• 1544 Citations
  • 20 h-Index
19992020

Research output per year

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Research Output

  • 1544 Citations
  • 20 h-Index
  • 45 Article
  • 3 Review article
2020

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Chung, Y. H., Lin, C. W., Huang, H. Y., Chen, S. L., Huang, H. J., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Chang, Y. C. & Hsieh-Li, H. M., 2020 Jan 1, (Accepted/In press) In : Journal of Molecular Neuroscience.

Research output: Contribution to journalArticle

2019

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Huang, H. J., Chen, S. L., Huang, H. Y., Sun, Y. C., Lee, G. C., Lee-Chen, G. J., Hsieh-Li, H. M. & Su, M. T., 2019 Feb 14, In : Psychopharmacology. 236, 2, p. 763-773 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2 Citations (Scopus)
2018

Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders

Chang, K. H., Lee, G. C., Huang, C. C., Kuo, H. C., Chen, C. M., Hsiao, Y. C., Hsu, H. C., Hsu, K. J., Lin, C. H., Chang, C. W., Lee-Chen, G. J. & Wu, Y. R., 2018 Jun, In : Parkinsonism and Related Disorders. 51, p. 61-66 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Hsu, C. J., Hsu, W. C., Lee, D. J., Liu, A. L., Chang, C. M., Shih, H. J., Huang, W. H., Lee-Chen, G. J., Hsieh-Li, H. M., Lee, G. C. & Sun, Y. C., 2017 Aug 1, In : Chemical Biology and Drug Design. 90, 2, p. 272-281 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The N253F mutant structure of trehalose synthase from Deinococcus radiodurans reveals an open active-site topology

Chow, S. Y., Wang, Y. L., Hsieh, Y. C., Lee, G. C. & Liaw, S. H., 2017 Nov, In : Acta Crystallographica Section F:Structural Biology Communications. 73, 11, p. 588-594 7 p.

Research output: Contribution to journalArticle

2016

Constitutive expression of recombinant human hyaluronidase PH20 by Pichia pastoris

Chen, K. J., Sabrina, S., El-Safory, N. S., Lee, G. C. & Lee, C. K., 2016 Dec 1, In : Journal of Bioscience and Bioengineering. 122, 6, p. 673-678 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays

Lin, C. H., Hsieh, Y. S., Wu, Y. R., Hsu, C. J., Chen, H. C., Huang, W. H., Chang, K. H., Hsieh-Li, H. M., Su, M. T., Sun, Y. C., Lee, G. C. & Lee-Chen, G. J., 2016 Jun 30, In : European Journal of Pharmaceutical Sciences. 89, p. 11-19 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia

Lin, C. H., Wu, Y. R., Yang, J. M., Chen, W. L., Chao, C. Y., Chen, I. C., Lin, T. H., Wu, Y. C., Hsu, K. C., Chen, C. M., Lee, G. C., Hsieh-Li, H. M., Lee, C. M. & Lee-Chen, G. J., 2016 Apr 1, In : CNS and Neurological Disorders - Drug Targets. 15, 3, p. 351-359 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

Conversion of crude Jatropha curcas seed oil into biodiesel using liquid recombinant Candida rugosa lipase isozymes

Kuo, T. C., Shaw, J. F. & Lee, G-C., 2015 Sep 1, In : Bioresource Technology. 192, p. 54-59 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Improvement in the secretory expression of recombinant Candida rugosa lipase in Pichia pastoris

Kuo, T. C., Shaw, J. F. & Lee, G. C., 2015 Dec 1, In : Process Biochemistry. 50, 12, p. 2137-2143 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 May 1, In : NeuroToxicology. 48, p. 120-130 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

Chen, Z. Z., Wang, C. M., Lee, G. C., Hsu, H. C., Wu, T. L., Lin, C. W., Ma, C. K., Lee-Chen, G. J., Huang, H. J. & Hsieh-Li, H. M., 2015 Jan 1, In : Neurochemical Research. 40, 4, p. 800-810 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Structures of trehalose synthase from Deinococcus radiodurans reveal that a closed conformation is involved in catalysis of the intramolecular isomerization

Wang, Y. L., Chow, S. Y., Lin, Y. T., Hsieh, Y. C., Lee, G. C. & Liaw, S. H., 2014 Dec 1, In : Acta Crystallographica Section D: Biological Crystallography. 70, 12, p. 3144-3154 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)

楊淑婷(Shu-Ting Y, 陳襄銘(Hsiang-Ming C, 李麗卿(Li-Ching L, 黃詩涵(Shih-Han H, 林志信(Chih-Hsin L, 李冠群(Guan-Chiun L, 李振綱(Cheng-Kang L & 李桂楨(Guey-Jen L-C, 2013, In : Bio Formosa. 48, p. 17-26 10 p.

