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Research Output

2020

Composite Scores of Plasma Tau and β-Amyloids Correlate with Dementia in down Syndrome

Fang, W. Q., Hwu, W. L., Chien, Y. H., Yang, S. Y., Chieh, J. J., Chang, L. M., Huang, A. C., Lee, N. C. & Chiu, M. J., 2020 Jan 15, In : ACS Chemical Neuroscience. 11, 2, p. 191-196 6 p.

Research output: Contribution to journalArticle

2018

Eight-channel AC magnetosusceptometer of magnetic nanoparticles for high-throughput and ultra-high-sensitivity immunoassay

Chieh, J. J., Wei, W. C., Liao, S. H., Chen, H. H., Lee, Y. F., Lin, F. C., Chiang, M. H., Chiu, M. J., Horng, H. E. & Yang, S. Y., 2018 Apr, In : Sensors (Switzerland). 18, 4, 1043.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Plasma biomarkers differentiate Parkinson's disease from atypical parkinsonism syndromes

Lin, C. H., Yang, S. Y., Horng, H. E., Yang, C. C., Chieh, J. J., Chen, H. H., Liu, B. H. & Chiu, M. J., 2018 Apr 27, In : Frontiers in Aging Neuroscience. 10, APR, 123.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Bioassay using blocking temperature: Interparticle interactions between biofunctionalized magnetic nanoparticles conjugated with biotargets

Wang, C. Y., Yang, T. W., Shen, D., Chen, K. L., Chen, J. M., Liao, S. H., Chieh, J. J., Yang, H. C. & Wang, L. M., 2017 Mar 27, In : Applied Physics Letters. 110, 13, 133701.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Blood beta-amyloid and tau in down syndrome: A comparison with Alzheimer's disease

Lee, N. C., Yang, S. Y., Chieh, J. J., Huang, P. T., Chang, L. M., Chiu, Y. N., Huang, A. C., Chien, Y. H., Hwu, W. L. & Chiu, M. J., 2017 Jan 17, In : Frontiers in Aging Neuroscience. 8, JAN, 316.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Characterizations of anti-alpha-fetoprotein- conjugated magnetic nanoparticles associated with alpha-fetoprotein for biomedical applications

Liao, S. H., Huang, H. S., Chieh, J. J., Su, Y. K., Tong, Y. F. & Huang, K. W., 2017 Sep 3, In : Sensors (Switzerland). 17, 9, 2018.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Plasma α-synuclein predicts cognitive decline in Parkinson's disease

Lin, C. H., Yang, S. Y., Horng, H. E., Yang, C. C., Chieh, J. J., Chen, H. H., Liu, B. H. & Chiu, M. J., 2017, In : Journal of Neurology, Neurosurgery and Psychiatry. 88, 10, p. 818-824 7 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Ultrasound-Induced Magnetic Imaging of Tumors Targeted by Biofunctional Magnetic Nanoparticles

Huang, K. W., Chieh, J. J., Yeh, C. K., Liao, S. H., Lee, Y. Y., Hsiao, P. Y., Wei, W. C., Yang, H. C. & Horng, H. E., 2017 Mar 28, In : ACS Nano. 11, 3, p. 3030-3037 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2016
21 Citations (Scopus)

Immunomagnetic reduction assay on des-gamma-carboxy prothrombin for screening of hepatocellular carcinoma

Chieh, J. J., Huang, K. W., Chuang, C. P., Wei, W. C., Dong, J. J. & Lee, Y. Y., 2016 Aug, In : IEEE Transactions on Biomedical Engineering. 63, 8, p. 1681-1686 6 p., 7273866.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Rapid and quantitative discrimination of tumour cells on tissue slices

Huang, K. W., Chieh, J. J., Liao, S. H., Wei, W. C., Hsiao, P. Y., Yang, H. C. & Horng, H. E., 2016 May 3, In : Nanotechnology. 27, 23, 235101.

Research output: Contribution to journalArticle

2 Citations (Scopus)

SQUIDs in biomagnetism: A roadmap towards improved healthcare

Körber, R., Storm, J. H., Seton, H., Makela, J. P., Paetau, R., Parkkonen, L., Pfeiffer, C., Riaz, B., Schneiderman, J. F., Dong, H., Hwang, S. M., You, L., Inglis, B., Clarke, J., Espy, M. A., Ilmoniemi, R. J., Magnelind, P. E., Matlashov, A. N., Nieminen, J. O., Volegov, P. L. & 9 others, Zevenhoven, K. C. J., Höfner, N., Burghoff, M., Enpuku, K., Yang, S. Y., Chieh, J. J., Knuutila, J., Laine, P. & Nenonen, J., 2016 Sep 19, In : Superconductor Science and Technology. 29, 11, 113001.

