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• 2020

  Association of SOD2 p.V16A polymorphism with Parkinson's disease: A meta-analysis in Han Chinese

  Wu, Y. R., Chang, K. H., Chao, C. Y., Lin, C. H., Chen, Y. C., Liu, T. W., Lee-Chen, G. J. & Chen, C. M., 2020, (Accepted/In press) In: Journal of the Formosan Medical Association. 120, 1, p. 501-507 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • superoxide dismutase 2
  • Parkinson Disease
  • Meta-Analysis
  • Genotype
  • Complementary DNA

• Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer’s disease cell and mouse models

  Lin, T. H., Chiu, Y. J., Lin, C. H., Lin, C. Y., Chao, C. Y., Chen, Y. C., Yang, S. M., Lin, W., Mei Hsieh-Li, H., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 Jul 1, In: Aging Cell. 19, 7, ACEL13169.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fluorescent protein 583
  • licochalcone A
  • Alzheimer Disease
  • Neuronal Outgrowth
  • Reactive Oxygen Species
  2 Citations (Scopus)

• Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease

  Chiang, H. L., Chen, C. M., Chen, Y. C., Chao, C. Y., Wu, Y. R. & Lee-Chen, G. J., 2020, In: Parkinson's Disease. 2020, 9582317.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parkinson Disease
  • Iron Regulatory Protein 2
  • Iron
  • Dioxygenases
  • Oxygen

• Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy

  Lin, C. H., Wei, P. C., Chen, C. M., Huang, Y. T., Lin, J. L., Lo, Y. S., Lin, J. L., Lin, C. Y., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2020 Jul 24, In: Frontiers in Aging Neuroscience. 12, 226.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melibiose
  • Lactulose
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Autophagy
  • Parkinson Disease

• Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability

  Chen, C. M., Lin, C. H., Wu, Y. R., Yen, C. Y., Huang, Y. T., Lin, J. L., Lin, C. Y., Chen, W. L., Chao, C. Y., Lee-Chen, G. J., Su, M. T. & Chang, K. H., 2020 May 16, In: Cells. 9, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melibiose
  • Synucleins
  • Lactulose
  • Autophagy
  • Up-Regulation
  2 Citations (Scopus)

• LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer’s disease

  Fan, C. H., Lin, C. W., Huang, H. J., Lee-Chen, G. J., Sun, Y. C., Lin, W., Chen, C. M., Chang, K. H., Su, M. T. & Hsieh-Li, H. M., 2020, (Accepted/In press) In: Psychopharmacology. 237, 10, p. 3173-3190 18 p.

  Research output: Contribution to journal › Article › peer-review

  • tropomyosin kinase
  • Alzheimer Disease
  • Brain-Derived Neurotrophic Factor
  • Neuronal Plasticity
  • Neurons

• New Synthetic 3-Benzoyl-5-Hydroxy-2 H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK α in SCA17 Cell Models

  Chen, C. M., Chen, W. L., Yang, S. T., Lin, T. H., Yang, S. M., Lin, W., Chao, C. Y., Wu, Y. R., Chang, K. H. & Lee-Chen, G. J., 2020, In: Oxidative medicine and cellular longevity. 2020, p. 3129497 3129497.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spinocerebellar Ataxia 17
  • licochalcone A
  • polyglutamine
  • AMP-Activated Protein Kinases
  • Neuronal Outgrowth

• Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

  Chiu, Y. J., Lin, S. A., Chen, W. L., Lin, T. H., Lin, C. H., Yao, C. F., Lin, W., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Chen, C. M., 2020 Dec, In: Aging. 12, 23, p. 23619-23646 28 p.

  Research output: Contribution to journal › Article › peer-review

  • polyglutamine
  • N-(4-hydroxyphenyl)arachidonylamide
  • Microglia
  • Interleukin-1
  • 4-aminophenol

• Rare VPS35 A320V variant in Taiwanese Parkinson’s disease indicates disrupted CI-MPR sorting and impaired mitochondrial morphology

  Wu, Y. R., Lin, C. H., Chao, C. Y., Chang, C. W., Chen, C. M. & Lee-Chen, G. J., 2020 Nov, In: Brain Sciences. 10, 11, p. 1-12 12 p., 0783.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • IGF Type 2 Receptor
  • Protein Transport
  • Cations
  • Parkinson Disease
  • HEK293 Cells

• Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

  Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 Jan 1, (Accepted/In press) In: Journal of Molecular Neuroscience. 70, 7, p. 1140-1152 13 p.

