• 4098 Citations
  • 35 h-Index
1988 …2019
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Research Output 1988 2019

2019
2 Citations (Scopus)

Aromatherapy: Activating olfactory calcium-sensing receptors impairs renal hemodynamics via sympathetic nerve-mediated vasoconstriction

Lee, S. P., Wu, W. Y., Hsiao, J. K., Zhou, J. H., Chang, H. H. & Chien, C. T., 2019 Jan 1, In : Acta Physiologica. 225, 1, e13157.

Research output: Contribution to journalArticle

Aromatherapy
Calcium-Sensing Receptors
Vasoconstriction
Olfactory Receptor Neurons
Hemodynamics
4 Citations (Scopus)

Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryos

Hung, G. Y., Wu, C. L., Chou, Y. L., Chien, C. T., Horng, J. L. & Lin, L. Y., 2019 Apr 1, In : Aquatic Toxicology. 209, p. 168-177 10 p.

Research output: Contribution to journalArticle

cisplatin
Zebrafish
Danio rerio
hair
skin (animal)
2018
3 Citations (Scopus)
Open Access
Catechin
Oxidative Stress
Nitric Oxide Synthase Type III
8-epi-prostaglandin F2alpha
Endothelial Cells
2 Citations (Scopus)

Genetic Depletion of Thromboxane A 2 /Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury

Chiang, C. Y., Chien, C. Y., Qiou, W. Y., Chang, C., Yu, I. S., Chang, P. Y. & Chien, C. T., 2018 Jan 1, In : Thrombosis and Haemostasis. 118, 11, p. 1982-1996 15 p.

Research output: Contribution to journalArticle

Thromboxane Receptors
Thromboxanes
Thromboxane-A Synthase
Reperfusion Injury
varespladib methyl
2 Citations (Scopus)

I-Tiao-Gung extract through its active component daidzin improves cyclophosphamide-induced bladder dysfunction in rat model

Wu, K. C., Chiang, B. J., Tsai, W. H., Chung, S. D. & Chien, C. T., 2018 Nov 1, In : Neurourology and Urodynamics. 37, 8, p. 2560-2570 11 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Urinary Bladder
Cystitis
daidzin
Electromyography
2017
18 Citations (Scopus)
Antrodia
Diethylnitrosamine
Carcinogenesis
Fibrosis
Inflammation
9 Citations (Scopus)
Autophagy
Intercellular Adhesion Molecule-1
Substance P
Urinary Bladder
Apoptosis
1 Citation (Scopus)

Synthetic nickel-containing superoxide dismutase attenuates para-phenylenediamine-induced bladder dysfunction in rats

Chiang, B. J., Chen, T. W., Chung, S. D., Lee, W. Z. & Chien, C. T., 2017 Nov 11, In : Oncotarget. 8, 62, p. 105735-105748 14 p.

Research output: Contribution to journalArticle

Nickel
Superoxide Dismutase
Urinary Bladder
Autophagy
Phenylenediamines
2016
7 Citations (Scopus)
Intercellular Adhesion Molecule-1
Substance P
Urinary Bladder
Reactive Oxygen Species
Neurokinin-1 Receptors
14 Citations (Scopus)
Open Access
Epithelial-Mesenchymal Transition
Macrophages
Cisplatin
Fibrosis
Epithelial Cells
2 Citations (Scopus)

Monascus Adlay and Monacolin K Attenuates Arterial Thrombosis in Rats through the Inhibition of ICAM-1 and Oxidative Stress

Tien, A. J., Chueh, T. H., Hsia, C. P. & Chien, C. T., 2016 Dec 1, In : Kidney and Blood Pressure Research. 41, 6, p. 815-827 13 p.

Research output: Contribution to journalArticle

Monascus
Lovastatin
Intercellular Adhesion Molecule-1
Oxidative Stress
Thrombosis
7 Citations (Scopus)

Predicting stroke volume and arterial pressure fluid responsiveness in liver cirrhosis patients using dynamic preload variables

Wu, C. Y., Cheng, Y. J., Liu, Y. J., Wu, T. T., Chien, C. T. & Chan, K. C., 2016 Sep 1, In : European Journal of Anaesthesiology. 33, 9, p. 645-652 8 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Stroke Volume
Arterial Pressure
Blood Pressure
Blood Vessels
10 Citations (Scopus)
Open Access
Toll-Like Receptor 4
N-Acetylneuraminic Acid
Acute Kidney Injury
Lipopolysaccharides
Kidney
22 Citations (Scopus)
Psidium
Trehalose
Quercetin
Autophagy
Rats
4 Citations (Scopus)

Soy-based multiple amino acid oral supplementation increases the anti-sarcoma effect of cyclophosphamide

Yao, C. A., Chen, C. C., Wang, N. P. & Chien, C. T., 2016 Apr 1, In : Nutrients. 8, 4, 192.