Research output: Contribution to journalReview article

Open Access
34 Citations (Scopus)
2015

Assaying Carcinoembryonic Antigens by Normalized Saturation Magnetization

Huang, K. W., Chieh, J. J., Shi, J. C. & Chiang, M. H., 2015 Dec 23, In : Nanoscale Research Letters. 10, 1, 277.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dual-imaging model of SQUID biosusceptometry for locating tumors targeted using magnetic nanoparticles

Chieh, J-J., Huang, K. W., Lee, Y. Y. & Wei, W. C., 2015 Feb 12, In : Journal of Nanobiotechnology. 13, 1, 11.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Magnetic clustering effect during the association of biofunctionalized magnetic nanoparticles with biomarkers

Chen, K. L., Chen, J. H., Liao, S. H., Chieh, J. J., Horng, H. E., Wang, L. M. & Yang, H. C., 2015 Aug 13, In : PloS one. 10, 8, e0135290.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Multifunctional Nanomaterials for Biomedical Engineering: Unique Properties, Fabrications, and Diverse Applications

Chieh, J. J., Mukhopadhyay, S. M. & Cui, Y., 2015, In : Journal of Nanomaterials. 2015, 942698.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

Novel Integration of an Ultrasound Probe and a Rotational-Scanning SQUID Biosusceptometer for Diagnosing Liver Tumors

Chieh, J. J., Lee, Y. Y., Wei, W. C., Hsiao, P. Y. & Huang, K. W., 2015 Jun 1, In : IEEE Transactions on Applied Superconductivity. 25, 3, 6954474.

Research output: Contribution to journalArticle

Signal analysis and liver tumor discrimination by using a high-Tc SQUID-based low-field NMR system in hospital

Liao, S. H., Chieh, J. J., Chou, Y. T., Wang, M. W., Chen, H. H., Huang, K. W., Yang, H. C. & Horng, H. E., 2015 Jun 1, In : IEEE Transactions on Applied Superconductivity. 25, 3, 7012140.

Research output: Contribution to journalArticle

Sub-tesla-field magnetization of vibrated magnetic nanoreagents for screening tumor markers

Chieh, J-J., Huang, K. W. & Shi, J. C., 2015 Feb 16, In : Applied Physics Letters. 106, 7, 073703.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

Erratum: Discriminating hepatocellular carcinoma in rats using a high-Tc SQUID detected nuclear resonance spectrometer in a magnetic shielding box

Huang, K. W., Chen, H. H., Yang, H. C., Horng, H. E., Liao, S. H., Yang, S. Y., Chieh, J. J. & Wang, L. M., 2014 Jan 3, In : PloS one. 9, 1, 231.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)
21 Citations (Scopus)

Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early alzheimer's disease

Chiu, M. J., Chen, Y. F., Chen, T. F., Yang, S. Y., Yang, F. P. G., Tseng, T. W., Chieh, J. J., Chen, J. C. R., Tzen, K. Y., Hua, M. S. & Horng, H. E., 2014 Jul, In : Human Brain Mapping. 35, 7, p. 3132-3142 11 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Time-evolution contrast of target MRI using high-stability antibody functionalized magnetic nanoparticles: An animal model

Huang, K. W., Yang, S. Y., Horng, H. E., Chieh, J. J., Chen, H. H., Wu, C. C., Chen, J. H., Lin, I. T., Yang, C. C. & Yang, H. C., 2014 Jan 1, In : Journal of Nanomaterials. 2014, 351848.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Using bio-functionalized magnetic nanoparticles and dynamic nuclear magnetic resonance to characterize the time-dependent spin-spin relaxation time for sensitive bio-detection

Liao, S. H., Chen, K. L., Wang, C. M., Chieh, J. J., Horng, H. E., Wang, L. M., Wu, C. H. & Yang, H. C., 2014 Nov 12, In : Sensors (Switzerland). 14, 11, p. 21409-21417 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

Anti-CEA-functionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivo

Huang, K. W., Chieh, J. J., Lin, I. T., Horng, H. E., Yang, H. C. & Hong, C. Y., 2013 Jan 1, In : Nanoscale Research Letters. 8, 1, p. 1-8 8 p., 413.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Combined plasma biomarkers for diagnosing mild cognition impairment and Alzheimer's disease

