• 2875 Citations
  • 24 h-Index
1986 …2019
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Research Output 1986 2019

  • 2875 Citations
  • 24 h-Index
  • 140 Article
  • 2 Letter
2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 Feb 14, In : Psychopharmacology. 236, 2, p. 763-773 11 p.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
Hyperglycemia
N-(4-hydroxyphenyl)arachidonylamide
Cognitive Dysfunction
Inflammation

Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In : Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Alzheimer Disease
Biomarkers
Leukocytes
Down-Regulation
Alzheimer Disease
Inflammation
Green Fluorescent Proteins
p38 Mitogen-Activated Protein Kinases
Acetylcholinesterase

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019 Jan 1, In : Aging. 11, 3, p. 986-1007 22 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
GATA1 Transcription Factor
Medicine
Glycyrrhiza uralensis
Paeonia

Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3

Chen, I. C., Chang, C. N., Chen, W. L., Lin, T. H., Chao, C. Y., Lin, C. H., Lin, H. Y., Cheng, M. L., Chiang, M. C., Lin, J. Y., Wu, Y. R., Lee-Chen, G. J. & Chen, C. M., 2019 Jan 1, In : American Journal of Chinese Medicine. 47, 1, p. 63-95 33 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Chinese Traditional Medicine
Proteasome Endopeptidase Complex
Ubiquitin
Spinocerebellar Ataxias
2018

Chinese Herbal Medicine Glycyrrhiza inflata Reduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

Chiu, Y. J., Lee, C. M., Lin, T. H., Lin, H. Y., Lee, S. Y., Mesri, M., Chang, K. H., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2018 Jan 1, In : American Journal of Chinese Medicine. 46, 7, p. 1535-1549 15 p.

Research output: Contribution to journalArticle

Glycyrrhiza
Herbal Medicine
Amyloid
Apoptosis
Inflammation
1 Citation (Scopus)

Formulated Chinese medicine shaoyao gancao tang reduces tau aggregation and exerts neuroprotection through anti-oxidation and anti-inflammation

Chen, I. C., Lin, T. H., Hsieh, Y. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Lee, M. C., Lee-Chen, G. J. & Chen, C. M., 2018 Jan 1, In : Oxidative Medicine and Cellular Longevity. 2018, 9595741.

Research output: Contribution to journalArticle

Open Access
Glycyrrhiza uralensis
Medicine
Anti-Inflammatory Agents
Agglomeration
Inflammation

Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders

Chang, K. H., Lee, G-C., Huang, C. C., Kuo, H. C., Chen, C. M., Hsiao, Y. C., Hsu, H. C., Hsu, K. J., Lin, C. H., Chang, C. W., Lee, G-J. & Wu, Y. R., 2018 Jun 1, In : Parkinsonism and Related Disorders. 51, p. 61-66 6 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Mutation
Frontotemporal Dementia
Protein Stability
Kidney

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

Chang, K. H., Lee-Chen, G. J., Huang, C. C., Lin, J. L., Chen, Y. J., Wei, P. C., Lo, Y. S., Yao, C. F., Kuo, M. W. & Chen, C. M., 2018 Jan 1, (Accepted/In press) In : Molecular Neurobiology. 56, 6, p. 3972-3983 12 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Alzheimer Disease
Mutation
Neurons
Caspase 1
2 Citations (Scopus)

The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In : NeuroToxicology. 67, p. 259-269 11 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Agglomeration
Molecular Chaperones
Gene encoding
indole
2017

Functional properties of LRRK2 mutations in Taiwanese Parkinson disease

Chang, K. H., Chen, C. M., Lin, C. H., Chang, W. T., Jiang, P. R., Hsiao, Y. C., Wu, Y. R. & Lee-Chen, G. J., 2017 Mar 1, In : Journal of the Formosan Medical Association. 116, 3, p. 197-204 8 p.

