• 490 Citations
  • 12 h-Index
1993 …2020

Research output per year

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Research Output

  • 490 Citations
  • 12 h-Index
  • 37 Article
2020

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 Jan 1, (Accepted/In press) In : Journal of Molecular Neuroscience.

Research output: Contribution to journalArticle

2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 Feb 14, In : Psychopharmacology. 236, 2, p. 763-773 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2 Citations (Scopus)
2018

Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines

Li, H. Y., Lee, J. D., Chen, C. W., Sun, Y. C. & Cheng, W. C., 2018 Jan 20, In : European Journal of Medicinal Chemistry. 144, p. 626-634 9 p.

Research output: Contribution to journalArticle

2017

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 Aug 1, In : Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G. C. & Lee-Chen, G. J., 2016 Jun 30, In : European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Investigation of differences in the binding affinities of two analogous ligands for untagged and tagged p38 kinase using thermodynamic integration MD simulation

Sun, Y. C., Hsu, W. C., Hsu, C. J., Chang, C. M. & Cheng, K. H., 2015 Nov 1, In : Journal of Molecular Modeling. 21, 11, 283.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Using thermodynamic integration MD simulation to compute relative protein-ligand binding free energy of a GSK3β kinase inhibitor and its analogs

Lee, H. C., Hsu, W. C., Liu, A. L., Hsu, C. J. & Sun, Y. C., 2014 Jun, In : Journal of Molecular Graphics and Modelling. 51, p. 37-49 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Computation of relative binding free energy for an inhibitor and its analogs binding with erk kinase using thermodynamic integration md simulation

Wu, K. W., Chen, P. C., Wang, J. & Sun, Y. C., 2012 Oct 1, In : Journal of Computer-Aided Molecular Design. 26, 10, p. 1159-1169 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2011

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation

Tang, X. N., Lo, C. W., Chuang, Y. C., Chen, C. T., Sun, Y. C., Hong, Y. R. & Yang, C. N., 2011 Jul 1, In : Biopolymers. 95, 7, p. 461-471 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2010

Comparative molecular field analysis of anti-tubulin agents with indole ring binding at the colchicine binding site

Lin, I. H., Hsu, C. C., Wang, S. H., Hsieh, H. P. & Sun, Y. C., 2010 Feb 1, In : Journal of Theoretical and Computational Chemistry. 9, 1, p. 279-291 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2009

A 3D-QSAR study of celebrex-based PDK1 inhibitors using CoMFA method

Wang, W. H., Jena, N. R., Wang, Y. C. & Sun, Y. C., 2009 Jan 1, In : Journal of the Chinese Chemical Society. 56, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

A reversible surface functionalized nanowire transistor to study protein-protein interactions

Lin, S. P., Pan, C. Y., Tseng, K. C., Lin, M. C., Chen, C. D., Tsai, C. C., Yu, S. H., Sun, Y. C., Lin, T. W. & Chen, Y. T., 2009 Jun 1, In : Nano Today. 4, 3, p. 235-243 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
7 Citations (Scopus)
2008

Cytotoxicity and proteomics analyses of OSU03013 in lung cancer

Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F. & Wang, Y. C., 2008 Mar 15, In : Clinical Cancer Research. 14, 6, p. 1823-1830 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Packing of transmembrane helices in bacteriorhodopsin folding: Structure and thermodynamics

Chen, C. C., Wei, C. C., Sun, Y. C. & Chen, C. M., 2008 May 1, In : Journal of Structural Biology. 162, 2, p. 237-247 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2007

Examination of the folding of a short alanine-based helical peptide with salt bridges using molecular dynamics simulation

Wang, W. Z., Lin, T. & Sun, Y-C., 2007 Apr 5, In : Journal of Physical Chemistry B. 111, 13, p. 3508-3514 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Molecular dynamics simulation of folding of a short helical toxin peptide

Tsai, Y. L., Chen, H. W., Lin, T., Wang, W. Z. & Sun, Y. C., 2007 Jun 1, In : Journal of Theoretical and Computational Chemistry. 6, 2, p. 213-221 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2005