Chiu, M. J., Yang, S. Y., Horng, H. E., Yang, C. C., Chen, T. F., Chieh, J. J., Chen, H. H., Chen, T. C., Ho, C. S., Chang, S. F., Liu, H. C., Hong, C. Y. & Yang, H. C., 2013 Dec 18, In : ACS Chemical Neuroscience. 4, 12, p. 1530-1536 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Development for high-accuracy in vitro assay of vascular endothelial growth factor using nanomagnetically labeled immunoassay

Yang, C. C., Huang, K. W., Yang, S. Y., Chen, H. H., Chen, T. C., Ho, C. S., Chang, S. F., Chieh, J. J., Horng, H. E., Hong, C. Y. & Yang, H. C., 2013 Oct 31, In : Journal of Nanomaterials. 2013, 695276.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Yang, H. C., Huang, K. W., Liao, S. H., Horng, H. E., Chieh, J. J., Chen, H. H., Chen, M. J., Chen, K. L. & Wang, L. M., 2013 Jan 7, In : Applied Physics Letters. 102, 1, 013119.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Experimental study on low-detection limit for immunomagnetic reduction assays by manipulating reagent entities

Yang, S. Y., Yang, C. C., Horng, H. E., Shih, B. Y., Chieh, J. J., Hong, C. Y. & Yang, H. C., 2013 Jun 12, In : IEEE Transactions on Nanobioscience. 12, 2, p. 65-68 4 p., 6451290.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Imaging the distribution of magnetic nanoparticles on animal bodies using scanning SQUID biosusceptometry attached with a video camera

Chieh, J. J., Horng, H. E., Tseng, W. K., Yang, S. Y., Hong, C. Y., Yang, H. C. & Wu, C. C., 2013 Feb 11, In : IEEE Transactions on Applied Superconductivity. 23, 3, 6359776.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Microtesla NMR and high resolution MR imaging using high-Tc SQUIDs

Liao, S-H., Chen, H. H., Deng, Y. S., Wang, M. W., Chen, K. L., Liu, C. W., Liu, C. I., Yang, H-C., Horng, H-E., Chieh, J-J. & Yang, S-Y., 2013 Feb 18, In : IEEE Transactions on Applied Superconductivity. 23, 3, 6401170.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Molecule-assisted nanoparticle clustering effect in immunomagnetic reduction assay

Yang, S-Y., Chieh, J-J., Huang, K. W., Yang, C. C., Chen, T. C., Ho, C. S., Chang, S. F., Chen, H. H., Horng, H-E., Hong, C. Y. & Yang, H-C., 2013 Apr 14, In : Journal of Applied Physics. 113, 14, 144903.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Stability study for magnetic reagent assaying Hb and HbA1c

Hsieh, W. P., Chieh, J. J., Yang, C. C., Yang, S. Y., Chen, P. Y., Huang, Y. H., Hong, Y. W. & Horng, H. E., 2013 Jan 1, In : Journal of Magnetism and Magnetic Materials. 326, p. 147-150 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Time-dependent phase lag of biofunctionalized magnetic nanoparticles conjugated with biotargets studied with alternating current magnetic susceptometor for liquid phase immunoassays

Liao, S. H., Yang, H. C., Horng, H. E., Chieh, J. J., Chen, K. L., Chen, H. H., Chen, J. Y., Liu, C. I., Liu, C. W. & Wang, L. M., 2013 Dec 9, In : Applied Physics Letters. 103, 24, 243703.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2012

A Noninvasive Method to Determine the Fate of Fe3O4 Nanoparticles following Intravenous Injection Using Scanning SQUID Biosusceptometry

Tseng, W. K., Chieh, J. J., Yang, Y. F., Chiang, C. K., Chen, Y. L., Yang, S. Y., Horng, H. E., Yang, H. C. & Wu, C. C., 2012 Nov 12, In : PloS one. 7, 11, e48510.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Characteristics of magnetic labeling on liver tumors with anti-alpha-fetoprotein-mediated Fe3O4 magnetic nanoparticles

Huang, K. W., Chieh, J. J., Horng, H. E., Hong, C. Y. & Yang, H. C., 2012, In : International Journal of Nanomedicine. 7, p. 2987-2996 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Discriminating Hepatocellular Carcinoma in Rats Using a High-Tc SQUID Detected Nuclear Resonance Spectrometer in a Magnetic Shielding Box

Huang, K. W., Chen, H. H., Yang, H. C., Horng, H. E., Liao, S. H., Yang, S. Y., Chieh, J. J. & Wang, L. M., 2012 Oct 5, In : PloS one. 7, 10, e47057.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents

Yang, C. C., Yang, S. Y., Chen, H. H., Weng, W. L., Horng, H. E., Chieh, J. J., Hong, C. Y. & Yang, H. C., 2012 Jul 15, In : Journal of Applied Physics. 112, 2, 024704.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Feasibility studies for assaying alpha-fetoprotein using antibody-activated magnetic nanoparticles

Huang, K. W., Yang, S. Y., Hong, Y. W., Chieh, J. J., Yang, C. C., Horng, H. E., Wu, C. C., Hong, C. Y. & Yang, H. C., 2012, In : International Journal of Nanomedicine. 7, p. 1991-1996 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Immunomagnetic reduction assay for nervous necrosis virus extracted from groupers

Lu, M. W., Yang, S. Y., Horng, H. E., Yang, C. C., Chieh, J. J., Hong, Y. W., Hong, C. Y., Yang, H. C. & Wu, J. L., 2012 Apr 1, In : Journal of Virological Methods. 181, 1, p. 68-72 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

In Vivo Screening of Hepatocellular Carcinoma Using AC Susceptibility of Anti-Alpha Fetoprotein-Activated Magnetic Nanoparticles

Chieh, J. J., Huang, K. W., Lee, Y. D., Horng, H. E., Yang, H. C. & Hong, C. Y., 2012 Oct 8, In : PloS one. 7, 10, e46756.

Research output: Contribution to journalArticle

6 Citations (Scopus)

In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles

Hsieh, W. J., Liang, C. J., Chieh, J. J., Wang, S. H., Lai, I. R., Chen, J. H., Chang, F. H., Tseng, W. K., Yang, S. Y., Wu, C. C. & Chen, Y. L., 2012, In : International Journal of Nanomedicine. 7, p. 2833-2842 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

New assay for old markers-plasma beta amyloid of mild cognitive impairment and Alzheimer's disease

Chiu, M. J., Yang, S-Y., Chen, T. F., Chieh, J-J., Huang, T. Z., Yip, P. K., Yang, H-C., Cheng, T. W., Chen, Y. F., Hua, M. S. & Horng, H-E., 2012 Dec 1, In : Current Alzheimer Research. 9, 10, p. 1142-1148 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The magnetic-nanofluid heat pipe with superior thermal properties through magnetic enhancement

Chiang, Y. C., Chieh, J. J. & Ho, C. C., 2012 Jan 1, In : Nanoscale Research Letters. 7, 322.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Universal behavior of biomolecule-concentration-dependent reduction in ac magnetic susceptibility of bioreagents

Yang, C. C., Yang, S. Y., Chieh, J. J., Horng, H. E., Hong, C. Y. & Yang, H. C., 2012 Mar 7, In : IEEE Magnetics Letters. 3, 6157673.

Research output: Contribution to journalArticle

19 Citations (Scopus)
6 Citations (Scopus)
2011

Biofunctionalized magnetic nanoparticles for specifically detecting biomarkers of Alzheimer's disease in vitro

Yang, C. C., Yang, S. Y., Chieh, J. J., Horng, H. E., Hong, C. Y., Yang, H. C., Chen, K. H., Shih, B. Y., Chen, T. F. & Chiu, M. J., 2011 May 30, In : ACS Chemical Neuroscience. 2, 9, p. 500-505 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Exploration of the relationship between the tumor burden and the concentration of vascular endothelial growth factor in liver-cancer-bearing animals using immunomagnetic reduction assay

Huang, K. W., Yang, S. Y., Yu, C. Y., Chieh, J. J., Yang, C. C., Horng, H. E., Hong, C. Y., Yang, H. C. & Wu, C. C., 2011 Aug 1, In : Journal of Biomedical Nanotechnology. 7, 4, p. 535-541 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

In-vivo and fast examination of iron concentration of magnetic nano-particles in an animal torso via scanning SQUID biosusceptometry

Tseng, W. K., Chieh, J-J., Yang, S-Y., Horng, H-E., Hong, C. Y., Yang, H-C. & Wu, C. C., 2011 Jun 1, In : IEEE Transactions on Applied Superconductivity. 21, 3 PART 2, p. 2250-2253 4 p., 5721748.

Research output: Contribution to journalArticle

5 Citations (Scopus)

In vivo and real-time measurement of magnetic nanoparticles distribution in animals by scanning SQUID biosusceptometry for biomedicine study

Chieh, J. J., Tseng, W. K., Horng, H. E., Hong, C. Y., Yang, H. C. & Wu, C. C., 2011 Oct 1, In : IEEE Transactions on Biomedical Engineering. 58, 10 PART 1, p. 2719-2724 6 p., 5613158.

Research output: Contribution to journalArticle

13 Citations (Scopus)