Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

  Kung, P. J., Tao, Y. C., Hsu, H. C., Chen, W. L., Lin, T. H., Janreddy, D., Yao, C. F., Chang, K. H., Lin, J. Y., Su, M. T., Wu, C. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2014 Oct 16, In: Drug Design, Development and Therapy. 8, p. 1929-1939 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • polyglutamine
  • indole
  • Cell Culture Techniques
  10 Citations (Scopus)

• Multifunctional effects of mangosteen pericarp on cognition in C57BL/6J and triple transgenic alzheimer's mice

  Huang, H. J., Chen, W. L., Hsieh, R. H. & Hsieh-Li, H. M., 2014, In: Evidence-based Complementary and Alternative Medicine. 2014, 813672.

  Research output: Contribution to journal › Article › peer-review

  • Garcinia mangostana
  • Transgenic Mice
  • Cognition
  • Dietary Supplements
  • Diet
  19 Citations (Scopus)
• 2013

  Sodium vanadate combined with l-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy

  Liu, H. C., Ting, C. H., Wen, H. L., Tsai, L. K., Hsieh-Li, H. M., Li, H. & Lin-Chao, S., 2013 Feb 14, In: BMC Medicine. 11, 1, 38.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Muscular Atrophy
  • Vanadates
  • Muscular Atrophy
  • Muscle Weakness
  • Ascorbic Acid
  10 Citations (Scopus)
• 2012

  Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an Intrahippocampal Lipopolysaccharide injection

  Huang, H. J., Chen, Y. H., Liang, K. C., Jheng, Y. S., Jhao, J. J., Su, M. T., Lee-Chen, G. J. & Hsieh-Li, H. M., 2012 Jul 23, In: PloS one. 7, 7, e39656.

  Research output: Contribution to journal › Article › peer-review

  • Exenatide
  • Obese Mice
  • lipopolysaccharides
  • Lipopolysaccharides
  • Cognitive Dysfunction
  45 Citations (Scopus)

• Role of the CCAAT-binding protein NFY in SCA17 pathogenesis

  Lee, L. C., Chen, C. M., Wang, H. C., Hsieh, H. H., Chiu, I. S., Su, M. T., Hsieh-Li, H. M., Wu, C. H., Lee, G. C., Lee-Chen, G. J. & Lin, J. Y., 2012 Apr 17, In: PloS one. 7, 4, e35302.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • nuclear factor Y
  • TATA-Box Binding Protein
  • TATA box
  • pathogenesis
  22 Citations (Scopus)

• The Spinal Muscular Atrophy Disease Protein SMN Is Linked to the Golgi Network

  Ting, C. H., Wen, H. L., Liu, H. C., Hsieh-Li, H. M., Li, H. & Lin-Chao, S., 2012 Dec 17, In: PloS one. 7, 12, e51826.

  Research output: Contribution to journal › Article › peer-review

  • muscular atrophy
  • Spinal Muscular Atrophy
  • motor neurons
  • Muscular Diseases
  • Motor Neurons
  32 Citations (Scopus)

• Yang-Dan-Tang, identified from 15 Chinese herbal formulae, inhibits human lung cancer cell proliferation via cell cycle arrest

  Wang, T. C., Fang, C. N., Shen, C. C., Wei, H. Y., Weng, Y. P., Lin, J. Y., Hsieh-Li, H. M. & Lee, C. Y., 2012, In: Evidence-based Complementary and Alternative Medicine. 2012, 276032.

  Research output: Contribution to journal › Article › peer-review

  • Cell Cycle Checkpoints
  • Lung Neoplasms
  • A549 Cells
  • Cell Proliferation
  • Non-Small Cell Lung Carcinoma
  4 Citations (Scopus)
• 2011

  Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models

  Lin, Y. T., Chern, Y., Shen, C. K. J., Wen, H. L., Chang, Y. C., Li, H., Cheng, T. H. & Hsieh-Li, H. M., 2011, In: PloS one. 6, 8, e22924.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • disease models
  • mesenchymal stromal cells
  • Huntington Disease
  • bone marrow
  71 Citations (Scopus)

• Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice

  Huang, H. J., Liang, K. C., Ke, H. C., Chang, Y. Y. & Hsieh-Li, H. M., 2011 Jan 31, In: Brain Research. 1371, p. 150-160 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Social Isolation
  • Spatial Memory
  • Short-Term Memory
  • Transgenic Mice
  • Hippocampus
  52 Citations (Scopus)

• Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12)

  Wang, Y. C., Lee, C. M., Lee, L. C., Tung, L. C., Hsieh-Li, H. M., Lee-Chen, G. J. & Su, M. T., 2011 Jun 17, In: Journal of Biological Chemistry. 286, 24, p. 21742-21754 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 12
  • Oxidative stress
  • Diptera
  • Mitochondria
  • Drosophila
  41 Citations (Scopus)

• Neuroprotective effects of granulocyte-colony stimulating factor in a novel transgenic mouse model of SCA17

  Chang, Y. C., Lin, C. Y., Hsu, C. M., Lin, H. C., Chen, Y. H., Lee-Chen, G. J., Su, M. T., Ro, L. S., Chen, C. M. & Hsieh-Li, H. M., 2011 Jul 1, In: Journal of Neurochemistry. 118, 2, p. 288-303 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • Granulocyte Colony-Stimulating Factor
  • Neuroprotective Agents
  • Transgenic Mice
  33 Citations (Scopus)

• Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise

  Ke, H. C., Huang, H. J., Liang, K. C. & Hsieh-Li, H. M., 2011 Jul 27, In: Brain Research. 1403, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Transgenic Mice
  • Cognition
  • Serotonergic Neurons
  • Raphe Nuclei
  • Acclimatization
  53 Citations (Scopus)