不同強度阻力運動訓練對高齡糖尿病前期族群胰島素敏感性的影響

Introduction: Prevalence of type 2 diabetes continues to increase as more people live longer in Taiwan, thereby resulting in higher mortality and greater health-related costs. Aging population can develop type 2 diabetes mellitus (DM) in certain circumstances such as age-related muscle loss, visceral fat accumulation, and increased inflammatory response. Few data are available on the effects of different intensities of resistance training on body composition and systemic Inflammation. Therefore, optimal resistance training prescription for prediabetic older adults is still unknown. The purpose of the current investigation was to examine differences in body composition and systemic inflammation in relation to equal volumes of high and low intensity resistance training in nonobese older adults with prediabetes. Methods: Twenty four older adults with prediabetes completed 10-wk resistance training (n=12/group). Oral glucose tolerance test (OGTT) and blood samples were collected at baseline and after 10 week of resistance training. Results: Fasting plasma glucose was returned to a normal level (<100 mg/dL) in high-intensity group. AUC of OGTT (0-30min) was significantly decreased in low intensity group. Serum levels of MCP-1 and TNFa were significantly decreased after 10-week high-intensity (80% 1RM) resistance training. Anti-inflammatory cytokine, IL-10, was significantly increased after 10-week training in high-intensity group. There were no changes in IL-6 and CRP levels in both groups. Leptin was significantly decreased after 10-week low-intensity (40% 1RM) resistance training. Changes of TNFa and MCP-1 were correlated with changes of fasting glucose and AUC of OGTT (0-120 min). Fat mass and body fat percentage were increased unexpectedly after 10-week high-intensity resistance training. Conclusions: These results indicate that matching volumes of high and low-intensity resistance training have distinct effects on glycemic control, and high-intensity resistance training has a more prominent effect on anti-inflammatory properties.