• 452 Citations
  • 12 h-Index
19952019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 452 Citations
  • 12 h-Index
  • 36 Article
Filter
Article
2019

Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation

Chang, W. C., Yang, Z. J., Tu, Y. H. & Chien, T. C., 2019 Jan 4, In : Organic Letters. 21, 1, p. 228-232 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Total synthesis of pseudouridine: Via Heck-type C-glycosylation

Yu, C. P., Chang, H. Y. & Chien, T. C., 2019 Jan 1, In : New Journal of Chemistry. 43, 22, p. 8796-8803 8 p.

Research output: Contribution to journalArticle

2018

A selective glucose sensor: The cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

Tsai, C. H., Tang, Y. H., Chen, H. T., Yao, Y. W., Chien, T. C. & Kao, C. L., 2018 Jan 1, In : Chemical Communications. 54, 36, p. 4577-4580 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Investigation of O-Sulfonylation-promoted Heterolytic NO Bond Cleavage of Amidoximes and Ketoximes

Hsieh, T. H., Liao, P. Y., Liu, Y. T., Wang, C. H., Lin, C. C. & Chien, T. C., 2018 Mar, In : Journal of the Chinese Chemical Society. 65, 3, p. 325-330 6 p.

Research output: Contribution to journalArticle

Regioselective synthesis and biological evaluation of: N -substituted 2-aminoquinazolin-4-ones

Liao, Z. Y., Yeh, W. H., Liao, P. Y., Liu, Y. T., Chen, Y. C., Chen, Y. H., Hsieh, T. H., Lin, C. C., Lu, M. H., Chen, Y. S., Hsu, M. C., Li, T. K. & Chien, T. C., 2018 Jan 1, In : Organic and Biomolecular Chemistry. 16, 24, p. 4482-4494 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Wang, Y. R., Chen, S. F., Wu, C. C., Liao, Y. W., Lin, T. S., Liu, K. T., Chen, Y. S., Li, T. K., Chien, T. C. & Chan, N. L., 2017 Oct 13, In : Nucleic Acids Research. 45, 18, p. 10861-10871 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2016

CuI-Catalyzed intramolecular aminocyanation of terminal alkynes in N-(2-ethynylphenyl)-N-sulfonylcyanamides via Cu-vinylidene intermediates

Liao, Z. Y., Liao, P. Y. & Chien, T. C., 2016 Jan 1, In : Chemical Communications. 52, 100, p. 14404-14407 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Green fluorescent protein chromophore derivative suppresses ultraviolet A-induced JNK-signalling and apoptosis in keratinocytes and adverse effects in zebrafish embryos

Wu, N. L., Lee, T. A., Wang, S. F., Li, H. J., Chen, H. T., Chien, T. C., Huang, C. C. & Hung, C. F., 2016 Dec 1, In : Experimental Dermatology. 25, 12, p. 983-990 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Identification of Reactive Intermediates for the Decarbonylative Reaction of 1-Alkylprolines

Shih, Y. C., Wang, J. S., Hsu, C. C., Tsai, P. H. & Chien, T. C., 2016 Dec 15, In : Synlett. 27, 20, p. 2841-2845 5 p., st-2016-u0387-l.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids

Shih, Y. C., Tsai, P. H., Hsu, C. C., Chang, C. W., Jhong, Y., Chen, Y. C. & Chien, T. C., 2015 Jul 2, In : Journal of Organic Chemistry. 80, 13, p. 6669-6678 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

One-Pot Synthesis of N-Monosubstituted Ureas from Nitriles via Tiemann Rearrangement

Wang, C. H., Hsieh, T. H., Lin, C. C., Yeh, W. H., Lin, C. A. & Chien, T. C., 2015 Aug 12, In : Synlett. 26, 13, p. 1823-1826 4 p., st-2015-u0285-l.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

Copper(i) iodide-catalyzed synthesis of N,N′-disubstituted guanidines from n-substituted cyanamides

Zeng, C. J., Chen, C. J., Chang, C. W., Chen, H. T. & Chien, T. C., 2014, In : Australian Journal of Chemistry. 67, 7, p. 1134-1137 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Practical synthesis of N -substituted cyanamides via tiemann rearrangement of amidoximes

Lin, C. C., Hsieh, T. H., Liao, P. Y., Liao, Z. Y., Chang, C. W., Shih, Y. C., Yeh, W. H. & Chien, T. C., 2014 Feb 7, In : Organic Letters. 16, 3, p. 892-895 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2013

Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C-H bond activation

Cheng, C., Shih, Y. C., Chen, H. T. & Chien, T. C., 2013 Jan 28, In : Tetrahedron. 69, 4, p. 1387-1396 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthesis and unexpected oxidization of the tricyclic core of ugibohlin, isophakellin, and styloguanidine

Chang, C. W., Wu, C. C., Chang, Y. Y., Lin, C. C. & Chien, T-C., 2013 Oct 18, In : Journal of Organic Chemistry. 78, 20, p. 10459-10468 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl grignard reagents

Shih, Y. C., Yang, Y. Y., Lin, C. C. & Chien, T-C., 2013 Apr 19, In : Journal of Organic Chemistry. 78, 8, p. 4027-4036 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Analysis of UDP-D-apiose/UDP-D-xylose synthase-catalyzed conversion of UDP-D-apiose phosphonate to UDP-D-xylose phosphonate: Implications for a retroaldol-aldol mechanism

