• 602 Citations
  • 15 h-Index
1992 …2019
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Research Output 1992 2019

  • 602 Citations
  • 15 h-Index
  • 48 Article
  • 1 Conference article
2019

Indole compound NC009-1 augments APOE and TRKA in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement

Chen, Y. C., Chiu, Y. J., Lin, C. H., Hsu, W. C., Wu, J. L., Huang, C. H., Lin, C. W., Yao, C. F., Huang, H. J., Lo, Y. S., Chen, C. M., Wu, Y. R., Chang, K. H., Lee-Chen, G. J. & Hsieh-Li, H. M., 2019 Jan 1, In : Journal of Alzheimer's Disease. 67, 2, p. 737-756 20 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Alzheimer Disease
Biomarkers
Leukocytes
Down-Regulation
Alzheimer Disease
Inflammation
Green Fluorescent Proteins
p38 Mitogen-Activated Protein Kinases
Acetylcholinesterase
1 Citation (Scopus)

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Lee, M. C., Chen, I. C., Lin, C. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Hsieh-Li, H. M. & Lee-Chen, G. J., 2019 Jan 1, In : Aging. 11, 3, p. 986-1007 22 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
GATA1 Transcription Factor
Medicine
Glycyrrhiza uralensis
Paeonia

Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3

Chen, I. C., Chang, C. N., Chen, W. L., Lin, T. H., Chao, C. Y., Lin, C. H., Lin, H. Y., Cheng, M. L., Chiang, M. C., Lin, J. Y., Wu, Y. R., Lee-Chen, G. J. & Chen, C. M., 2019 Jan 1, In : American Journal of Chinese Medicine. 47, 1, p. 63-95 33 p.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Chinese Traditional Medicine
Proteasome Endopeptidase Complex
Ubiquitin
Spinocerebellar Ataxias
2018

Chinese Herbal Medicine Glycyrrhiza inflata Reduces Aβ Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation

Chiu, Y. J., Lee, C. M., Lin, T. H., Lin, H. Y., Lee, S. Y., Mesri, M., Chang, K. H., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2018 Jan 1, In : American Journal of Chinese Medicine. 46, 7, p. 1535-1549 15 p.

Research output: Contribution to journalArticle

Glycyrrhiza
Herbal Medicine
Amyloid
Apoptosis
Inflammation
2 Citations (Scopus)

Formulated Chinese medicine shaoyao gancao tang reduces tau aggregation and exerts neuroprotection through anti-oxidation and anti-inflammation

Chen, I. C., Lin, T. H., Hsieh, Y. H., Chao, C. Y., Wu, Y. R., Chang, K. H., Lee, M. C., Lee-Chen, G. J. & Chen, C. M., 2018 Jan 1, In : Oxidative Medicine and Cellular Longevity. 2018, 9595741.

Research output: Contribution to journalArticle

Open Access
Glycyrrhiza uralensis
Medicine
Anti-Inflammatory Agents
Agglomeration
Inflammation
1 Citation (Scopus)

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

Chang, K. H., Lee-Chen, G. J., Huang, C. C., Lin, J. L., Chen, Y. J., Wei, P. C., Lo, Y. S., Yao, C. F., Kuo, M. W. & Chen, C. M., 2018 Jan 1, (Accepted/In press) In : Molecular Neurobiology. 56, 6, p. 3972-3983 12 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Alzheimer Disease
Mutation
Neurons
Caspase 1
4 Citations (Scopus)

The indole compound NC009-1 inhibits aggregation and promotes neurite outgrowth through enhancement of HSPB1 in SCA17 cells and ameliorates the behavioral deficits in SCA17 mice

Chen, C. M., Chen, W. L., Hung, C. T., Lin, T. H., Chao, C. Y., Lin, C. H., Wu, Y. R., Chang, K. H., Yao, C. F., Lee-Chen, G. J., Su, M. T. & Hsieh-Li, H. M., 2018 Jul 1, In : NeuroToxicology. 67, p. 259-269 11 p.

Research output: Contribution to journalArticle

TATA-Box Binding Protein
Agglomeration
Molecular Chaperones
Gene encoding
indole
2017

Synchronization and inter-layer interactions of noise-driven neural networks

Yuniati, A., Mai, T. L. & Chen, C-M., 2017 Jan 31, In : Frontiers in Computational Neuroscience. 11, 2.

Research output: Contribution to journalArticle

Noise
Neurons
Learning
5 Citations (Scopus)

Visualizing the GPCR Network: Classification and Evolution

Hu, G. M., Mai, T. L. & Chen, C-M., 2017 Dec 1, In : Scientific Reports. 7, 1, 15495.