  Research output: Contribution to journal › Article › peer-review

  • PHA 767491
  • Inflammation
  • Glycogen Synthase Kinase 3
  • tributyl phosphate
  • Proteins
  2 Citations (Scopus)
• 2019

  Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

  Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 Feb 14, In: Psychopharmacology. 236, 2, p. 763-773 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N-(4-hydroxyphenyl)arachidonylamide
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Neuroprotection
  • Hyperglycemia
  6 Citations (Scopus)

• Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

  Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In: Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

  Research output: Contribution to journal › Article › peer-review

  • tropomyosin kinase
  • Low Density Lipoprotein Receptor-Related Protein-1
  • indole
  • Neuroprotection
  • Alzheimer Disease
  4 Citations (Scopus)

• Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery

  Lin, C. J., Lin, C. Y., Lin, Y. T., Huang, C. Y., Wei, K. C., Chen, J. C., Lee-Chen, G. J. & Liu, H. L., 2019 Sep 10, In: Biochemical and Biophysical Research Communications. 517, 1, p. 77-83 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Microbubbles
  • Genes
  • Ultrasonics
  • Brain

• Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

  Wei, P. C., Lee-Chen, G. J., Chen, C. M., Wu, Y. R., Chen, Y. J., Lin, J. L., Lo, Y. S., Yao, C. F. & Chang, K. H., 2019, In: Oxidative medicine and cellular longevity. 2019, 5074367.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • indole
  • Neuroprotection
  • Dopaminergic Neurons
  • Parkinson Disease
  • Derivatives
  8 Citations (Scopus)

• Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

  Chiu, Y. J., Hsieh, Y. H., Lin, T. H., Lee, G. C., Hsieh-Li, H. M., Sun, Y. C., Chen, C. M., Chang, K. H. & Lee-Chen, G. J., 2019 May 1, In: Neurochemistry International. 125, p. 175-186 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuronal Outgrowth
  • Alzheimer Disease
  • Inflammation
  • Green Fluorescent Proteins
  • Acetylcholinesterase
  3 Citations (Scopus)

• Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons

  Chen, I. C., Chang, K. H., Chen, Y. J., Chen, Y. C., Lee-Chen, G. J. & Chen, C. M., 2019 Jan 1, In: Oxidative Medicine and Cellular Longevity. 2019, 8130481.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pueraria
  • Machado-Joseph Disease
  • Cytotoxicity
  • Stem cells
  • daidzein

• Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

  Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019 Jan 1, In: Aging. 11, 3, p. 986-1007 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • Neuroprotection
  • polyglutamine
  • nuclear factor Y
  5 Citations (Scopus)

• Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3

  Chen, I. C., Chang, C. N., Chen, W. L., Lin, T. H., Chao, C. Y., Lin, C. H., Lin, H. Y., Cheng, M. L., Chiang, M. C., Lin, J. Y., Wu, Y. R., Lee-Chen, G. J. & Chen, C. M., 2019 Jan 1, In: American Journal of Chinese Medicine. 47, 1, p. 63-95 33 p.

  Research output: Contribution to journal › Article › peer-review

  • Machado-Joseph Disease
  • polyglutamine
  • Chinese Traditional Medicine
  • Proteasome Endopeptidase Complex
  • Ubiquitin
  5 Citations (Scopus)
• 2018

  Chinese Herbal Medicine Glycyrrhiza inflata Reduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

  Chiu, Y. J., Lee, C. M., Lin, T. H., Lin, H. Y., Lee, S. Y., Mesri, M., Chang, K. H., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2018 Jan 1, In: American Journal of Chinese Medicine. 46, 7, p. 1535-1549 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycyrrhiza
  • Herbal Medicine
  • Neuroprotection
  • Inflammation
  • licochalcone A
  2 Citations (Scopus)

• Formulated Chinese medicine shaoyao gancao tang reduces tau aggregation and exerts neuroprotection through anti-oxidation and anti-inflammation

  Chen, I. C., Lin, T. H., Hsieh, Y. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Lee, M. C., Lee-Chen, G. J. & Chen, C. M., 2018 Jan 1, In: Oxidative Medicine and Cellular Longevity. 2018, 9595741.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia
  • Glycyrrhiza uralensis
  • Neuroprotection
  • Medicine
  • Oxidation
  12 Citations (Scopus)

• Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders

  Chang, K. H., Lee, G. C., Huang, C. C., Kuo, H. C., Chen, C. M., Hsiao, Y. C., Hsu, H. C., Hsu, K. J., Lin, C. H., Chang, C. W., Lee-Chen, G. J. & Wu, Y. R., 2018 Jun, In: Parkinsonism and Related Disorders. 51, p. 61-66 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Parkinsonian Disorders
  • Progranulins
  • Mutation
  • Frontotemporal Dementia
  • Protein Stability
  2 Citations (Scopus)

• Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

  Chang, K. H., Lee-Chen, G. J., Huang, C. C., Lin, J. L., Chen, Y. J., Wei, P. C., Lo, Y. S., Yao, C. F., Kuo, M. W. & Chen, C. M., 2018 Jan 1, (Accepted/In press) In: Molecular Neurobiology. 56, 6, p. 3972-3983 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells
  • Alzheimer Disease
  • Mutation
  • Neurons
  • Caspase 1
  14 Citations (Scopus)

• Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection

  Lee, S. Y., Chiu, Y. J., Yang, S. M., Chen, C. M., Huang, C. C., Lee-Chen, G. J., Lin, W. & Chang, K. H., 2018 Dec, In: CNS Neuroscience and Therapeutics. 24, 12, p. 1286-1298 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Chalcone
  • coumarin
  • Neuroprotection
  • Alzheimer Disease
  • Reactive Oxygen Species
  7 Citations (Scopus)

• The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

  Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In: NeuroToxicology. 67, p. 259-269 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • indole
  • Neuronal Outgrowth
  • Agglomeration
  11 Citations (Scopus)
• 2017

  Functional properties of LRRK2 mutations in Taiwanese Parkinson disease

  Chang, K. H., Chen, C. M., Lin, C. H., Chang, W. T., Jiang, P. R., Hsiao, Y. C., Wu, Y. R. & Lee-Chen, G. J., 2017 Mar 1, In: Journal of the Formosan Medical Association. 116, 3, p. 197-204 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucine
  • Parkinson Disease
  • Phosphotransferases
  • Mutation
  • Guanosine Triphosphate
  1 Citation (Scopus)

• Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

  Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 Aug 1, In: Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Thermodynamics
  • Assays
  • Molecular Dynamics Simulation
  • Molecular dynamics
  • Phosphotransferases
  3 Citations (Scopus)

• The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

  Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee-Chen, G. J., Hsieh-Li, H. M. & Yao, C. F., 2017 Jan 1, In: CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • fluorescent protein 583
  • Neuronal Outgrowth
  • Alzheimer Disease
  • Solubility
  10 Citations (Scopus)
• 2016

  Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan

  Chen, C. M., Chen, Y. C., Chiang, M. C., Fung, H. C., Chang, K. H., Lee-Chen, G. J. & Wu, Y. R., 2016 Mar 1, In: Neurobiology of Aging. 39, p. 221.e1-221.e5

  Research output: Contribution to journal › Article › peer-review

  • Taiwan
  • Parkinson Disease
  • Genome-Wide Association Study
  • Odds Ratio
  • Genetic Loci
  9 Citations (Scopus)

• Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

  Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G. C. & Lee-Chen, G. J., 2016 Jun 30, In: European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3
  • fluorescent protein 583
  • Enzyme Assays
  • Alzheimer Disease
  • Phosphotransferases
  16 Citations (Scopus)

• Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease

  Chang, K. H., Lee-Chen, G. J., Wu, Y. R., Chen, Y. J., Lin, J. L., Li, M., Chen, I. C., Lo, Y. S., Wu, H. C. & Chen, C. M., 2016 Mar 1, In: Parkinsonism and Related Disorders. 24, p. 81-88 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Induced Pluripotent Stem Cells
  • Proteasome Endopeptidase Complex
  • Parkinson Disease
  • Synucleins
  • Neurons
  19 Citations (Scopus)

• Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP⁺ damage via inducing FBXO7 expression

  Chen, C. M., Chen, I. C., Chen, Y. L., Lin, T. H., Chen, W. L., Chao, C. Y., Wu, Y. R., Lu, Y. T., Lee, C. Y., Chien, H. C., Chen, T. S., Lee-Chen, G. J. & Lee, C. M., 2016 Nov 15, In: Phytomedicine. 23, 12, p. 1422-1433 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Oenanthe
  • Sorghum
  • F-Box Proteins
  • Medicinal Plants
  • TNF Receptor-Associated Factor 2
  1 Citation (Scopus)

• Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

  Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh, H. M., Lee, C. M. & Lee-Chen, G. J., 2016 Apr 1, In: CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Melibiose
  • Lactulose
  • Spinocerebellar Ataxias
  • polyglutamine
  • Cell Aggregation
  11 Citations (Scopus)

• Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels

  Chang, Y. C., Lin, C. W., Hsu, C. M., Lee-Chen, G. J., Su, M. T., Ro, L. S., Chen, C. M., Huang, H. J. & Hsieh-Li, H. M., 2016, In: Brain Research. 1639, p. 132-148 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Prodromal Symptoms
  • Granulocyte Colony-Stimulating Factor
  • Autophagy
  • TATA-Box Binding Protein
  8 Citations (Scopus)

• The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

  Chang, K. H., Chen, I. C., Lin, H. Y., Chen, H. C., Lin, C. H., Lin, T. H., Weng, Y. T., Chao, C. Y., Wu, Y. R., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2016 Feb 29, In: Drug Design, Development and Therapy. 10, p. 885-896 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fluorescent protein 583
  • Glycyrrhiza
  • Unfolded Protein Response
  • Tauopathies
  • Alzheimer Disease
  13 Citations (Scopus)

• The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

  Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C. H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C. F., Huang, H. J., Lee-Chen, G. J., Lee, M. C. & Hsieh-Li, H. M., 2016 Feb 1, In: Neuropharmacology. 101, p. 309-319 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease
  • Neuronal Outgrowth
  • Synaptophysin
  • Long-Term Potentiation
  • Amyloid Plaques
  10 Citations (Scopus)

• Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17

  Huang, D. S., Lin, H. Y., Lee-Chen, G. J., Hsieh-Li, H. M., Wu, C. H. & Lin, J. Y., 2016 Feb 18, In: Drug Design, Development and Therapy. 10, p. 723-731 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Ginkgo biloba extract
  • Animal Models
  • TATA-Box Binding Protein
  • Transgenic Mice
  7 Citations (Scopus)
• 2015

  Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population

  Chen, Y. C., Huang, C. J., Chen, P., Wu, Y. R., Shie, S. S., Chen, S. T., Lee-Chen, G. J. & Chen, C. M., 2015 Sep 1, In: Biomedical Journal. 38, 5, p. 433-438 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Taiwan
  • Protein Kinase C
  • Lacunar Stroke
  • Stroke
  • Odds Ratio
  3 Citations (Scopus)

• STK39, but Not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated with Han-Chinese Parkinson's disease in Taiwan

  Chang, K. H., Wu, Y. R., Chen, Y. C., Fung, H. C., Lee-Chen, G. J. & Chen, C. M., 2015 Jan 1, In: Medicine (United States). 94, 41, e1690.

  Research output: Contribution to journal › Article › peer-review

  • signal peptide peptidase
  • HLA-DQB1 antigen
  • Protein-Serine-Threonine Kinases
  • Taiwan
  • Parkinson Disease
  9 Citations (Scopus)

• The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

  Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 May 1, In: NeuroToxicology. 48, p. 120-130 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Melibiose
  • Trehalase
  • Neurodegenerative diseases
  • Trehalose
  • Lactulose
  10 Citations (Scopus)

• Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

  Chen, Z. Z., Wang, C. M., Lee, G. C., Hsu, H. C., Wu, T. L., Lin, C. W., Ma, C. K., Lee-Chen, G. J., Huang, H. J. & Hsieh-Li, H. M., 2015 Jan 1, In: Neurochemical Research. 40, 4, p. 800-810 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • Gait Ataxia
  • Trehalose
  • Gliosis
  • TATA-Box Binding Protein
  22 Citations (Scopus)
• 2014

  Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3

  Chang, K. H., Chen, W. L., Wu, Y. R., Lin, T. H., Wu, Y. C., Chao, C. Y., Lin, J. Y., Lee, L. C., Chen, Y. C., Lee-Chen, G. J. & Chen, C. M., 2014 Jun 1, In: Neuropharmacology. 81, p. 166-175 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gardenia
  • Machado-Joseph Disease
  • crocin
  • polyglutamine
  • geniposide
  19 Citations (Scopus)

• Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3

  Chen, C. M., Weng, Y. T., Chen, W. L., Lin, T. H., Chao, C. Y., Lin, C. H., Chen, I. C., Lee, L. C., Lin, H. Y., Wu, Y. R., Chen, Y. C., Chang, K. H., Tang, H. Y., Cheng, M. L., Lee-Chen, G. J. & Lin, J. Y., 2014 Jun, In: Free Radical Biology and Medicine. 71, p. 339-350 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Machado-Joseph Disease
  • licochalcone A
  • Glycyrrhiza
  • polyglutamine
  • Oxidative stress
  22 Citations (Scopus)

• Deactivation of TBP contributes to SCA17 pathogenesis

  Hsu, T. C., Wang, C. K., Yang, C. Y., Lee, L. C., Hsieh-Li, H. M., Ro, L. S., Chen, C. M., Lee-Chen, G. J. & Su, M. T., 2014 Dec 20, In: Human molecular genetics. 23, 25, p. 6878-6893 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • polyglutamine
  • Diptera
  • Retinal Degeneration
  13 Citations (Scopus)

• Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17

  Lee, L. C., Weng, Y. T., Wu, Y. R., Soong, B. W., Tseng, Y-C., Chen, C. M. & Lee, G-J., 2014 Jan 1, In: Journal of Neural Transmission. 121, 6, p. 601-610 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • polyglutamine
  • Endoplasmic Reticulum Stress
  • Down-Regulation
  • genipin
  11 Citations (Scopus)

• FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease

  Chen, C. M., Chen, I. G., Huang, Y. C., Juan, H. F., Chen, Y. L., Chen, Y. C., Lin, C. H., Lee, L. C., Lee, C. M., Lee-Chen, G. J., Lai, Y. J. & Wu, Y. R., 2014 Jul 16, In: PloS one. 9, 7, e101392.

  Research output: Contribution to journal › Article › peer-review

  • F-Box Proteins
  • F-box proteins
  • Parkinson disease
  • Polymorphism
  • Protective Factors
  8 Citations (Scopus)

• HTRA2 variations in Taiwanese Parkinson's disease

  Chen, C. M., Wu, C. H., Hsieh, C. H., Lin, C. H., Chen, I. C., Chen, Y. C., Lee, L. C., Lee, C. M., Tseng, Y. C., Lee-Chen, G. J. & Wu, Y. R., 2014 May, In: Journal of Neural Transmission. 121, 5, p. 491-498 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Parkinson Disease
  • technetium Tc 99m TRODAT-1
  • Single-Photon Emission-Computed Tomography
  • Late Onset Disorders
  • Mutation
  6 Citations (Scopus)

• Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

  Kung, P. J., Tao, Y. C., Hsu, H. C., Chen, W. L., Lin, T. H., Janreddy, D., Yao, C. F., Chang, K. H., Lin, J. Y., Su, M. T., Wu, C. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2014 Oct 16, In: Drug Design, Development and Therapy. 8, p. 1929-1939 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • polyglutamine
  • indole
  • Cell Culture Techniques
  10 Citations (Scopus)

• Role of High Mobility Group Box 1 (HMGB1) in SCA17 pathogenesis

  Lee, L. C., Chen, C. M., Wang, P. R., Su, M. T., Lee-Chen, G. J. & Chang, C. Y., 2014 Dec 30, In: PloS one. 9, 12, e115809.

  Research output: Contribution to journal › Article › peer-review

  • Spinocerebellar Ataxia 17
  • TATA-Box Binding Protein
  • pathogenesis
  • binding proteins
  • polyglutamine
  13 Citations (Scopus)

• The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems

  Lin, C. H., Wu, Y. R., Kung, P. J., Chen, W. L., Lee, L. C., Lin, T. H., Chao, C. Y., Chen, C. M., Chang, K. H., Janreddy, D., Lee-Chen, G. J. & Yao, C. F., 2014 Oct 15, In: ACS Chemical Neuroscience. 5, 10, p. 1063-1074 12 p.

  Research output: Contribution to journal › Article › peer-review

  • polyglutamine
  • indole
  • Autophagy
  • Agglomeration
  • Derivatives
  12 Citations (Scopus)

• Variant R244H in Na⁺/Mg²⁺ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg²⁺ efflux function

  Lin, C. H., Wu, Y. R., Chen, W. L., Wang, H. C., Lee, C. M., Lee-Chen, G. J. & Chen, C. M., 2014 Jun, In: Parkinsonism and Related Disorders. 20, 6, p. 600-603 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Parkinson Disease
  • Fluo 4
  • Wheat Germ Agglutinins
  • Fluorescent Dyes
  • Age of Onset
  9 Citations (Scopus)