Oral administration of green tea Epigallocatechin-3-gallate reduces oxidative stress and enhances restoration of cardiac function in diabetic rats receiving autologous transplantation of adipose-derived stem cells

  • Hsin-Hung Lin (Contributor)
  • Shaw Yih Liou (Contributor)
  • Yueh-Min Lin (Contributor)
  • Chien Chung Lin (Contributor)
  • Chun-Hsu Yao (Contributor)
  • Kuan-Ho Lin (Contributor)
  • Wei-Wen Kuo (Contributor)
  • Tung Sheng Chen (Contributor)
  • Meng-Yu Hung (Contributor)
  • Chih-Yang Huang (Contributor)
  • V. Vijaya Padma (Contributor)

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Description

Cardio-dysfunction is one of the complications in patients with diabetes mellitus (DM). This paper aimed to investigate if oral administration of green tea Epigallocatechin-3-gallate (EGCG, E) and transplantation of adipose-derived stem cells (ADSC) show cross effects on the treatment of cardiomyopathy in rats with type 1 DM. Wistar male rats were divided into four groups (each group contained 8 animals) including sham, DM (diabetic group), DM + ADSC (DM group with ADSC treatment) and DM + ADSC + E (DM + ADSC group with oral administration of EGCG). Pathological parameters including hypertrophy, inflammation, and fibrosis were activated in DM group. By contrast, all parameters were significantly improved in treatment group (DM + ADSC group). In addition, improvement of pathological parameters in DM + ADSC + E was significantly better than DM + ADSC. We found that EGCG can increase expression of survival marker in ADSC under high glucose environment and reduce serum oxidative stress in DM rats.
Date made available2019 Jan 1
PublisherUnknown Publisher

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