探討糖化終產物對肌肉及脂肪組織代謝之影響：以不同性別及年齡層受試者和小鼠為研究對象

Sarcopenia is characterized by a decline in skeletal muscle mass and strength with age, which can lead to decreased physical function and increased risk of mortality. This study aimed to investigate the potential impact of long-term consumption of diets high in advanced glycation end products (AGEs) on muscle and adipose function in non-obese mice during middle and old age. In the study, the experimental animals were divided into a control diet group and a high-AGEs diet group starting from 3 weeks of age, and were sacrificed and analyzed at 64, 80, and 96 weeks of age, respectively. The results showed that feeding the high-AGEs diet significantly increased skin AGE fluorescence intensity in both male and female mice at 64, 80, and 96 weeks of age compared to the control group. Regarding exercise performance, in the wire hanging test (muscle endurance), the suspension time for high-AGEs diet mice was significantly lower than the control group for males at 64 and 96 weeks of age, and for females at 80 and 96 weeks of age. In the grip strength test (instantaneous explosive power), the grip strength of both male and female mice in the high-AGEs group was also significantly lower than the control group, indicating that long-term AGEs intake leads to a decrease in muscle endurance and strength. In terms of tissue changes, the gastrocnemius muscle index and brown adipose tissue index of male mice at 96 weeks of age in the high-AGEs group were significantly lower than the control group. Notably, the food intake, fasting glucose concentration, insulin sensitivity, and cognitive function at 96 weeks of age showed no significant differences between groups, regardless of diet or sex. In summary, feeding mice a high-AGEs diet until 96 weeks of age, compared to normal diet mice, resulted in a significant reduction in muscle mass and muscle endurance. The research team will further analyze the potential causes and mechanisms underlying this phenomenon due to long-term AGEs intake.