Molecular dynamics simulation of folding of a short helical peptide with many charged residues

Wei, C. C., Ho, M. H., Wang, W. H. & Sun, Y. C., 2005 Oct 27, In : Journal of Physical Chemistry B. 109, 42, p. 19980-19986 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Reactions of hydrazoic acid on TiO 2 nanoparticles: An experimental and computational study

Wang, J. H., Lin, M. C. & Sun, Y. C., 2005 Mar 24, In : Journal of Physical Chemistry B. 109, 11, p. 5133-5142 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2003

A Combined Quantum Chemistry and RRKM Calculation Predicts the O( 1D) + C2H6 Reaction Can Produce Water Molecule in a Collision-Free Crossed Molecular Beam Environment

Sun, Y. C., Wang, I. T., Nguyen, T. L., Lu, H. F., Yang, X. & Mebel, A. M., 2003 Sep 11, In : Journal of Physical Chemistry A. 107, 36, p. 6986-6994 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A theoretical study of face selectivity in the michael addition of a grignard reagent with 5-substituted-2-dicyanomethyleneadamantanes

Wu, P. F., Wang, I. T., Lu, H. F., Yao, C. F. & Sun, Y. C., 2003 Jan 1, In : Journal of the Chinese Chemical Society. 50, 3 B, p. 545-549 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2002
3 Citations (Scopus)
3 Citations (Scopus)

Self-complementarity of oligo-2-aminopyridines: A new class of hydrogen-bonded ladders

Leung, M. K., Mandal, A. B., Wang, C. C., Lee, G. H., Peng, S. M., Cheng, H. L., Her, G. R., Chao, I., Lu, H. F., Sun, Y-C., Shiao, M. Y. & Chou, P. T., 2002 Apr 24, In : Journal of the American Chemical Society. 124, 16, p. 4287-4297 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2001

Calculation of hydrogen abstraction reaction on hydrogen-covered H/C(1 1 1) diamond surface abstracted by non-hydrocarbon species

Lu, H. F. & Sun, Y. C., 2001 Nov 10, In : Surface Science. 494, 1, p. L787-L792

Research output: Contribution to journalArticle

9 Citations (Scopus)
2000
7 Citations (Scopus)
1999

A 500-ps molecular dynamics simulation trajectory of cardiotoxin II from Taiwan cobra venom in solution: Correlation with NMR and X-ray crystallography data

Sun, Y-C., Yang, S. F., Hwang, I. L. & Wu, T. H., 1999 Apr 15, In : Journal of Computational Chemistry. 20, 5, p. 546-562 17 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1998
5 Citations (Scopus)
1997
10 Citations (Scopus)
1996

Free energy calculations of the mutation of Ile96 → Ala in barnase: Contributions to the difference in stability

Sun, Y. C., Veenstra, D. L. & Kollman, P. A., 1996 Mar 1, In : Protein Engineering. 9, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Vibrational energy relaxation dynamics of Si-H stretching modes on stepped H/Si(111)1 × 1 surfaces

Sun, Y. C., Gai, H. & Voth, G. A., 1996 Apr 15, In : Chemical Physics. 205, 1-2 SPEC. ISS., p. 11-22 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1995

Vibrational energy relaxation dynamics of SiH stretching modes on stepped H/Si(111) 1×1 surfaces

Sun, Y. C., Gai, H. & Voth, G. A., 1995 Nov 15, In : Chemical Physics. 200, 3, p. 357-368 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1994

Vibrational energy relaxation dynamics of C-H stretching modes on the hydrogen-terminated H/C(111)1x1 surface

Sun, Y. C., Gai, H. & Voth, G. A., 1994 Jan 1, In : The Journal of Chemical Physics. 100, 4, p. 3247-3251 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1993

Path integral calculation of hydrogen diffusion rates on metal surfaces

Sun, Y. C. & Voth, G. A., 1993 Jan 1, In : The Journal of Chemical Physics. 98, 9, p. 7451-7458 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)