Research output: Contribution to journalArticle

Leucine
Parkinson Disease
Phosphotransferases
Mutation
Synucleins
1 Citation (Scopus)

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee, G-J., Hsieh, H. M., Lee, G-C. & Sun, Y-C., 2017 Aug 1, In : Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Thermodynamics
Molecular dynamics
Assays
Phosphotransferases
7 Citations (Scopus)

The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1

Chang, K. H., Lin, C. H., Chen, H. C., Huang, H. Y., Chen, S. L., Lin, T. H., Ramesh, C., Huang, C. C., Fung, H. C., Wu, Y. R., Huang, H. J., Lee, G-J., Hsieh, H. M. & Yao, C-F., 2017 Jan 1, In : CNS Neuroscience and Therapeutics. 23, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Solubility
HSP27 Heat-Shock Proteins
Neurofibrillary Tangles
Cell Survival
2016
7 Citations (Scopus)

Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan

Chen, C. M., Chen, Y. C., Chiang, M. C., Fung, H. C., Chang, K. H., Lee-Chen, G. J. & Wu, Y. R., 2016 Mar 1, In : Neurobiology of Aging. 39, p. 221.e1-221.e5

Research output: Contribution to journalArticle

Taiwan
Parkinson Disease
Genome-Wide Association Study
Odds Ratio
Genetic Loci
10 Citations (Scopus)

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M-T., Sun, Y-C., Lee, G-C. & Lee, G-J., 2016 Jun 30, In : European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Enzyme Assays
Alzheimer Disease
Phosphotransferases
Databases
11 Citations (Scopus)

Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease

Chang, K. H., Lee, G-J., Wu, Y. R., Chen, Y. J., Lin, J. L., Li, M., Chen, I. C., Lo, Y. S., Wu, H. C. & Chen, C. M., 2016 Mar 1, In : Parkinsonism and Related Disorders. 24, p. 81-88 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Proteasome Endopeptidase Complex
Parkinson Disease
Synucleins
Neurons

Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression

Chen, C. M., Chen, I. C., Chen, Y. L., Lin, T. H., Chen, W. L., Chao, C. Y., Wu, Y. R., Lu, Y. T., Lee, C. Y., Chien, H. C., Chen, T. S., Lee, G-J. & Lee, C. M., 2016 Nov 15, In : Phytomedicine. 23, 12, p. 1422-1433 12 p.

Research output: Contribution to journalArticle

Oenanthe
F-Box Proteins
Sorghum
Medicinal Plants
TNF Receptor-Associated Factor 2
6 Citations (Scopus)

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G-C., Hsieh-Li, H. M., Lee, C. M. & Lee, G-J., 2016 Apr 1, In : CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

Research output: Contribution to journalArticle

Melibiose
Spinocerebellar Ataxias
Lactulose
Cell Aggregation
Autophagy
5 Citations (Scopus)

Targeting the prodromal stage of spinocerebellar ataxia type 17 mice: G-CSF in the prevention of motor deficits via upregulating chaperone and autophagy levels

Chang, Y. C., Lin, C. W., Hsu, C. M., Lee, G-J., Su, M-T., Ro, L. S., Chen, C. M., Huang, H. J. & Hsieh, H. M., 2016 Jan 1, In : Brain Research. 1639, p. 132-148 17 p.

Research output: Contribution to journalArticle

Prodromal Symptoms
Autophagy
Granulocyte Colony-Stimulating Factor
TATA-Box Binding Protein
Mutant Proteins
8 Citations (Scopus)

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang, K. H., Chen, I. C., Lin, H. Y., Chen, H. C., Lin, C. H., Lin, T. H., Weng, Y. T., Chao, C. Y., Wu, Y. R., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2016 Feb 29, In : Drug Design, Development and Therapy. 10, p. 885-896 12 p.

Research output: Contribution to journalArticle

Open Access
Glycyrrhiza
Unfolded Protein Response
Tauopathies
Alzheimer Disease
Up-Regulation
9 Citations (Scopus)

The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity

Chang, K. H., Chiu, Y. J., Chen, S. L., Huang, C. H., Lin, C. H., Lin, T. H., Lee, C. M., Ramesh, C., Wu, C-H., Huang, C. C., Fung, H. C., Chen, Y. C., Lin, J. Y., Yao, C-F., Huang, H. J., Lee, G-J., Lee, M. C. & Hsieh, H. M., 2016 Feb 1, In : Neuropharmacology. 101, p. 309-319 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Synaptophysin
Long-Term Potentiation
Amyloid Plaques
Memory Disorders
2015
2 Citations (Scopus)

Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population

Chen, Y. C., Huang, C. J., Chen, P., Wu, Y. R., Shie, S. S., Chen, S. T., Lee, G-J. & Chen, C. M., 2015 Sep 1, In : Biomedical Journal. 38, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

Taiwan
Protein Kinase C
Lacunar Stroke
Stroke
Odds Ratio
5 Citations (Scopus)

STK39, but Not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated with Han-Chinese Parkinson's disease in Taiwan

Chang, K. H., Wu, Y. R., Chen, Y. C., Fung, H. C., Lee, G-J. & Chen, C. M., 2015 Jan 1, In : Medicine (United States). 94, 41, e1690.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Taiwan
Parkinson Disease
Genotype
Confidence Intervals
7 Citations (Scopus)

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 May 1, In : NeuroToxicology. 48, p. 120-130 11 p.

