有機手性催化連鎖反應:具手性中心之多官能基碳/雜環狀化合物之合成(3/3)

We have developed efficient organocascade reactions for the synthesis of multifunctionalized products for the last several years. The obtained products included: pyrano-annulated scaffolds, tricyclic skeletons that containing O,O-acetal and N,O-aminal, bicyclo[3.3.1]nonan-9-one, oxa-bridged 2,6-epoxybenzo[b][1,5]-oxazocine heterocycles, bicyclic nitrones skeleton, dihydropyrano[2,3-b]chromene-2,5-dione and etc. The complex products were synthesized from simple starting substrates in the presence of an organocatalyst, such as: DABCO, cinchona derived catalysts, L-proline derived catalysts. In general, the products were obtained with high to excellent stereoselectivity (dr and %ee) and high chemical yield. These reactions proceeded smoothly under the optimal reaction conditions and the products were fully characterized by 1H NMR, 13C NMR, HRMS, single crystal x-ray analysis. The stereoselectivity (dr and %ee) was determined by chiral HPLC analyses.