Choi, S. H., Mansoorabadi, S. O., Liu, Y. N., Chien, T. C. & Liu, H. W., 2012 Aug 29, In : Journal of the American Chemical Society. 134, 34, p. 13946-13949 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

Lee, C. Y., Chen, Y. C., Lin, H. C., Jhong, Y., Chang, C. W., Tsai, C. H., Kao, C. L. & Chien, T. C., 2012 Jul 22, In : Tetrahedron. 68, 29, p. 5898-5907 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2011

Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

Shih, Y. C. & Chien, T. C., 2011 May 27, In : Tetrahedron. 67, 21, p. 3915-3923 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives

Lin, J. B., He, J. L., Shih, Y. C. & Chien, T. C., 2011 Aug 3, In : Tetrahedron Letters. 52, 31, p. 3969-3972 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2010

Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

Wu, Y. J., Liao, C. C., Jen, C. H., Shih, Y. C. & Chien, T. C., 2010 Jul 14, In : Chemical Communications. 46, 26, p. 4821-4823 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Reinvestigation of the synthesis of 1-deazauridine

Jen, C. H. & Chien, T. C., 2010 Jul 1, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 7, p. 523-534 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2008
1 Citation (Scopus)

Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.

Chien, T. C., Drach, J. C. & Townsend, L. B., 2008 Dec 1, In : Nucleic acids symposium series (2004). 52, p. 593-594 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2007

2007年第三十九屆國際化奧林匹克實作競賽試題參考解答評分標凖

方泰山, 張一知, 簡敦誠, 金必耀 & 陳雅玲, 2007, In : 科學教育月刊. 304, p. 49-52 4 p.

Research output: Contribution to journalArticle

2005
6 Citations (Scopus)

Synthesis of 3-aminoimidazo[4,5-c]pyrazole nucleoside via the N-N bond formation strategy as a [5:5] fused analog of adenosine

Chien, T. C., Berry, D. A., Drach, J. C. & Townsend, L. B., 2005 Sep 1, In : Nucleosides, Nucleotides and Nucleic Acids. 24, 10-12, p. 1971-1996 26 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2004
16 Citations (Scopus)

Facile synthesis of 1-substituted 2-amino-3-cyanopyrroles: New synthetic precursors for 5,6-unsubstituted pyrrolo[2,3-d]pyrimidines

Chien, T. C., Meade, E. A., Hinkley, J. M. & Townsend, L. B., 2004 Aug 19, In : Organic Letters. 6, 17, p. 2857-2859 3 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Facile synthesis of 1-substituted 4,5-diaminopyrazoles and its application toward the synthesis of pyrazolo[3,4-b]pyrazines

Chien, T-C., Smaldone, R. A. & Townsend, L. B., 2004 May 17, In : Tetrahedron Letters. 45, 21, p. 4105-4108 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Mononuclear heterocyclic rearrangement: Synthesis of [5:5] bicyclic [c]-fused 3-aminopyrazoles via the N-N bond formation strategy

Berry, D. A., Chien, T. C. & Townsend, L. B., 2004 Nov 1, In : Heterocycles. 63, 11, p. 2475-2494 20 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Nucleosides. IX. Synthesis of Purine N3,5′ -Cyclonucleosides and N3,5′-Cyclo-2′,3′ -seconucleosides via Mitsunobu Reaction as TIBO-like Derivativest

Chen, G. S., Chen, C. S., Chien, T. C., Yeh, J. Y., Kuo, C. C., Talekar, R. S. & Chern, J. W., 2004 Mar 26, In : Nucleosides, Nucleotides and Nucleic Acids. 23, 1-2, p. 347-359 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Nucleosides XI. Synthesis and antiviral evaluation of 5′-alkylthio- 5′-deoxy quinazolinone nucleoside derivatives as S-adenosyl-L-homocysteine analogs

Chien, T. C., Chen, C. S., Yu, F. H. & Chern, J. W., 2004 Dec 1, In : Chemical and Pharmaceutical Bulletin. 52, 12, p. 1422-1426 5 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Nucleosides XII.1 synthesis of 5′-modified isoguanosines and reinvestigation of 5′-deoxy-N3,5′-cycloisoguanosine

Chien, T. C., Kuo, C. C., Chen, C. S. & Chern, J. W., 2004 Jan 1, In : Journal of the Chinese Chemical Society. 51, 6, p. 1401-1406 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: Dimensional analogues of 2,5,6-trichloro-1-(β-D-ribofuranosyl) benzimidazole

Chien, T. C., Saluja, S. S., Drach, J. C. & Townsend, L. B., 2004 Nov 4, In : Journal of Medicinal Chemistry. 47, 23, p. 5743-5752 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
1995

Nucleosides VII:1 Synthesis of N-triphenylphosphoranylidene nucleosides by mitsunobu reaction. A novel protecting group for primary amines of nucleosides

Chien, T. C., Chen, C. S., Yeh, J. Y., Wang, K. C. & Chern, W., 1995 Oct 23, In : Tetrahedron Letters. 36, 43, p. 7881-7884 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)