Research output: Contribution to journalArticle

Melibiose
Trehalase
Neurodegenerative diseases
Lactulose
Trehalose
12 Citations (Scopus)

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

Chen, Z. Z., Wang, C. M., Lee, G. C., Hsu, H. C., Wu, T. L., Lin, C. W., Ma, C. K., Lee-Chen, G. J., Huang, H. J. & Hsieh-Li, H. M., 2015 Jan 1, In : Neurochemical Research. 40, 4, p. 800-810 11 p.

Research output: Contribution to journalArticle

Gait Ataxia
Trehalose
Gliosis
TATA-Box Binding Protein
Neurodegenerative diseases
2014
14 Citations (Scopus)

Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3

Chang, K. H., Chen, W. L., Wu, Y. R., Lin, T. H., Wu, Y. C., Chao, C. Y., Lin, J. Y., Lee, L. C., Chen, Y. C., Lee-Chen, G. J. & Chen, C. M., 2014 Jun 1, In : Neuropharmacology. 81, p. 166-175 10 p.

Research output: Contribution to journalArticle

geniposide
Gardenia
Machado-Joseph Disease
Cell Aggregation
Oxidative Stress
15 Citations (Scopus)

Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3

Chen, C. M., Weng, Y. T., Chen, W. L., Lin, T. H., Chao, C. Y., Lin, C. H., Chen, I. C., Lee, L. C., Lin, H. Y., Wu, Y. R., Chen, Y. C., Chang, K. H., Tang, H. Y., Cheng, M. L., Lee, G-J. & Lin, J. Y., 2014 Jan 1, In : Free Radical Biology and Medicine. 71, p. 339-350 12 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Glycyrrhiza
Ammonium Compounds
Agglomeration
Antioxidants
11 Citations (Scopus)

Deactivation of TBP contributes to SCA17 pathogenesis

Hsu, T. C., Wang, C. K., Yang, C. Y., Lee, L. C., Hsieh, H. M., Ro, L. S., Chen, C. M., Lee, G-J. & Su, M-T., 2014 Dec 20, In : Human molecular genetics. 23, 25, p. 6878-6893 16 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Diptera
Retinal Degeneration
Spinocerebellar Ataxia 17
Cerebellar Ataxia
5 Citations (Scopus)

Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17

Lee, L. C., Weng, Y. T., Wu, Y. R., Soong, B. W., Tseng, Y-C., Chen, C. M. & Lee, G-J., 2014 Jan 1, In : Journal of Neural Transmission. 121, 6, p. 601-610 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Down-Regulation
Proteins
Immunoblotting
Oxidative Stress
8 Citations (Scopus)

FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease

Chen, C. M., Chen, I. G., Huang, Y. C., Juan, H. F., Chen, Y. L., Chen, Y. C., Lin, C. H., Lee, L. C., Lee, C. M., Lee-Chen, G. J., Lai, Y. J. & Wu, Y. R., 2014 Jul 16, In : PLoS One. 9, 7, e101392.

Research output: Contribution to journalArticle

F-Box Proteins
F-box proteins
Parkinson disease
Polymorphism
Parkinson Disease
6 Citations (Scopus)

HTRA2 variations in Taiwanese Parkinson's disease

Chen, C. M., Wu, C. H., Hsieh, C. H., Lin, C. H., Chen, I. C., Chen, Y. C., Lee, L. C., Lee, C. M., Tseng, Y-C., Lee, G-J. & Wu, Y. R., 2014 Jan 1, In : Journal of Neural Transmission. 121, 5, p. 491-498 8 p.