Research output: Contribution to journalArticle

Proteins
Peptides
Clustering algorithms
2016
8 Citations (Scopus)

Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan

Chen, C. M., Chen, Y. C., Chiang, M. C., Fung, H. C., Chang, K. H., Lee-Chen, G. J. & Wu, Y. R., 2016 Mar 1, In : Neurobiology of Aging. 39, p. 221.e1-221.e5

Research output: Contribution to journalArticle

Taiwan
Parkinson Disease
Genome-Wide Association Study
Odds Ratio
Genetic Loci
8 Citations (Scopus)

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Chang, K. H., Chen, I. C., Lin, H. Y., Chen, H. C., Lin, C. H., Lin, T. H., Weng, Y. T., Chao, C. Y., Wu, Y. R., Lin, J. Y., Lee-Chen, G. J. & Chen, C. M., 2016 Feb 29, In : Drug Design, Development and Therapy. 10, p. 885-896 12 p.

Research output: Contribution to journalArticle

Open Access
Glycyrrhiza
Unfolded Protein Response
Tauopathies
Alzheimer Disease
Up-Regulation
6 Citations (Scopus)

Visualizing and Clustering Protein Similarity Networks: Sequences, Structures, and Functions

Mai, T. L., Hu, G. M. & Chen, C-M., 2016 Jul 1, In : Journal of Proteome Research. 15, 7, p. 2123-2131 9 p.

Research output: Contribution to journalArticle

Cluster Analysis
Proteins
Enzymes
Protein Databases
Molecular Evolution
6 Citations (Scopus)

Visualizing the world's scientific publications

Chen, R. H. G. & Chen, C-M., 2016 Oct 1, In : Journal of the Association for Information Science and Technology. 67, 10, p. 2477-2488 12 p.

Research output: Contribution to journalArticle

Economics
Visualization
Group
knowledge production
specialization
2015
4 Citations (Scopus)

Clustering and visualizing similarity networks of membrane proteins

Hu, G. M., Mai, T. L. & Chen, C-M., 2015 Aug 1, In : Proteins: Structure, Function and Bioinformatics. 83, 8, p. 1450-1461 12 p.

Research output: Contribution to journalArticle

Cluster Analysis
Membrane Proteins
7 Citations (Scopus)

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment

Lee, G. C., Lin, C. H., Tao, Y. C., Yang, J. M., Hsu, K. C., Huang, Y. J., Huang, S. H., Kung, P. J., Chen, W. L., Wang, C. M., Wu, Y. R., Chen, C. M., Lin, J. Y., Hsieh-Li, H. M. & Lee-Chen, G. J., 2015 May 1, In : NeuroToxicology. 48, p. 120-130 11 p.

Research output: Contribution to journalArticle

Melibiose
Trehalase
Neurodegenerative diseases
Lactulose
Trehalose
2014
6 Citations (Scopus)

Computational prediction of kink properties of helices in membrane proteins

Mai, T. L. & Chen, C-M., 2014 Jan 1, In : Journal of Computer-Aided Molecular Design. 28, 2, p. 99-109 11 p.

Research output: Contribution to journalArticle

helices
Heating
Industrial heating
Membrane Proteins
membranes
2012

Monte Carlo simulations of single and coupled synthetic molecular motors

Chen, C-M. & Zuckermann, M., 2012 Nov 5, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 86, 5, 051905.

Research output: Contribution to journalArticle

Molecular Motor
Monte Carlo Simulation
Salsola
Ligands
simulation
6 Citations (Scopus)

Replica exchange Monte-Carlo simulations of helix bundle membrane proteins: Rotational parameters of helices

Wu, H. H., Chen, C. C. & Chen, C-M., 2012 Mar 1, In : Journal of Computer-Aided Molecular Design. 26, 3, p. 363-374 12 p.

Research output: Contribution to journalArticle

replicas
Halorhodopsins
helices
bundles
Membrane Proteins
9 Citations (Scopus)

Statistical analyses and computational prediction of helical kinks in membrane proteins

Huang, Y. H. & Chen, C-M., 2012 Oct 1, In : Journal of Computer-Aided Molecular Design. 26, 10, p. 1171-1185 15 p.

