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  • Ching-Fa Yao
2020

Copper-catalysed synthesis of 3-hydroxyisoindolin-1-ones from benzylcyanide 2-iodobenzamides

Kavala, V., Wang, C. Y., Wang, C. C., Patil, P. B., Fang, C. C., Kuo, C. W. & Yao, C. F., 2020 Jan 1, In : Organic and Biomolecular Chemistry. 18, 5, p. 988-998 11 p.

Research output: Contribution to journalArticle

Synthesis of Pyrido[2,3-b]indoles via Brønsted-Acid-Promoted Decarboxylative Annulation of 3-Bromopropenals and Ethyl 2-Amino-1H-indole-3-carboxylates

Yang, T. H., Kavala, V., Kuo, C. W. & Yao, C. F., 2020 Jul 1, In : Asian Journal of Organic Chemistry. 9, 7, p. 1053-1058 6 p.

Research output: Contribution to journalArticle

2019

A Synthetic Strategy for the Construction of Functionalized Triphenylene Frameworks via Palladium Catalyzed Intramolecular Annulation/Decyanogenative C-H Bond Alkenylation

Ichake, S. S., Villuri, B. K., Reddy, S. R., Kavala, V. & Yao, C. F., 2019 Jan 1, In : Organic Letters. 21, 7, p. 2256-2260 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In : Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Microwave-Assisted Ruthenium(II)-Catalyzed C−H/N−O Activation of N-Methoxybenzamides with Alkynylsulfane

Sarathkumar, S., Kavala, V. & Yao, C. F., 2019 Oct 1, In : Asian Journal of Organic Chemistry. 8, 10, p. 1830-1833 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

Wei, P. C., Lee-Chen, G. J., Chen, C. M., Wu, Y. R., Chen, Y. J., Lin, J. L., Lo, Y. S., Yao, C. F. & Chang, K. H., 2019, In : Oxidative medicine and cellular longevity. 2019, 5074367.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Synthesis of Polysubstituted Cyclopentene and Cyclopenta[ b]carbazole Analogues from Unsymmetrical 4-Arylidene-3,6-diarylhex-2-en-5-ynal and Indole Derivatives via an Iodine Mediated Electrocyclization Reaction

Bandi, V., Kavala, V., Konala, A., Hsu, C. H., Villuri, B. K., Reddy, S. R., Lin, L., Kuo, C. W. & Yao, C. F., 2019 Mar 15, In : Journal of Organic Chemistry. 84, 6, p. 3036-3044 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

A triazole-conjugated benzoxazone induces reactive oxygen species and promotes autophagic apoptosis in human lung cancer cells

Hsieh, C. H., Wang, J. P., Chiu, C. C., Liu, C. Y., Yao, C. F. & Fang, K., 2018 Jan 1, In : Apoptosis. 23, 1

Research output: Contribution to journalArticle

6 Citations (Scopus)

Copper-Catalyzed Cascade Synthesis of 2-Aryl-3-cyanobenzofuran and Dibenzo[ b, f]oxepine-10-carbonitrile Derivatives

Villuri, B. K., Ichake, S. S., Reddy, S. R., Kavala, V., Bandi, V., Kuo, C. W. & Yao, C. F., 2018 Sep 7, In : Journal of Organic Chemistry. 83, 17, p. 10241-10247 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Kavala, V., Yang, Z., Konala, A., Yang, T. H., Kuo, C. W., Ruan, J. Y. & Yao, C. F., 2018 Mar 14, In : European Journal of Organic Chemistry. 2018, 10, p. 1241-1247 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In : NeuroToxicology. 67, p. 259-269 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

A Copper-Catalyzed Cascade Approach for the Synthesis of Dibenzo[b,f]1,8-naphthyridine Derivatives

Villuri, B. K., Konala, A., Kavala, V., Kotipalli, T., Kuo, C. W. & Yao, C. F., 2017 Sep 18, In : Advanced Synthesis and Catalysis. 359, 18, p. 3142-3153 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres

Ni, Y. L., Hsieh, C. H., Kim, S. H., Wang, J. P., Su, C. L., Yao, C. F. & Fang, K., 2017 Oct 1, In : Apoptosis. 22, 10, p. 1235-1245 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Palladium-catalyzed tandem C-H functionalization/cyclization strategy for the synthesis of 5-hydroxybenzofuran derivatives

Ichake, S. S., Konala, A., Kavala, V., Kuo, C. W. & Yao, C. F., 2017 Jan 1, In : Organic Letters. 19, 1, p. 54-57 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Regioselective switching approach for the synthesis of α and δ carboline derivatives

Yang, T. H., Kuo, C. W., Kavala, V., Konala, A., Huang, C. Y. & Yao, C. F., 2017 Jan 1, In : Chemical Communications. 53, 10, p. 1676-1679 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2-Iodobenzamide Derivatives and 2-Iodobenzylcyanides

Kavala, V., Yang, Z., Konala, A., Huang, C. Y., Kuo, C. W. & Yao, C. F., 2017 Jul 21, In : Journal of Organic Chemistry. 82, 14, p. 7280-7286 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis of Biologically Active Indenoisoquinoline Derivatives via a One-Pot Copper(II)-Catalyzed Tandem Reaction

Huang, C. Y., Kavala, V., Kuo, C. W., Konala, A., Yang, T. H. & Yao, C. F., 2017 Feb 17, In : Journal of Organic Chemistry. 82, 4, p. 1961-1968 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and their application in the synthesis of trisubstituted pyridines

Bandi, V., Kavala, V., Hsu, C. H., Konala, A., Villuri, B. K., Kotipalli, T., Kuo, C. W. & Yao, C. F., 2017 Jan 1, In : RSC Advances. 7, 74, p. 46704-46712 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 Jan 1, In : CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction

Su, C. L., Tseng, C. L., Ramesh, C., Liu, H. S., Huang, C. Y. F. & Yao, C. F., 2017 Jan 1, In : European Journal of Medicinal Chemistry. 132, p. 90-107 18 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

An indolylquinoline derivative activates DNA damage response and apoptosis in human hepatocellular carcinoma cells

Liu, C. Y., Hsieh, C. H., Kim, S. H., Wang, J. P., Ni, Y. L., Su, C. L., Yao, C. F. & Fang, K., 2016 Dec, In : International Journal of Oncology. 49, 6, p. 2431-2441 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Atriazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Hsieh, C. H., Lee, L. C., Leong, W. Y., Yang, T. C., Yao, C. F. & Fang, K., 2016 Sep 14, In : Drug Design, Development and Therapy. 10, p. 2947-2957 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

N-Bromosuccinimide-Mediated Thiocyanation of Cyclohexene-Fused Isoxazoline N-Oxides

Ichake, S. S., Rajawinslin, R. R., Kavala, V., Villuri, B. K., Yang, H. T., Kuo, C. W. & Yao, C-F., 2016 Mar 1, In : Asian Journal of Organic Chemistry. 5, 3, p. 343-352 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4-Oxadiazole/1,3,4-Oxadiazoline and 1,2,4-Triazole Derivatives from N-Substituted Hydrazides

Kotipalli, T., Kavala, V., Konala, A., Janreddy, D., Kuo, C. W. & Yao, C. F., 2016 Jan 1, In : Advanced Synthesis and Catalysis. 358, 16, p. 2652-2660 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Syntheses of 2-Benzylbenzofuran Derivatives and 2-Aryl-nitrochroman Derivatives from Nitroalkene Precursors

Huang, C. Y., Kuo, C. W., Kavala, V. & Yao, C. F., 2016 May 1, In : European Journal of Organic Chemistry. 2016, 15, p. 2720-2734 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Synthesis of 2,3-Disubstituted Quinazolinone Derivatives through Copper Catalyzed C-H Amidation Reactions

Kotipalli, T., Kavala, V., Janreddy, D., Bandi, V., Kuo, C. W. & Yao, C. F., 2016 Feb 1, In : European Journal of Organic Chemistry. 2016, 6, p. 1182-1193 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Synthesis of 3-arylindole derivatives from nitroalkane precursors

