酚酸及其衍生物之降血糖生理活性、機制探討及改善因腦部組織胰島素抗性引起之失智症的評估

Diabetes mellitus (DM) and its complications are among the major targets for medical intervention in developed countries. DM is the 4th leading cause of death in Taiwan and the prevalence is growing nowadays. More than 95 % among all the cases belong to type II diabetes characterized as insulin resistance and resulted in hyperglycemic syndrome. Although some studies pertaining to the relation of phenolic acids to hypoglycemia, however, there is no systematic study yet. In this study, the insulin resistant FL83B mouse hepatocytes cell model was established and used as screen platform. The cell viability test showed that the critical safe dosage of phenolic acids is 12.5μM. The result revealed that vanillic acid exhibit the highest enhancement on glucose uptake in insulin resistant cells among tested samples. Furthermore, animal model is performed to assess the potentials of vanillic acid in the reduction of blood sugar level in high fat diet-induced diabetic rats. Male Wistar rats fed an HFD for 16 weeks were orally administered vanillic acid (30 mg/kg body weight) during the last 4 weeks. This treatment reduced fasting blood glucose and triglyceride levels in HFD rats. We thus demonstrated the therapeutic potential of vanillic acid in the development of health foods or dietary supplements to prevent hypertriglyceridemia and hyperglycemia in diabetes mellitus.