Research output: Contribution to journalArticle

Proline
helices
Membrane Proteins
membranes
proteins
2011
16 Citations (Scopus)
Social sciences
visualization
Visualization
social science
Network components
3 Citations (Scopus)

Synchronization in a noise-driven developing neural network

Lin, I. H., Wu, R. K. & Chen, C-M., 2011 Nov 29, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 84, 5, 051923.

Research output: Contribution to journalArticle

Noise
synchronism
Synchronization
Neural Networks
Neurons
2009
8 Citations (Scopus)

A dual-scale approach toward structure prediction of retinal proteins

Chen, C. C. & Chen, C-M., 2009 Jan 1, In : Journal of Structural Biology. 165, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Sensory Rhodopsins
Halorhodopsins
Bacteriorhodopsins
Rhodopsin
Molecular Dynamics Simulation
1 Citation (Scopus)

Effects of Si capping layers on the properties of ultrathin Co/Ir(111) films

Tsay, J-S., Liou, Y. C., Chen, C-M. & Chan, W. Y., 2009 Nov 16, In : Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films. 27, 6, p. 1266-1270 5 p.

Research output: Contribution to journalArticle

Annealing
Magnetic hysteresis
Adatoms
Low energy electron diffraction
Silicon
2008
15 Citations (Scopus)
Values
Citations
Classification schemes
Data base
Specificity
8 Citations (Scopus)

Packing of transmembrane helices in bacteriorhodopsin folding: Structure and thermodynamics

Chen, C. C., Wei, C. C., Sun, Y-C. & Chen, C-M., 2008 May 1, In : Journal of Structural Biology. 162, 2, p. 237-247 11 p.

Research output: Contribution to journalArticle

Bacteriorhodopsins
Thermodynamics
Amber
Computer Simulation
Membrane Proteins
2007
4 Citations (Scopus)

Contact-induced structure transformation in transmembrane prion propagation

Ou, D. M., Chen, C. C. & Chen, C-M., 2007 Jan 1, In : Biophysical Journal. 92, 8, p. 2704-2710 7 p.

Research output: Contribution to journalArticle

Prions
Dimerization
Prion Diseases
Scrapie
Computer Simulation
7 Citations (Scopus)
Nanopores
polynucleotides
Polynucleotides
Time series
Polymers
2006
26 Citations (Scopus)

Visualizing the scientific world and its evolution

Samoylenko, I., Chao, T. C., Liu, W-C. & Chen, C-M., 2006 Sep 1, In : Journal of the American Society for Information Science and Technology. 57, 11, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

science
scientific journal
life sciences
level of knowledge
Sorting
2005
21 Citations (Scopus)
polynucleotides
Nanopore
Translocation
Monte Carlo Simulation
sequencing
10 Citations (Scopus)

Learning-induced synchronization and plasticity of a developing neural network

Chao, T. C. & Chen, C-M., 2005 Dec 1, In : Journal of Computational Neuroscience. 19, 3, p. 311-324 14 p.

Research output: Contribution to journalArticle

Learning
Neuronal Plasticity
Behavior Control
Neural Networks (Computer)
Computer Simulation
2003
26 Citations (Scopus)

Computer simulations of membrane protein folding: Structure and dynamics

Chen, C-M. & Chen, C. C., 2003 Mar 1, In : Biophysical Journal. 84, 3, p. 1902-1908 7 p.

Research output: Contribution to journalArticle

Protein Folding
Computer Simulation
Membrane Proteins
Sensory Rhodopsins
21 Citations (Scopus)

Nanopore sequencing of polynucleotides assisted by a rotating electric field

Chen, C. M. & Peng, E. H., 2003 Feb 24, In : Applied Physics Letters. 82, 8, p. 1308-1310 3 p.

Research output: Contribution to journalArticle

polynucleotides
sequencing
electric fields
nucleotides
electric charge
2001
2 Citations (Scopus)

Instability of myelin tubes under dehydration: Deswelling of layered cylindrical structures

Chen, C-M., Schmidt, C. F., Olmsted, P. D. & MacKintosh, F. C., 2001 Jan 1, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 64, 5 I, p. 050903/1-050903/4 050903.

Research output: Contribution to journalArticle

myelin
Myelin Sheath
Surface area
Dehydration
dehydration
15 Citations (Scopus)

Lattice model of transmembrane polypeptide folding

Chen, C-M., 2001 Dec 1, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 63, 1 I, p. 109011-109014 4 p., 010901.

Research output: Contribution to journalArticle

polypeptides
Folding
Lattice Model
folding
Peptides
26 Citations (Scopus)

Monte Carlo simulations of polymer brushes

Chen, C-M. & Fwu, Y. A., 2001 Dec 1, In : Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 63, 1 I, p. 115061-1150610 1035550 p., 011506.

