種子胜 Lunasin 抑制肥胖相關的發炎反應與乳癌進展

Noncontagious chronic diseases have turned into a critical issue in the 21st century, because of the long term of medication, high incidence and high mortality. The best strategy to prevent these diseases is good dietary habits and lifestyles. Beyond their primary nutritional effects, scientists are interested in the health benefits of natural compounds in daily diet. Seed peptide lunasin is considered as one of potential agents in natural plants, was found in soy, wheat, barley, and other seeds, and has been demonstrated multiple bioactivities, such as anti-carcinogenesis, anti-inflammation, anti-oxidation, cholesterol regulated properties. Overweight and obesity are associated with several chronic diseases development, especially cancers. A chronic and low-grade inflammatory response usually accompanied the obese process. Immune cells infiltration and inflammatory cytokines secretion provide a microenvironment that is conducive to tumor growth. Breast cancer is one of the most common cancers among women worldwide, and its cause is close to obesity. This review briefly summarized multiple bioactivities of lunasin, and focused on obesity-related inflammatory response and breast cancer progression.