耐力運動調控粒線體功能對早期糖尿病腎臟病變的影響

Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in type 2 diabetes. We examined the protective effects of moderate intensity aerobic exercise on kidney function in diabetic db/db mice. Functional and morphological alterations and metabolic and inflammatory signaling were examined in type 2 diabetic db/db mice with or without exercise training (5.2m/min, 1h/day, and 5days/week for a total of 8weeks). Exercise training prevented weight gain in db/db+Ex mice, but it did not reduce glucose and insulin levels. Exercise lowered serum creatinine, urea, and triglyceride levels in db/db+Ex mice. Reduced kidney size and morphological alterations including decreased glomerular cross-sectional area were observed in db/db+Ex mice compared with untrained db/db mice. Mechanistically, preventing loss of SIRT1 through exercise was linked to reduced acetylation of NF-κB in kidney of db/db+Ex mice. Exercise increased citrate synthase and mitochondrial complex I activity, subunits of mitochondrial complexes (I, II, and V) and PGC1a at protein level in kidney of db/db+Ex mice compared with non-exercise db/db mice. In conclusion, moderate exercise training modulates metabolic dysfunction and inflammatory process, thereby attenuating the progression of diabetic nephropathy in type 2 diabetes mellitus.