Research output: Contribution to journalArticle

brushes
Polymers
Monte Carlo Simulation
polymers
simulation
2000
37 Citations (Scopus)

Dilution wave and negative-order crystallization kinetics of chain molecules

Ungar, G., Mandal, P. K., Higgs, P. G., De Silva, D. S. M., Boda, E. & Chen, C-M., 2000 Nov 13, In : Physical Review Letters. 85, 20, p. 4397-4400 4 p.

Research output: Contribution to journalArticle

Crystallization
dilution
crystallization
kinetics
Growth
13 Citations (Scopus)

Theory for the bending rigidity of protein-coated lipid membranes

Chen, C-M., 2000 Jun 15, In : Physica A: Statistical Mechanics and its Applications. 281, 1, p. 41-50 10 p.

Research output: Contribution to journalConference article

Lipids
rigidity
Rigidity
Membrane Protein
lipids
1999
35 Citations (Scopus)
Anisotropy
Membrane Lipids
Lipids
lipids
Membrane
1998
76 Citations (Scopus)

Monte-Carlo simulations of polymer crystallization in dilute solution

Chen, C-M. & Higgs, P. G., 1998 Mar 8, In : Journal of Chemical Physics. 108, 10, p. 4305-4314 10 p.

Research output: Contribution to journalArticle

Crystallization
Polymers
crystallization
Defects
Crystals
1997
38 Citations (Scopus)

Theory of fission for two-component lipid vesicles

Chen, C-M., Higgs, P. G. & Mac Kintosh, F. C., 1997 Jan 1, In : Physical Review Letters. 79, 8, p. 1579-1582 4 p.

Research output: Contribution to journalArticle

fission
lipids
Lipids
curvature
rigidity
1996
19 Citations (Scopus)

Theory of modulated phases in lipid bilayers and liquid crystal films

Chen, C-M. & MacKintosh, F. C., 1996 Jan 1, In : Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics. 53, 5, p. 4933-4943 11 p.

Research output: Contribution to journalArticle

Liquid Crystals
Lipid Bilayer
Phase Transition
Lipid Bilayers
Liquid Crystal
1995
62 Citations (Scopus)

Phase transitions and modulated phases in lipid bilayers

Chen, C-M., Lubensky, T. C. & MacKintosh, F. C., 1995 Jan 1, In : Physical Review E. 51, 1, p. 504-513 10 p.

Research output: Contribution to journalArticle

Lipid Bilayer
Phase Transition
Lipid Bilayers
lipids
Modulation
8 Citations (Scopus)

Structural phase transitions in liquid-crystal films induced by an applied electric field.

Chen, C. M. & Mackintosh, F. C., 1995 May 1, In : EPL. 30, 4, p. 215-220 6 p.

Research output: Contribution to journalArticle

liquid crystals
electric fields
symmetry
4 Citations (Scopus)

Swelling Kinetics of Layered Structures: Triblock Copolymer Mesogels

Chen, C-M., Mackintosh, F. C. & Williams, D. R. M., 1995 Jul 1, In : Langmuir. 11, 7, p. 2471-2475 5 p.

Research output: Contribution to journalArticle

swelling
Block copolymers
Swelling
Elasticity
copolymers
1994
2 Citations (Scopus)

Higgs boson production via the Bjorken process e+e-→H0μ+μ- at high energy e+e- colliders

Chen, C-M., Chen, J. W. & Hwang, W. Y. P., 1994 Jan 1, In : Physical Review D. 50, 7, p. 4485-4490 6 p.

Research output: Contribution to journalArticle

Higgs bosons
cross sections
center of mass
positrons
asymmetry
1993
11 Citations (Scopus)

Relativistic cross sections of positron-impact ionization of hydrogenic ions

Kuo, T. Y., Chen, C-M., Hsu, S. W. & Huang, K. N., 1993 Jan 1, In : Physical Review A. 48, 1, p. 357-363 7 p.

Research output: Contribution to journalArticle

positrons
ionization
cross sections
ions
relativistic effects
1992
15 Citations (Scopus)

Discrepancy in total cross sections of positron-impact ionization of hydrogen

Hsu, S. W., Kuo, T. Y., Chen, C-M. & Huang, K. N., 1992 Jul 20, In : Physics Letters A. 167, 3, p. 277-279 3 p.

Research output: Contribution to journalArticle

positrons
ionization
cross sections
hydrogen
hydrogen atoms