Research output: Contribution to journalArticle

cyclophosphamide
sarcoma
Sarcoma
Cyclophosphamide
mouth
13 Citations (Scopus)

Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis

Chang, H. H., Chang, Y. K., Lu, C. W., Huang, C. T., Chien, C. T., Hung, K. Y., Huang, K. C. & Hsu, C. C., 2016 Feb 23, In : Scientific Reports. 6, 22197.

Research output: Contribution to journalArticle

Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Arteriovenous Fistula
Renal Dialysis
Recreation
Risk Reduction Behavior
4 Citations (Scopus)
Endoplasmic Reticulum Stress
Autophagy
Urinary Bladder
Down-Regulation
Ischemia
2015
1 Citation (Scopus)

Design of complementary tilt-gate TFETs with SiGe/Si and III-V integrations feasible for ultra-low-power applications

Hsieh, E. R., Lin, Y. S., Zhao, Y. B., Liu, C. H., Chien, C. H. & Chung, S. S., 2015 Sep 24, 2015 Silicon Nanoelectronics Workshop, SNW 2015. Institute of Electrical and Electronics Engineers Inc., 7275322. (2015 Silicon Nanoelectronics Workshop, SNW 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Static random access storage
Electric fields
Substrates
6 Citations (Scopus)

Effect of adenoviral catalase gene transfer on renal ischemia/reperfusion injury in rats

Yang, C. C., Hsu, S. P., Chen, K. H. & Chien, C. T., 2015 Jan 1, In : Chinese Journal of Physiology. 58, 6, p. 420-430 11 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Catalase
Kidney
Nitric Oxide
Genes
26 Citations (Scopus)

Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation

The NTUH Center of Microcirculation Medical Research (NCMMR), 2015 Dec 11, In : Critical Care. 19, 1, 434.

Research output: Contribution to journalArticle

Viscera
Hemorrhagic Shock
Microcirculation
Resuscitation
Reactive Oxygen Species
19 Citations (Scopus)
Neurologic Manifestations
Reperfusion Injury
Brain Ischemia
Microspheres
Carotid Arteries
11 Citations (Scopus)

Laser speckle contrast imaging for assessing microcirculatory changes in multiple splanchnic organs and the gracilis muscle during hemorrhagic shock and fluid resuscitation

on behalf of the NTUH Center of Microcirculation Medical Research (NCMMR), 2015 Sep 1, In : Microvascular Research. 101, p. 55-61 7 p.

Research output: Contribution to journalArticle

Resuscitation
Viscera
Hemorrhagic Shock
Speckle
Muscle
1 Citation (Scopus)

Oral treatment with herbal formula B401 alleviates penile toxicity in aging mice with manganism

Hsu, C. H., Lin, C. L., Wang, S. E., Sheu, S. J., Chien, C. T. & Wu, C. H., 2015 May 28, In : Clinical Interventions in Aging. 10, p. 907-918 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Manganese
Apoptosis
Inflammation
B-Cell Lymphoma
7 Citations (Scopus)

Oral treatment with the herbal formula B307 alleviates cardiac toxicity in doxorubicin-treated mice via suppressing oxidative stress, inflammation, and apoptosis

Lien, C. Y., Chuang, T. Y., Hsu, C. H., Lin, C. L., Wang, S. E., Sheu, S. J., Chien, C. T. & Wu, C. H., 2015 Jan 1, In : OncoTargets and Therapy. 8, p. 1193-1210 18 p.

Research output: Contribution to journalArticle

Doxorubicin
Oxidative Stress
Apoptosis
Inflammation
Therapeutics
6 Citations (Scopus)

Treatment with a herbal formula B401 enhances neuroprotection and angiogenesis in the R6/2 mouse model of Huntington’s disease

Wang, S. E., Lin, C. L., Hsu, C. H., Sheu, S. J., Chien, C. T. & Wu, C. H., 2015 Feb 16, In : Drug Design, Development and Therapy. 9, p. 887-900 14 p.

Research output: Contribution to journalArticle

Huntington Disease
Therapeutics
Encephalitis
Neurodegenerative Diseases
B401 herbal formula
2014
7 Citations (Scopus)

Deep-sea water containing selenium provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1

Yang, C. C., Yao, C. A., Lin, Y. R., Yang, J. C. & Chien, C. T., 2014 Jul 1, In : PloS one. 9, 7, e96006.

Research output: Contribution to journalArticle

Thioredoxin Reductase 1
duodenal ulcers
Seawater
Duodenal Ulcer
Selenium
4 Citations (Scopus)

Prediction of severe neonatal hyperbilirubinemia using cord blood hydrogen peroxide: A prospective study

Chou, H. C., Chien, C. T., Tsao, P. N., Hsieh, W. S., Chen, C. Y. & Chang, M. H., 2014 Jan 23, In : PloS one. 9, 1, e86797.

