應用氧化腈進行1,3-偶極加成反應或使用碘分子或錸化物為催化劑來合成有機化合物(3/3)

Since August 2023 till now, we have published 6 papers in different international journals. A Pd-catalyzed regioselective hydroarylation of terminal alkynes containing a heteroatom has been developed via carbopalladation for the synthesis of allylic ethers, amines, and homoallylic alcohols. Moreover, hydroalkenylation of alkynes produces a variety of stereodefined 1,4-dienes with high regioselectivity. The important features of the present protocol are that it is highly regioselective, operationally rapid, and scalable with a huge substrate scope using only 3 mol% of PdCl 2 (PPh 3 ) 2 catalyst in the presence of a mild base KOAc. A cascade reaction between 2-styrylbenzaldehydes and indoles has been developed for the synthesis of 1H-indenes. An iodine-catalyzed nucleophilic addition of indoles to an aldehyde group of 2-styrylbenzaldehydes leads to the formation of carbocation intermediates that undergo 4π-electrocyclization to give indenes with a trisubstituted double bond. These indenes are transformed into thermodynamically more stable products with a fully substituted double bond under the reaction conditions. A transition metal-free method to readily assemble 4- indolylquinoline bis-heterocycles has been established using 2-methyleneaminochalcones and indoles in the presence of BF 3 ‧OEt 2 and ,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).