Research output: Contribution to journalArticle

2012

Role of the CCAAT-binding protein NFY in SCA17 pathogenesis

Lee, L. C., Chen, C. M., Wang, H. C., Hsieh, H. H., Chiu, I. S., Su, M. T., Hsieh-Li, H. M., Wu, C. H., Lee, G. C., Lee-Chen, G. J. & Lin, J. Y., 2012 Apr 17, In : PloS one. 7, 4, e35302.

Research output: Contribution to journalArticle

21 Citations (Scopus)

建立高重組蛋白表達之酵母菌Pichia Pastoris系統

郭亭君(Ting-Chun K, 張瀞文(Jing-Wen C, 李振綱 & 李冠群(Guan-Chun L, 2012, In : Bio Formosa. 47, p. 43-49 7 p.

Research output: Contribution to journalArticle

2011

Characterization of codon-optimized recombinant Candida rugosa Lipase 5 (LIP5)

Lee, L. C., Yen, C. C., Malmis, C. C., Chen, L. F., Chen, J. C., Lee, G-C. & Shaw, J. F., 2011 Oct 12, In : Journal of Agricultural and Food Chemistry. 59, 19, p. 10693-10698 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Characterization of hyaluronate lyase from Streptococcus pyogenes bacteriophage H4489A

El-Safory, N. S., Lee, G. C. & Lee, C. K., 2011 Mar 17, In : Carbohydrate Polymers. 84, 3, p. 1182-1191 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
11 Citations (Scopus)
2010

Genes and biochemical characterization of three novel chlorophyllase isozymes from Brassica oleracea

Lee, G. C., Chepyshko, H., Chen, H. H., Chu, C. C., Chou, Y. F., Akoh, C. C. & Shaw, J. F., 2010 Aug 11, In : Journal of Agricultural and Food Chemistry. 58, 15, p. 8651-8657 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Site-directed mutagenesis improves the thermostability of a recombinant Picrophilus torridus trehalose synthase and efficiency for the production of trehalose from sweet potato starch

Chou, H. H., Chang, S. W., Lee, G. C., Chen, Y. S., Yeh, T., Akoh, C. C. & Shaw, J. F., 2010 Apr 1, In : Food Chemistry. 119, 3, p. 1017-1022 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
15 Citations (Scopus)
2009

Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis

Lee, L. C., Chen, C. M., Chen, F. L., Lin, P. Y., Hsiao, Y. C., Wang, P. R., Su, M. T., Hsieh-Li, H. M., Hwang, J. C., Wu, C. H., Lee, G. C., Singh, S., Lin, Y., Hsieh, S. Y., Lee-Chen, G. J. & Lin, J. Y., 2009 Feb 1, In : Clinica Chimica Acta. 400, 1-2, p. 56-62 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structure of the Alkalohyperthermophilic Archaeoglobus fulgidus Lipase Contains a Unique C-Terminal Domain Essential for Long-Chain Substrate Binding

Chen, C. K. M., Lee, G. C., Ko, T. P., Guo, R. T., Huang, L. M., Liu, H. J., Ho, Y. F., Shaw, J. F. & Wang, A. H. J., 2009 Jul 24, In : Journal of Molecular Biology. 390, 4, p. 672-685 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2008

Biocatalysis for the production of industrial products and functional foods from rice and other agricultural produce

Akoh, C. C., Chang, S. W., Lee, G-C. & Shaw, J. F., 2008 Nov 26, In : Journal of Agricultural and Food Chemistry. 56, 22, p. 10445-10451 7 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)

Promoter analysis and differential expression of the Candida rugosa lipase gene family in response to culture conditions

Hsu, K. H., Lee, G. C. & Shaw, J. F., 2008 Mar 26, In : Journal of Agricultural and Food Chemistry. 56, 6, p. 1992-1998 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2007

Altering the substrate specificity of Candida rugosa LIP4 by engineering the substrate-binding sites

Lee, L. C., Chen, Y. T., Yen, C. C., Chiang, T. C. Y., Tang, S. J., Lee, G-C. & Shaw, J. F., 2007 Jun 27, In : Journal of Agricultural and Food Chemistry. 55, 13, p. 5103-5108 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Construction of a recombinant thermostable β-amylase-trehalose synthase bifunctional enzyme for facilitating the conversion of starch to trehalose

Wang, J. H., Tsai, M. Y., Lee, G. C. & Shaw, J. F., 2007 Feb 21, In : Journal of Agricultural and Food Chemistry. 55, 4, p. 1256-1263 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Enzymatic approach to biodiesel production

Akoh, C. C., Chang, S. W., Lee, G. C. & Shaw, J. F., 2007 Oct 31, In : Journal of Agricultural and Food Chemistry. 55, 22, p. 8995-9005 11 p.

