建置中老年人急性健身運動與神經認知功能之健身運動處方：容量、強度、時間及ApoE基因之角色

A certain amount of cognitive decline with age. Current research has demonstrated that exercise, one of crucial lifestyle factors, might reduce age-related cognitive decline. The relationships of exercise and cognition have been recognized as one of the most important issues in the exercise psychology. Although meta-analytic studies have revealed the positive effects of acute exercise on cognitive function, establishing an effective exercise prescription rely on FITT-VP principle is still lacked. Moreover, the cognitive changes response to acute exercise could be moderated by individual characteristics. The evidence had shown that ApoE E4 carriers have higher risk of developing the Alzheimer's disease. The purpose of the present study was to examine the relationship between cognition and acute exercise based on FITT-VP principle: the role of Apoe E4. 32 middle-aged adults without ApoE E4 carrier and 15 middle-aged adults with ApoE E4 carrier were recruited. The intervention consisted of three exercise conditions including one 40-min low intensity, one 30-min moderate intensity, and one 26-min high intensity exercise, with the same of total volume of energy expenditure. In addition, a reading session was included as the control condition. The order of the four conditions were counterbalanced. The results revealed that the significant positive effects on cognitive performance following each of the three exercise conditions, and the amount of beneficial effects of cognitive function are similar. The changes of P3 amplitude were induced by acute exercise is not significantly different from reading condition. Our findings suggested that the dose response of exercise intensity on cognitive function might be moderated by the total volume of exercise. The same volume of exercise programs regardless of exercise intensity might have similar amount of benefits on cognition. The acute exercise might improve cognitive performance via other mechanisms but not allocation of attentional resources.