Purpose: To test the hypothesis that maximal eccentric exercise-induced muscle damage of the elbow flexors would produce significant changes in brachium artery stiffness and blood flow volume. Methods: Fifteen untrained young men performed a bout of 30 maximal isokinetic (30°/s) eccentric contractions of the elbow flexors of the non-dominant arm. Maximal isometric strength, muscle soreness, upper arm circumference, pulsatility index, resistance index, blood flow volume and heart rate measurements were taken before, immediately after, and for 4 consecutive days after maximal eccentric contractions. Results: Significant changes were noted in maximal isometric strength, upper arm circumference, muscle soreness, blood flow volume and pulsatility index following maximal eccentric exercise, and these variables had still not returned to baseline levels at 4 days after maximal eccentric contractions (p＜.05). No significant changes in heart rate and resistance index following maximal eccentric contractions were observed compared with pre-maximal eccentric contractions levels. Conclusion: These results suggest that the high tension produced during maximal eccentric exercise to the exercised muscles (e.g. maximal isometric strength loss) and blood tissues (decrease in pulsatility index) would produce microtrauma, launching a series of inflammatory response events. This in turn would lead to further increases in artery blood flow volume, in order to gain more oxygen and nutrient materials for the repair/regeneration of damaged tissue.