Huang, C. Y., Kuo, C. W., Konala, A., Yang, T. H., Lin, L., Chen, Y. W., Kavala, V. & Yao, C. F., 2016 Jan 1, In : RSC Advances. 6, 98, p. 96049-96056 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis of benzo[: A] carbazole derivatives from 3-ethylindoles by exploiting the dual character of benzoquinone as an oxidizing agent and dienophile

Kuo, C. W., Konala, A., Lin, L., Chiang, T. T., Huang, C. Y., Yang, T. H., Kavala, V. & Yao, C. F., 2016 Jan 1, In : Chemical Communications. 52, 50, p. 7870-7873 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Synthesis of spiro isoindolinone-indolines and 1,2-disubstituted indoles from 2-iodobenzamide derivatives

Villuri, B. K., Kotipalli, T., Kavala, V., Ichake, S. S., Bandi, V., Kuo, C. W. & Yao, C. F., 2016 Jan 1, In : RSC Advances. 6, 78, p. 74845-74858 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C. H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C. F., Huang, H. J., Lee-Chen, G. J., Lee, M. C. & Hsieh-Li, H. M., 2016 Feb 1, In : Neuropharmacology. 101, p. 309-319 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions

Liu, C. Y., Wu, P. T., Wang, J. P., Fan, P. W., Hsieh, C. H., Su, C. L., Chiu, C. C., Yao, C. F. & Fang, K., 2015 Nov 30, In : Apoptosis. 20, 11, p. 1471-1482 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo[b,j][1,7]phenanthroline derivatives via intramolecular reductive cyclization

Rajawinslin, R. R., Ichake, S. S., Kavala, V., Gawande, S. D., Huang, Y. H., Kuo, C. W. & Yao, C. F., 2015 Jan 1, In : RSC Advances. 5, 64, p. 52141-52153 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

One-pot synthesis of 2-arylquinazolines and tetracyclic isoindolo[1,2-a]quinazolines via cyanation followed by rearrangement of ortho-substituted 2-halo-N-arylbenzamides

Gawande, S. D., Zanwar, M. R., Kavala, V., Kuo, C. W., Rajawinslin, R. R. & Yao, C-F., 2015 Dec 4, In : Advanced Synthesis and Catalysis. 357, 1, p. 168-176 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

Chen, W. C., Lin, C. C., Kavala, V., Kuo, C. W., Huang, C. Y. & Yao, C. F., 2015 Dec 15, In : Molecules. 20, 12, p. 22499-22519 21 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition

Chen, W. C., Kavala, V., Shih, Y. H., Wang, Y. H., Kuo, C. W., Yang, T. H., Huang, C. Y., Chiu, H. H. & Yao, C. F., 2015 Jun 1, In : Molecules. 20, 6, p. 10910-10927 18 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

BF3·OEt2-mediated one pot synthesis of 10-indolyldibenzo[b,f]azepine derivatives via tandem ring expansion and C-C bond formation

Kotipalli, T., Janreddy, D., Kavala, V., Kuo, C. W., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2014, In : RSC Advances. 4, 88, p. 47833-47840 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

FeCl3 catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes

Zanwar, M. R., Kavala, V., Gawande, S. D., Kuo, C. W., Huang, W. C., Kuo, T. S., Huang, H. N., He, C. H. & Yao, C. F., 2014 Feb 21, In : Journal of Organic Chemistry. 79, 4, p. 1842-1849 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Kung, P. J., Tao, Y. C., Hsu, H. C., Chen, W. L., Lin, T. H., Janreddy, D., Yao, C. F., Chang, K. H., Lin, J. Y., Su, M. T., Wu, C. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2014 Oct 16, In : Drug Design, Development and Therapy. 8, p. 1929-1939 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Iron/acetic acid mediated intermolecular tandem C-C and C-N bond formation: An easy access to acridinone and quinoline derivatives

