This study was to examine the effects of continuous maximal isokinetic voluntary eccentric training on the indicators of muscle damage and inflammatory response. Twenty-two healthy active males were recruited for the investigation (19.3 ± O.9yrs, 172.1 ± 4.9cm, 66.2 ± 4.2kg). Twelve subjects were randomly assigned to the eccentric training group (MAX) and ten were assigned to the control groups (CON). The initial exercise (MAX1) was 3 X 10 reps of maximal voluntary isokinetic eccentric contraction (MAX) on non-dominant elbow flexors with Cybex 6000 at a speed of 60 0/s. The MAX group performed the same exercise for the following 6 d after MAX1. None of the subjects had performed this eccentric exercise before this study. CIR, ROM, and MIF were measured before, immediately after, and every 24 h interval for 7 dafter MAX1. Plasma CK, LDH, GOT, and serum IL- 1 2 and IL-6 activities were assessed before, at 2 h, 1, 3, 4, 6, and 7 d after MAX1 (IL-i/3 and IL-6 were also analyzed at 2 h after MAX4 & MAX6). MSI was measured prior to the MAX1 and after that once a day for 7 d. The MAX1 produced significant changes in all measures for both groups (p＜.O5). Values remained significantly different from baseline (excepted LDH, GOT, MSI) on d 7 after MAX1 for both groups. Furthermore, no significant changes in all dependent variables were caused in MAX2-7. The continuous MAX training (MAX2-7) did not exacerbate all dependent variables (ROM, MIF, MSI, CIR, CK, LDH, GOT), but for IL-l /3 and IL-6 when performed by affected muscles that had not fully recovery from the MAX1. Therefore, it is concluded that a muscular ”adaptation effect” may occur within 24 h after the first exercise, when the MAX group performed 6 consecutive days MAX after MAX 1. In addition, intensive isokinetic voluntary eccentric training performed with damaged muscles did not aggravate damage or hinder the repair of muscle damage. This information has practical implications for athletes and coaches.