Research output: Contribution to journalArticle

Parkinson Disease
Single-Photon Emission-Computed Tomography
Mutation
Virulence
Mitochondria
6 Citations (Scopus)

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Kung, P. J., Tao, Y. C., Hsu, H. C., Chen, W. L., Lin, T. H., Janreddy, D., Yao, C-F., Chang, K. H., Lin, J. Y., Su, M-T., Wu, C-H., Lee, G-J. & Hsieh, H. M., 2014 Oct 16, In : Drug Design, Development and Therapy. 8, p. 1929-1939 11 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Cell Culture Techniques
Molecular Chaperones
Purkinje Cells
Green Fluorescent Proteins
11 Citations (Scopus)

Role of High Mobility Group Box 1 (HMGB1) in SCA17 pathogenesis

Lee, L. C., Chen, C. M., Wang, P. R., Su, M-T., Lee, G-J. & Chang, C-Y., 2014 Dec 30, In : PLoS One. 9, 12, e115809.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
binding proteins
pathogenesis
autophagy
Autophagy
9 Citations (Scopus)

The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems

Lin, C. H., Wu, Y. R., Kung, P. J., Chen, W. L., Lee, L. C., Lin, T. H., Chao, C. Y., Chen, C. M., Chang, K. H., Janreddy, D., Lee-Chen, G. J. & Yao, C. F., 2014 Oct 15, In : ACS Chemical Neuroscience. 5, 10, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

Autophagy
Agglomeration
Derivatives
Proteins
Spinocerebellar Ataxias
6 Citations (Scopus)

Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function

Lin, C. H., Wu, Y. R., Chen, W. L., Wang, H. C., Lee, C. M., Lee, G-J. & Chen, C. M., 2014 Jan 1, In : Parkinsonism and Related Disorders. 20, 6, p. 600-603 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Wheat Germ Agglutinins
Fluorescent Dyes
Age of Onset
Homeostasis
2013
15 Citations (Scopus)

Aqueous extract of paeonia lactiflora and paeoniflorin as aggregation reducers targeting chaperones in cell models of spinocerebellar ataxia 3

Chang, K. H., Chen, W. L., Lee, L. C., Lin, C. H., Kung, P. J., Lin, T. H., Wu, Y. C., Wu, Y. R., Chen, Y. C., Lee, G-J. & Chen, C. M., 2013 Apr 2, In : Evidence-based Complementary and Alternative Medicine. 2013, 471659.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Paeonia
Spinocerebellar Ataxias
Huntington Disease
Neurodegenerative Diseases
9 Citations (Scopus)

Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population

Chang, K. H., Chen, C. M., Chen, Y. C., Hsiao, Y. C., Huang, C. C., Kuo, H. C., Hsu, H. C., Lee, G-J. & Wu, Y. R., 2013 Jan 16, In : PLoS ONE. 8, 1, e54448.

Research output: Contribution to journalArticle

Parkinson disease
Polymorphism
Parkinson Disease
genetic polymorphism
Population
11 Citations (Scopus)

Association between PARK16 and Parkinson's disease in the Han Chinese population: A meta-analysis

Chang, K. H., Chen, C. M., Chen, Y. C., Lyu, R. K., Chang, H. S., Ro, L. S., Lee, G-J. & Wu, Y. R., 2013 Jan 1, In : Neurobiology of Aging. 34, 10, p. 2442.e5-2442.e9

Research output: Contribution to journalArticle

Parkinson Disease
Meta-Analysis
Population
Alleles
Odds Ratio
1 Citation (Scopus)

Effect of statin treatment on adrenomyeloneuropathy with cerebral inflammation: A revisit

Shih, C. C., Wu, Y. R., Lee, G-J. & Chao, C. Y., 2013 May 1, In : Clinical Neurology and Neurosurgery. 115, 5, p. 624-627 4 p.

Research output: Contribution to journalArticle

Fluorobenzenes
Adrenoleukodystrophy
Dietary Cholesterol
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Pyrimidines
14 Citations (Scopus)

Genetic analysis of NFE2L2 promoter variation in Taiwanese Parkinson's disease

Chen, Y. C., Wu, Y. R., Wu, Y. C., Lee, G-J. & Chen, C. M., 2013 Feb 1, In : Parkinsonism and Related Disorders. 19, 2, p. 247-250 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Single Nucleotide Polymorphism
Disease Susceptibility
Haplotypes
Genome-Wide Association Study
21 Citations (Scopus)

Genetic variants of LRRK2 in Taiwanese Parkinson's disease

Wu, Y. R., Chang, K. H., Chang, W. T., Hsiao, Y. C., Hsu, H. C., Jiang, P. R., Chen, Y. C., Chao, C. Y., Chang, Y. C., Lee, B. H., Hu, F. J., Chen, W. L., Lee, G-J. & Chen, C. M., 2013 Dec 5, In : PLoS One. 8, 12, 0082001.

