2-Cyanoethylzinc iodide: A new reagent with reactivity umpolung

Ming Chang P. Yeh*, Paul Knochel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)


2-Cyanoethylzinc iodide 1 generated in over 90% yield from 3-iodopropionitrile and zinc in THF can be transmetallated to the copper and titanium derivatives 3 and 4 which react in good yields, respectively, with acyl chlorides, enones, allylic halides and benzaldehyde.

Original languageEnglish
Pages (from-to)2395-2396
Number of pages2
JournalTetrahedron Letters
Issue number20
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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