多通道感測器應用於低場磁振造影/磁粒子造影整合系統之開發與生物磁造影研究

Magnetic resonance imaging (MRI) is a powerful imaging tool for clinical application which is a structure imaging tool for soft tissue. Magnetic particle imaging (MPI) is a kind of functional imaging tool for tracing magnetic particle. In order to localize the source position obtained from functional images, the imaging co-registration and fusion of functional image and structure image is necessary. If the functional imaging (MPI) and structure imaging (MRI) can be obtained in one system, the error form the co-registration will be minimized. Therefore, in this project, entitled “The study on multi-channel detector for the application on hybrid ultra low field magnetic resonance imaging/ magnetic particle imaging system for biomagnetic imaging”, We will further design and develop multi-channel pick-up coils to improve the imaging quality of low-field MRI system, and with the array of magnetic particle imaging system, the imaging characteristics of the gelatin-agar phantom to test and optimize, as the future of medical magnetic imaging Tools for basic research. The detail works are described as follows: 1. The fabrication of high-Tc superconducting quantum interference device (SQUID) 2. The fabrication and optimization of array pick-coils for improving the sensitivity of low-field MRI system 3. To establish the integration image of gelatin-agar phantom, including the characteristic of MRI/MPI co-registration imaging for gelatin-agar phantom and magnetic particle.