Research output: Contribution to journalArticle

254 Citations (Scopus)

Gene cloning and characterization of a novel recombinant antifungal chitinase from papaya (carica papaya)

Chen, Y. T., Hsu, L. H., Huang, I. P., Tsai, T. C., Lee, G. C. & Shaw, J. F., 2007 Feb 7, In : Journal of Agricultural and Food Chemistry. 55, 3, p. 714-722 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Role of the C-terminal domain of Thermus thermophilus trehalose synthase in the thermophilicity, thermostability, and efficient production of trehalose

Wang, J. H., Tsai, M. Y., Chen, J. J., Lee, G. C. & Shaw, J. F., 2007 May 2, In : Journal of Agricultural and Food Chemistry. 55, 9, p. 3435-3443 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Synthesis and characterization of canola oil-stearic acid-based trans-free structured lipids for possible margarine application

Lumor, S. E., Jones, K. C., Ashby, R., Strahan, G. D., Byung, H. K., Lee, G-C., Shaw, J. F., Kays, S. E., Chang, S. W., Foglia, T. A. & Akoh, C. C., 2007 Dec 26, In : Journal of Agricultural and Food Chemistry. 55, 26, p. 10692-10702 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2006

Candida rugosa lipase LIP1-catalyzed transesterification to produce human milk fat substitute

Srivastava, A., Akoh, C. C., Chang, S. W., Lee, G. C. & Shaw, J. F., 2006 Jul 12, In : Journal of Agricultural and Food Chemistry. 54, 14, p. 5175-5181 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
68 Citations (Scopus)
29 Citations (Scopus)
55 Citations (Scopus)

Optimized growth kinetics of Pichia pastoris and recombinant Candida rugosa LIP1 production by RSM

Chang, S. W., Shieh, C. J., Lee, G-C., Akoh, C. C. & Shaw, J. F., 2006 Jul 1, In : Journal of Molecular Microbiology and Biotechnology. 11, 1-2, p. 28-40 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2005

Multiple mutagenesis of the Candida rugosa LIP1 gene and optimum production of recombinant LIP1 expressed in Pichia pastoris

Chang, S. W., Shieh, C. J., Lee, G-C. & Shaw, J. F., 2005 Apr 1, In : Applied Microbiology and Biotechnology. 67, 2, p. 215-224 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2004

GDSL family of serine esterases/lipases

Akoh, C. C., Lee, G. C., Liaw, Y. C., Huang, T. H. & Shaw, J. F., 2004 Nov 1, In : Progress in Lipid Research. 43, 6, p. 534-552 19 p.

Research output: Contribution to journalReview article

337 Citations (Scopus)

Lipase-catalyzed alcoholysis of triglycerides for short-chain monoglyceride production

Lee, G. C., Wang, D. L., Ho, Y. F. & Shaw, J. F., 2004 Jun, In : JAOCS, Journal of the American Oil Chemists' Society. 81, 6, p. 533-536 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Protein engineering and applications of Candida rugosa lipase isoforms

Akoh, C. C., Lee, G. C. & Shaw, J. F., 2004 Jun 1, In : Lipids. 39, 6, p. 513-526 14 p.

Research output: Contribution to journalReview article

88 Citations (Scopus)
2003

A transformation system for the nonuniversal CUGSer codon usage species Candida rugosa

Tang, S. J., Sun, K. H., Sun, G. H., Chang, T. Y., Wu, W. L. & Lee, G. C., 2003 Feb 1, In : Journal of Microbiological Methods. 52, 2, p. 231-238 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2002

Factors affecting the resolution of dl-menthol by immobilized lipase-catalyzed esterification in organic solvent

Wang, D. L., Nag, A., Lee, G-C. & Shaw, J. F., 2002 Jan 16, In : Journal of Agricultural and Food Chemistry. 50, 2, p. 262-265 4 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
40 Citations (Scopus)
2001

Recombinant expression and characterization of the Candida rugosa lip4 lipase in Pichia pastoris: Comparison of glycosylation, activity, and stability

Tang, S. J., Shaw, J. F., Sun, K. H., Sun, G. H., Chang, T. Y., Lin, C. K., Lo, Y. C. & Lee, G. C., 2001 Mar 1, In : Archives of Biochemistry and Biophysics. 387, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2000

Recombinant expression of the Candida rugosa lip4 lipase in Escherichia coli

Tang, S. J., Sun, K. H., Sun, G. H., Chang, T. Y. & Lee, G-C., 2000 Jan 1, In : Protein Expression and Purification. 20, 2, p. 308-313 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
1999

Analysis of the gene family encoding lipases in Candida rugosa by competitive reverse transcription-PCR

Lee, G. C., Tang, S. J., Sun, K. H. & Shaw, J. F., 1999 Sep, In : Applied and Environmental Microbiology. 65, 9, p. 3888-3895 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)