Rajawinslin, R. R., Gawande, S. D., Kavala, V., Huang, Y. H., Kuo, C. W., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2014 Jan 1, In : RSC Advances. 4, 71, p. 37806-37811 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
9 Citations (Scopus)

Molecular iodine-mediated reaction of 2-(2-phenylethynyl)-Morita-Baylis-Hillman adducts: An easy route to naphthyl ketones and iodo-substituted isochromenes

Janreddy, D., Kavala, V., Kotipalli, T., Rajawinslin, R. R., Kuo, C. W., Huang, W. C. & Yao, C. F., 2014 Nov 7, In : Organic and Biomolecular Chemistry. 12, 41, p. 8247-8256 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Regioselective synthesis of thiophene fused sultam derivatives via iodocyclization approach and their application towards triazole linker

Barange, D. K., Kavala, V., Kuo, C. W., Wang, C. C., Rajawinslin, R. R., Donala, J. & Yao, C. F., 2014 Oct 14, In : Tetrahedron. 70, 41, p. 7598-7605 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Selectfluor mediated one pot synthesis of cyclohexanone ring fused isoxazole derivatives

Rajawinslin, R. R., Raihan, M. J., Janreddy, D., Kavala, V., Kuo, C. W., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2014 Oct 14, In : Tetrahedron. 70, 41, p. 7505-7510 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C-H amidation

Kotipalli, T., Kavala, V., Janreddy, D., Kuo, C. W., Kuo, T. S., Huang, H. N., He, C. H. & Yao, C-F., 2014 Jan 1, In : RSC Advances. 4, 5, p. 2274-2283 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis, structures and electrochemical and photophysical properties of anilido-benzoxazole boron difluoride (ABB) complexes

Meesala, Y., Kavala, V., Chang, H. C., Kuo, T. S., Yao, C-F. & Lee, W-Z., 2014 Nov 24, In : Dalton Transactions. 44, 3, p. 1120-1129 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Synthesis of dibenzodiazepinones via tandem copper(I)-catalyzed C-N bond formation

Gawande, S. D., Kavala, V., Zanwar, M. R., Kuo, C. W., Huang, W. C., Kuo, T. S., Huang, H. N., He, C. H. & Yao, C-F., 2014 Aug 11, In : Advanced Synthesis and Catalysis. 356, 11-12, p. 2599-2608 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synthesis of fused isoquinolinone and iminoisoindolinone derivatives via a copper-catalyzed regioselective switching process

Kavala, V., Wang, C. C., Wang, Y. H., Kuo, C. W., Janreddy, D., Huang, W. C., Kuo, T. S., He, C. H., Chen, M. L. & Yao, C-F., 2014 Aug 11, In : Advanced Synthesis and Catalysis. 356, 11-12, p. 2609-2626 18 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems

Lin, C. H., Wu, Y. R., Kung, P. J., Chen, W. L., Lee, L. C., Lin, T. H., Chao, C. Y., Chen, C. M., Chang, K. H., Janreddy, D., Lee-Chen, G. J. & Yao, C. F., 2014 Oct 15, In : ACS Chemical Neuroscience. 5, 10, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013

Copper(I)-catalyzed aerobic oxidative azide-alkene cyclo-addition: An efficient synthesis of substituted 1,2,3-triazoles

Janreddy, D., Kavala, V., Kuo, C. W., Chen, W. C., Ramesh, C., Kotipalli, T., Kuo, T. S., Chen, M. L., He, C. H. & Yao, C. F., 2013 Jan 1, In : Advanced Synthesis and Catalysis. 355, 14-15, p. 2918-2927 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Halonium ion mediated synthesis of 2-halomethylene-3-oxoketoxime derivatives from isoxazoline N -oxides

Raihan, M. J., Rajawinslin, R. R., Kavala, V., Kuo, C. W., Kuo, T. S., He, C. H., Huang, H. N. & Yao, C. F., 2013 Sep 6, In : Journal of Organic Chemistry. 78, 17, p. 8872-8879 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)