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Fingerprint Dive into the research topics where Ling-Hsien Tu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Islet Amyloid Polypeptide Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Oligomers Chemical Compounds
Medical problems Chemical Compounds
Type 2 Diabetes Mellitus Medicine & Life Sciences
Mass spectrometry Chemical Compounds
Cytotoxicity Chemical Compounds
Poisons Medicine & Life Sciences

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Research Output 2004 2018

  • 642 Citations
  • 13 h-Index
  • 17 Article
  • 1 Commissioned report
  • 1 Review article

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C. S., Fang, J. M. & Chen, Y. R., 2018 Oct 5, In : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.

Research output: Contribution to journalArticle

Caffeic Acids
Peptide Fragments
Amyloid beta-Peptides
Cytotoxicity
Amyloid
13 Citations (Scopus)

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

Serrano, A. L., Lomont, J. P., Tu, L-H., Raleigh, D. P. & Zanni, M. T., 2017 Nov 22, In : Journal of the American Chemical Society. 139, 46, p. 16748-16758 11 p.

Research output: Contribution to journalArticle

Energy barriers
Oligomers
Amyloid
Free energy
Poisons
7 Citations (Scopus)

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers

Young, L. M., Tu, L-H., Raleigh, D. P., Ashcroft, A. E. & Radford, S. E., 2017 Jan 1, In : Chemical Science. 8, 7, p. 5030-5040 11 p.

Research output: Contribution to journalArticle

Oligomers
Amyloid
Copolymerization
Islet Amyloid Polypeptide
Electrospray ionization
45 Citations (Scopus)

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

Akter, R., Cao, P., Noor, H., Ridgway, Z., Tu, L-H., Wang, H., Wong, A. G., Zhang, X., Abedini, A., Schmidt, A. M. & Raleigh, D. P., 2016 Jan 1, In : Journal of Diabetes Research. 2016, 2798269.

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Amyloid
Type 2 Diabetes Mellitus
Cell Death
Type 1 Diabetes Mellitus
35 Citations (Scopus)

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

Abedini, A., Plesner, A., Cao, P., Ridgway, Z., Zhang, J., Tu, L-H., Middleton, C. T., Chao, B., Sartori, D. J., Meng, F., Wang, H., Wong, A. G., Zanni, M. T., Verchere, C. B., Raleigh, D. P. & Schmidt, A. M., 2016 May 23, In : eLife. 5

Research output: Contribution to journalArticle

Time and motion study
Poisons
Amyloidosis
Oligomers
Toxicity