Research Output per year
Fingerprint Dive into the research topics where Ling-Hsien Tu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Amyloid
Medicine & Life Sciences
Islet Amyloid Polypeptide
Medicine & Life Sciences
Oligomers
Chemical Compounds
Medical problems
Chemical Compounds
Type 2 Diabetes Mellitus
Medicine & Life Sciences
Mass spectrometry
Chemical Compounds
Cytotoxicity
Chemical Compounds
Poisons
Medicine & Life Sciences
Network
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Research Output 2004 2018
Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity
Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C. S., Fang, J. M. & Chen, Y. R., 2018 Oct 5, In : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.Research output: Contribution to journal › Article
Dissociative Disorders
Cytotoxicity
Amyloid
Amides
Alzheimer Disease
14
Citations
(Scopus)
A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP
Serrano, A. L., Lomont, J. P., Tu, L-H., Raleigh, D. P. & Zanni, M. T., 2017 Nov 22, In : Journal of the American Chemical Society. 139, 46, p. 16748-16758 11 p.Research output: Contribution to journal › Article
Energy barriers
Oligomers
Amyloid
Free energy
Poisons
7
Citations
(Scopus)
Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers
Young, L. M., Tu, L-H., Raleigh, D. P., Ashcroft, A. E. & Radford, S. E., 2017 Jan 1, In : Chemical Science. 8, 7, p. 5030-5040 11 p.Research output: Contribution to journal › Article
Oligomers
Amyloid
Copolymerization
Islet Amyloid Polypeptide
Electrospray ionization
50
Citations
(Scopus)
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
Akter, R., Cao, P., Noor, H., Ridgway, Z., Tu, L-H., Wang, H., Wong, A. G., Zhang, X., Abedini, A., Schmidt, A. M. & Raleigh, D. P., 2016 Jan 1, In : Journal of Diabetes Research. 2016, 2798269.Research output: Contribution to journal › Article
Islet Amyloid Polypeptide
Amyloid
Type 2 Diabetes Mellitus
Cell Death
Type 1 Diabetes Mellitus
37
Citations
(Scopus)
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Abedini, A., Plesner, A., Cao, P., Ridgway, Z., Zhang, J., Tu, L-H., Middleton, C. T., Chao, B., Sartori, D. J., Meng, F., Wang, H., Wong, A. G., Zanni, M. T., Verchere, C. B., Raleigh, D. P. & Schmidt, A. M., 2016 May 23, In : eLife. 5Research output: Contribution to journal › Article
Time and motion study
Poisons
Amyloidosis
Oligomers
Toxicity