Research output: Contribution to journalArticle

Neonatal Hyperbilirubinemia
hyperbilirubinemia
prospective studies
Fetal Blood
Hydrogen Peroxide
14 Citations (Scopus)
Reperfusion Injury
Mitochondria
Antioxidants
Hot Temperature
Endoplasmic Reticulum Stress
28 Citations (Scopus)

Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress

Yu, C. J., Ko, C. J., Hsieh, C. H., Chien, C. T., Huang, L. H., Lee, C. W. & Jiang, C. C., 2014 Mar 17, In : Journal of Proteomics. 99, p. 40-53 14 p.

Research output: Contribution to journalArticle

Oxidative stress
Hyaluronic Acid
Chondrocytes
Osteoarthritis
Proteomics
32 Citations (Scopus)
Toll-Like Receptor 4
Endoplasmic Reticulum Stress
Autophagy
N-Acetylneuraminic Acid
Acute Kidney Injury
2013
6 Citations (Scopus)

Alterations in peripheral purinergic and muscarinic signaling of rat bladder after long-term fructose-induced metabolic syndrome

Chung, S. D., Chien, C. T. & Yu, H. J., 2013 Feb 1, In : European Journal of Nutrition. 52, 1, p. 347-359 13 p.

Research output: Contribution to journalArticle

Fructose
Cholinergic Agents
Urinary Bladder
Cholinergic Receptors
Muscarinic Receptors
4 Citations (Scopus)

Augmented renal prostacyclin by intrarenal bicistronic cyclo-oxygenase-1/ Prostacyclin synthase gene transfer attenuates renal ischemia-reperfusion injury

Yang, C. C., Chen, K. H., Hsu, S. P. & Chien, C. T., 2013 Dec 27, In : Transplantation. 96, 12, p. 1043-1051 9 p.

Research output: Contribution to journalArticle

Epoprostenol
Prostaglandin-Endoperoxide Synthases
Reperfusion Injury
Coat Protein Complex I
Kidney
21 Citations (Scopus)

Catechins and sialic acid attenuate helicobacter pylori -triggered epithelial caspase-1 activity and eradicate helicobacter pylori infection

Yang, J. C., Yang, H. C., Shun, C. T., Wang, T. H., Chien, C. T. & Kao, J. Y., 2013 May 13, In : Evidence-based Complementary and Alternative Medicine. 2013, 248585.

Research output: Contribution to journalArticle

Caspase 1
Catechin
Helicobacter Infections
N-Acetylneuraminic Acid
Helicobacter pylori
6 Citations (Scopus)
Monascus
Coix lacryma-jobi
Endoplasmic Reticulum Stress
autophagy
cigarettes
61 Citations (Scopus)

Electrospun scaffolds composing of alginate, chitosan, collagen and hydroxyapatite for applying in bone tissue engineering

Yu, C. C., Chang, J. J., Lee, Y. H., Lin, Y. C., Wu, M. H., Yang, M. C. & Chien, C. T., 2013 Jan 7, In : Materials Letters. 93, p. 133-136 4 p.

Research output: Contribution to journalArticle

tissue engineering
Alginate
Chitosan
Durapatite
collagens
16 Citations (Scopus)

Glucagon-like peptide-1 receptor agonist activation ameliorates venous thrombosis- induced arteriovenous fistula failure in chronic kidney d isease

Chien, C. T., Fan, S. C., Lin, S. C., Kuo, C. C., Yang, C. H., Yu, T. Y., Lee, S. P., Cheng, D. Y. & Li, P. C., 2013 Nov 1, In : Thrombosis and Haemostasis. 112, 5, p. 1051-1064 14 p.

Research output: Contribution to journalArticle

Arteriovenous Fistula
Chronic Renal Insufficiency
Venous Thrombosis
Chronic Kidney Failure
Thromboxane A2
17 Citations (Scopus)

Therapeutic potential of traditional chinese medicine on inflammatory diseases

Tsai, W. H., Yang, C. C., Li, P. C., Chen, W. C. & Chien, C. T., 2013 Jan 1, In : Journal of Traditional and Complementary Medicine. 3, 3, p. 142-151 10 p.

Research output: Contribution to journalReview article

Chinese Traditional Medicine
Inflammation
Phyllanthus emblica
Monascus
Liver
2012
51 Citations (Scopus)

Acceleration of wound healing in diabetic rats by layered hydrogel dressing

Lee, Y. H., Chang, J. J., Yang, M. C., Chien, C. T. & Lai, W. F., 2012 Apr 15, In : Carbohydrate Polymers. 88, 3, p. 809-819 11 p.