Research output: Contribution to journalArticle

Parkinson disease
Leucine
leucine
Parkinson Disease
phosphotransferases (kinases)

Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)

楊淑婷(Shu-Ting Y, 陳襄銘(Hsiang-Ming C, 李麗卿(Li-Ching L, 黃詩涵(Shih-Han H, 林志信(Chih-Hsin L, 李冠群(Guan-Chiun L, 李振綱(Cheng-Kang L & 李桂楨(Guey-Jen L-C, 2013, In : Bio Formosa. 48, p. 17-26 10 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Carrier Proteins
polyglutamine

以amyloid-β聚集為目標的阿茲海默氏症治療策略

黃鉦翔(Chen-Hsiang H, 林志信, 李承榆(Cheng-Yu L, 簡虹琪(Hong-Chi C, 陳廷碩(Ting-Shou C, 李琦玫(Chi-Mei L & 李桂楨(Guey-Jen L-C, 2013, In : Bio Formosa. 48, p. 55-62 8 p.

Research output: Contribution to journalArticle

2012
4 Citations (Scopus)

ATXN8 -62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease

Chen, I. C., Wu, Y. R., Yang, S. J., Kao, S. H., Chen, Y. C., Chang, K. H., Lee, C. M., Lee, G-J. & Chen, C. M., 2012 Nov 1, In : European Journal of Neurology. 19, 11, p. 1462-1469 8 p.

Research output: Contribution to journalArticle

Parkinson Disease
Genotype
Trans-Activators
Chromatin Immunoprecipitation
Luciferases
37 Citations (Scopus)

Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an Intrahippocampal Lipopolysaccharide injection

Huang, H. J., Chen, Y. H., Liang, K. C., Jheng, Y. S., Jhao, J. J., Su, M-T., Lee, G-J. & Hsieh, H. M., 2012 Jul 23, In : PLoS One. 7, 7, e39656.

Research output: Contribution to journalArticle

Obese Mice
lipopolysaccharides
Lipopolysaccharides
injection
hyperglycemia
13 Citations (Scopus)

Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Chiang, H. L., Lee, G-J., Chen, C. M., Chen, Y. C., Lee, C. M., Liao, M. H. & Wu, Y. R., 2012 May 1, In : Parkinsonism and Related Disorders. 18, 4, p. 391-393 3 p.

Research output: Contribution to journalArticle

HLA-DR alpha-Chains
Parkinson Disease
Metagenomics
Genome-Wide Association Study
Neurodegenerative Diseases
5 Citations (Scopus)

LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations

Wu, Y. R., Tan, L. C., Fu, X., Chen, C. M., Au, W. L., Chen, L., Chen, Y. C., Prakash, K. M., Zheng, Y., Lee, G-J., Zhao, Y., Zeng, J. S., Tan, E. K. & Pei, Z., 2012 Jul 10, In : PLoS One. 7, 7, e36123.

Research output: Contribution to journalArticle

Parkinson disease
Taiwan
Parkinson Disease
risk factors
Population
4 Citations (Scopus)

Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population

Chen, Y. C., Chen, P., Wu, Y. R., Shie, S. S., Chen, S. T., Lee, G-J. & Chen, C. M., 2012 Oct 24, In : Neuroscience Letters. 528, 2, p. 170-173 4 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Taiwan
Protein Kinase C
Population
Stroke
18 Citations (Scopus)

Role of the CCAAT-binding protein NFY in SCA17 pathogenesis

Lee, L. C., Chen, C. M., Wang, H. C., Hsieh, H. H., Chiu, I. S., Su, M-T., Hsieh, H. M., Wu, C-H., Lee, G-C., Lee, G-J. & Lin, J. Y., 2012 Apr 17, In : PLoS One. 7, 4, e35302.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
TATA box
binding proteins
Carrier Proteins
Transcription Factors

Studies of Cap Independent Internal Ribosome Entry Segment Activity of ATXN8OS RNA

蕭欣杰(Hsin-Chieh S, 陳怡辰(I-Cheng C, 林玄原(Hsuan-Yuan L, 蘇銘燦(Ming-Tsan S & 李桂楨(Guey-Jen L-C, 2012, In : Bio Formosa. 47, p. 1-7 7 p.

Research output: Contribution to journalArticle

Ribosomes
Complementary DNA
RNA