探討與身體活動及運動訓練相關的微型核糖核酸對肌少症的影響

Functional and physiological adaptations induced by resistance training have been extensively studied in older adults. However, microRNA (miRNA) as the novel regulator in this protective effect remains poorly understood. 19 healthy older adults without previous resistance training experience were recruited. Blood samples were collected at baseline (PRE) and after 12 week of resistance training (POST). Next-generation sequencing (NGS) was used to determine circulating microRNA responses to chronic resistance training. Physical function, including grip strength, chair stand test, and walking capacity, was improved in older adults after 12-week training. Serum levels of leptin (18.1 ± 20.0 vs. 14.9 ± 17.6 ng/ml, P < 0.05) and TNFa (4.4 ± 0.6 vs. 4.0 ± 0.6 pg/ml, P < 0.01) were significantly decreased after 12-week training. After 12 week of resistance training, adipogenesis-, myogenesis-, and inflammation-associated miRNAs were significantly changed in older adults (Fold change > 2, P < 0.05). Log2 fold changes of miRNA-155-3p and miRNA-499a-5p were correlated with delta skinfold thickness and change in IGF-1. Log2 fold change of miRNA-125-1-3p was inversely correlated with delta walking time and change in IGF-1. Resistance training alters specific circulating miRNAs to account for functional and physiological adaptations in older adults.