Research output: Contribution to journalArticle

Hydrogel
Alginate
Hydrogels
Rats
Chitosan
57 Citations (Scopus)

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

Chung, S. D., Lai, T. Y., Chien, C. T. & Yu, H. J., 2012 Oct 10, In : PloS one. 7, 10, e47299.

Research output: Contribution to journalArticle

Ureteral Obstruction
autophagy
Autophagy
Oxidative stress
apoptosis
34 Citations (Scopus)

Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats

Lee, Y. H., Chang, J. J., Chien, C. T., Yang, M. C. & Chien, H. F., 2012 Sep 18, In : Experimental Diabetes Research. 2012, 504693.

Research output: Contribution to journalArticle

UCON 50-HB-5100
Poloxamer
Polymethyl Methacrylate
Streptozocin
Wound Healing
35 Citations (Scopus)

Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

Chang, J. J., Lee, Y. H., Wu, M. H., Yang, M. C. & Chien, C. T., 2012 May 16, In : Carbohydrate Polymers. 88, 4, p. 1304-1312 9 p.

Research output: Contribution to journalArticle

Alginate
Chitosan
Adhesion
Disintegration
Tissue
11 Citations (Scopus)

Green tea extract supplementation ameliorates CCl4-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat

Hung, G. D., Li, P. C., Lee, H. S., Chang, H. M., Chien, C. T. & Lee, K. L., 2012 Oct 1, In : Journal of the Formosan Medical Association. 111, 10, p. 550-559 10 p.

Research output: Contribution to journalArticle

Acute-Phase Proteins
Tea
Oxidative Stress
Fibrosis
Liver
4 Citations (Scopus)

Inhibitory effect of botulinum toxin type A on the NANC system in rat respiratory models of neurogenic inflammation

Chien, C-T., Lee, H. M., Wu, C. C. & Li, P. C., 2012 Aug 15, In : Archives of Biochemistry and Biophysics. 524, 2, p. 106-113 8 p.

Research output: Contribution to journalArticle

Neurogenic Inflammation
Type A Botulinum Toxins
Rats
Cerebral Arteries
Synaptosomal-Associated Protein 25
39 Citations (Scopus)

Preparation of electrospun alginate fibers with chitosan sheath

Chang, J. J., Lee, Y. H., Wu, M. H., Yang, M. C. & Chien, C-T., 2012 Feb 14, In : Carbohydrate Polymers. 87, 3, p. 2357-2361 5 p.

Research output: Contribution to journalArticle

Alginate
Chitosan
Fibers
Scanning
alginic acid
11 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Nitric Oxide Synthase Type III
Heat-Shock Proteins
Thrombosis
Hot Temperature
2011
20 Citations (Scopus)

Cordyceps sobolifera extract ameliorates lipopolysaccharide-induced renal dysfunction in the rat

Wu, M. F., Li, P. C., Chen, C. C., Ye, S. S., Chien, C. T. & Yu, C. C., 2011 May 30, In : American Journal of Chinese Medicine. 39, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

Cordyceps
Lipopolysaccharides
Kidney
Autophagy
Apoptosis
49 Citations (Scopus)

DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity

Wu, P. R., Tsai, P. I., Chen, G. C., Chou, H. J., Huang, Y. P., Chen, Y. H., Lin, M. Y., Kimchi, A., Chien, C-T. & Chen, R. H., 2011 Sep 1, In : Cell Death and Differentiation. 18, 9, p. 1507-1520 14 p.

Research output: Contribution to journalArticle

Death-Associated Protein Kinases
Microtubules
Phosphorylation
Drosophila
Alzheimer Disease
28 Citations (Scopus)

Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver

Chen, K. H., Li, P. C., Lin, W. H., Chien, C. T. & Low, B. H., 2011 Sep 29, In : Bioscience, Biotechnology and Biochemistry. 75, 9, p. 1668-1676 9 p.

Research output: Contribution to journalArticle

Lipogenesis
Oxidative stress
Tea
Liver
Rats
17 Citations (Scopus)

Emblica officinalis gaertn. attentuates N-nitrosodiethylamine-induced apoptosis, autophagy, and inflammation in rat livers

Chen, K. H., Lin, B. R., Chien, C-T. & Ho, C. H., 2011 Jul 1, In : Journal of Medicinal Food. 14, 7-8, p. 746-755 10 p.

Research output: Contribution to journalArticle

Phyllanthus emblica
Diethylnitrosamine
Autophagy
Apoptosis
Inflammation
7 Citations (Scopus)
Intercellular Adhesion Molecule-1
Oxidation-Reduction
Blood Vessels
Down-Regulation
Water